Results 111 to 120 of about 1,862,769 (263)
Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application
Responsive Materials, EarlyView.Photo‐responsive CDs generate ROS to induce tumor cell pyroptosis, thereby stimulating antitumor immunity. Abstract Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in
Lingyun Li +5 more
wiley +1 more source
Small, EarlyView.Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley +1 more source
Rational engineering of microRNA-regulated viruses for cancer gene therapy [PDF]
, 2013 MicroRNAs (miRNAs) are small noncoding RNA molecules that have important regulatory roles in a wide range of biological processes. miRNAs are often expressed in a tissue- and/or differentiation state-specific patterns, and it is estimated that miRNAs can
Ylösmäki, Erkko
core
Recent Progress in Engineered Oncolytic Viruses [PDF]
This review examines recent research in engineered oncolytic viruses and applies a thematic analysis to identify trends in the field. The major themes identified are tumor microenvironment remodeling, enhancing virus efficiency, treating slow-growing ...
Manjila, Nihal
core +1 more source
Designing herpes viruses as oncolytics
Molecular Therapy - Oncolytics, 2015 Oncolytic herpes simplex virus (oHSV) was one of the first genetically-engineered oncolytic viruses. Because herpes simplex virus (HSV) is a natural human pathogen that can cause serious disease, it is incumbent that it be genetically-engineered or significantly attenuated for safety.
Peters, Cole, Rabkin, Samuel
openaire +5 more sources
Treatment of cancer with oncolytic viruses
International Journal of Research Publications, 2023 Abstract The battle against cancer continues to evolve, with oncolytic viruses emerging as a groundbreaking and promising avenue for innovative treatment. This paper provides a comprehensive overview of oncolytic viruses, a unique class engineered to selectively infect and destroy cancer cells, eliciting an immune response against tumors.
openaire +2 more sources
Oncolytic Viruses: Priming Time for Cancer Immunotherapy
BioDrugs, 2019 New immuno-oncology therapies are improving cancer treatments beyond the former standard of care, as evidenced by the recent and continuing clinical approvals for immunotherapies in a broad range of indications.
L. Russell, K. Peng, S. Russell, R. Diaz
semanticscholar +1 more source
Smart Molecules, EarlyView.The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou +4 more
wiley +1 more source
Oncolytic viruses in cancer immunotherapy [PDF]
, 2019 Oncolytic virotherapy is a field dedicated to exploiting viruses in the battle against cancer, where their specific cytolytic effects are sorely needed. This work focuses on the mechanisms and limitations of oncolytic virotherapy, on the recent advances ...
Zupko, Jakub
core
Oncolytic Herpes Simplex Viral Therapy: A Stride toward Selective Targeting of Cancer Cells
Frontiers in Pharmacology, 2017 Oncolytic viral therapy, which makes use of replication-competent lytic viruses, has emerged as a promising modality to treat malignancies. It has shown meaningful outcomes in both solid tumor and hematologic malignancies.
Dhaval S. Sanchala +2 more
doaj +1 more source