Results 111 to 120 of about 19,867 (255)
Updates on intratumoral therapies in melanoma
Cancer, Volume 132, Issue 13, 1 July 2026.Abstract Intratumoral therapies provide an opportunity for novel strategies in the management of advanced melanoma. These approaches deliver concentrated doses of therapeutic immune agents directly into individual tumor(s), achieving local tumor control and induction of systemic antitumor immune responses while minimizing the risk of immune‐related ...
Vincent T. Ma +12 more
wiley +1 more source
The multifunctional NS1 protein of influenza A viruses
, 2012 The non-structural (NS1) protein of influenza A viruses is a non-essential virulence factor that has multiple accessory functions during viral infection.
Hale, Benjamin Geoffrey +3 more
core +1 more source
Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives
MedComm, Volume 7, Issue 7, July 2026.Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen +6 more
wiley +1 more source
Arming vaccinia virus for pancreatic cancer oncolytic virotherapy
, 2011 PhDVaccinia virus is a 250-300nm enveloped DNA virus from the poxvirus family and is used as a vector for oncolytic viral gene therapy. No unique cell surface receptor has been identified for Vaccinia virus and the reasons for its tropism for cancer ...
Hiley, Crispin
core
Cells, 2018 Oncolytic virus therapy of cancer is an actively pursued field of research. Viruses that were once considered as pathogens threatening the wellbeing of humans and animals alike are with every passing decade more prominently regarded as vehicles for ...
Tereza Brachtlova +1 more
doaj +1 more source
Oncolytic Viruses: The Power of Directed Evolution
, 2012 Attempts at developing oncolytic viruses have been primarily based on rational design. However, this approach has been met with limited success. An alternative approach employs directed evolution as a means of producing highly selective and potent ...
Terry W. Hermiston, Maxine Bauzon
core +1 more source
The Present Status of Immuno-Oncolytic Viruses in the Treatment of Pancreatic Cancer
, 2020 Pancreatic ductal adenocarcinoma (PDAC) is the fifth leading cause of cancer-related death in Western countries. The incidence of PDAC has increased over the last 40 years and is projected to be the second leading cause of cancer death by 2030.
Scott D. Haller +2 more
core +1 more source
Pharmacological modulation of anti-tumor immunity induced by oncolytic viruses
Frontiers in Oncology, 2014 Oncolytic viruses kill cancer cells by direct lysis but also generate a significant anti-tumor immune response that allows for prolonged cancer control and in some cases cures.
Nicole E. Forbes +5 more
doaj +1 more source
Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.ABSTRACT The 2025 Cure Ocular Melanoma (CURE OM) Global Science Meeting took place in Amsterdam, The Netherlands on October 25th, 2025. Several promising drug candidates are in development; however, there is still an urgent need for better prevention, detection, and treatment of uveal melanoma.
Andrew E. Aplin +18 more
wiley +1 more source
International Journal of Cancer, Volume 158, Issue 12, Page 3252-3267, 15 June 2026.What's new? Oncolytic viruses are a promising immunotherapeutic approach against many malignancies. However, it is unclear whether repeated doses have improved therapeutic value or may trigger greater side effects, especially in patients with hepatocellular carcinoma whose liver is chronically damaged.
Karen J. Scott +10 more
wiley +1 more source