Results 131 to 140 of about 1,862,769 (263)
Cancer Innovation, Volume 5, Issue 4, August 2026.Innate immune cells (IICs) are not only as first‐line defenders or simple auxiliaries to adaptive immunity, but also as decisive regulators of non‐small cell lung cancer progression and treatment outcomes. ABSTRACT As a leading cause of cancer‐related morbidity and mortality worldwide, non‐small cell lung cancer (NSCLC) is profoundly influenced by ...
Jiaxin Liu +8 more
wiley +1 more source
Markedly enhanced intratumoral spread and antitumor effect of oncolytic adenovirus expressing decorin [PDF]
, 2008 With the aim of improving viral distribution and tumor penetration, we have engineered decorin expressing replication-incompetent (dl-LacZ-DCNG) and -competent (Ad-[DELTA]E1B-DCNG) adenoviruses.
Joo-Hang Kim +7 more
core +1 more source
Targeting tumor vasculature through oncolytic virotherapy: recent advances [PDF]
, 2015 The oncolytic virotherapy field has made significant advances in the last decade, with a rapidly increasing number of early- and late-stage clinical trials, some of them showing safety and promising therapeutic efficacy.
Merchan, Jaime R +1 more
core +1 more source
Immunity, 2019 SUMMARY Immunotherapy can reinvigorate dormant responses to cancer, but response rates remain low. Oncolytic viruses, which replicate in cancer cells, induce tumor lysis and immune priming, but their immune consequences are unclear.
Dayana B. Rivadeneira +11 more
semanticscholar +1 more source
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aims Neuroblastoma is the most common extracranial solid tumor and contributes the most to pediatric oncology deaths worldwide. Its clinical manifestations are heterogeneous, including relapses, and the prognosis remains poor, especially for high‐risk patients.
Mosammat Jannatul Mawa +3 more
wiley +1 more source
Cells, 2018 Oncolytic virus therapy of cancer is an actively pursued field of research. Viruses that were once considered as pathogens threatening the wellbeing of humans and animals alike are with every passing decade more prominently regarded as vehicles for ...
Tereza Brachtlova +1 more
doaj +1 more source
Oncolytic viruses: how “lytic” must they be for therapeutic efficacy?
Oncoimmunology, 2019 Oncolytic viruses (OVs) preferentially target and kill cancer cells without affecting healthy cells through a multi-modal mechanism of action. While historically the direct killing activity of OVs was considered the primary mode of action, initiation or ...
M. Davola, K. Mossman
semanticscholar +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.Acute myeloid leukemia (AML) is a disease characterized by uncontrolled proliferation and blocked maturation of hematopoietic stem and progenitor cells. Despite progress in its clinical management, many patients continue to relapse or show limited response to standard therapies, emphasizing the need for novel, safe, and more effective targeted ...
Rongrong Hu, Zaker Ataullev, Luping Lou
wiley +1 more source
Oncolytic viruses in cancer therapy
Cancer Letters, 2007 Oncolytic virotherapy is a promising form of gene therapy for cancer, employing nature's own agents to find and destroy malignant cells. The purpose of this review is to provide an introduction to this very topical field of research and to point out some of the current observations, insights and ideas circulating in the literature.
Vähä-Koskela, Markus J.V. +2 more
openaire +2 more sources
Design and application of oncolytic viruses for cancer immunotherapy.
Current Opinion in Biotechnology, 2019 The approval of the first oncolytic virus (OV) for the treatment of metastatic melanoma and the recent discovery that the use of oncolytic viruses may enhance cancer immunotherapies targeted against various immune checkpoint proteins have attracted great
E. Ylösmäki, V. Cerullo
semanticscholar +1 more source