Results 131 to 140 of about 26,553 (248)

‘BJUI Clinical Dilemma’: Recurrent high‐grade non‐muscle‐invasive bladder cancer in 2026

BJU International, EarlyView.
Vignesh T. Packiam, Peter C. Black, James W. F. Catto, Saum Ghodoussipour, Max Kates, Ashish M. Kamat, Yair Lotan, Michael A. O’Donnell, Jeremy Y. C. Teoh, George N. Thalmann, Stephen B. Williams   +10 more
wiley   +1 more source

Combining Small‐Molecular Compounds With CAR T‐Cell Therapy: Novel Strategies for Enhanced Cancer Immunotherapy

Cancer Innovation, Volume 5, Issue 2, April 2026.
Chimeric antigen receptor (CAR) T‐cell therapy, although revolutionary for haematological malignancies, faces significant challenges, including T‐cell exhaustion, limited persistence, and treatment‐related toxicity. The integration of small‐molecule compounds offers a promising strategy to overcome these limitations.
Rangzi Yi, Zijian Zhang, Yang Yang, Haichuan Zhu   +3 more
wiley   +1 more source

Global Advances in Hepatocellular Carcinoma Research and Therapy in 2025

Cancer Innovation, Volume 5, Issue 2, April 2026.
This review summarizes key breakthrough advances in hepatocellular carcinoma (HCC) reported in 2025 and presents a multidisciplinary management framework for HCC, integrating early diagnosis, microenvironment insights, and comprehensive therapeutic strategies spanning minimally invasive surgery, locoregional interventions, and systemic pharmacotherapy.
Bo Hu, Qiang Gao
wiley   +1 more source

Harnessing Tumor Organoids to Revolutionize Immunotherapy Research

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Immunotherapy has emerged as a revolutionary approach to cancer treatment, yet the lack of robust preclinical testing platforms impedes progress in this field. Tumor organoids, three‐dimensional structures derived from patient‐specific samples, differ from conventional models by faithfully recapitulating the histological, genetic, and ...
Zhen Wang, Peipei Yin, Shizhan Cui, Hui Liu, Dan Li, Yang Yu, Baoshan Cao, Xiaojuan Liu   +7 more
wiley   +1 more source

Biopharmaceuticals for Cancer Treatment: An Update

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Cancer is one of the most debilitating diseases, causing profound physical and psychological impacts on patients. The global number of cancer patients has been steadily rising over the last few decades. The development of effective cancer therapies remains the primary focus in life science research, requiring a precise understanding of ...
Anupom Deb Nath, Yousuf Alam, Afsana Mustak Mim, Maksuda Akter, Mohammad Abbas Gani, Khondaker Muhammad Khairul Alam, Md. Nur Alam   +6 more
wiley   +1 more source

Oncolytics, Cancer-Fighting Viruses from Past to Future: A Literature Review [PDF]

پیاورد سلامت
Background and Aim: Oncolytic viruses, as novel and advanced tools in the field of treating various types of cancer, have played a very important role in medical developments.
Seyedeh Nasim Mirbahari, Sina Salari, Shabnam Shahrokh, Mohammadreza Zali, Mehdi Totonchi   +4 more
doaj  

The Potency of Mesenchymal Stem Cells as Viral Oncolytic Carriers

Clinical and Research Journal in Internal Medicine
Oncolytic viruses (OVs) represent a category of viruses that selectively replicate within tumor cells, destroying cancer cells through a dual mechanism involving viral oncolysis and the stimulation of the host's anti-tumor immune response.
Muhammad Farid Rakhman
doaj   +1 more source

Effects of Tumor Microenvironment on Lung Cancer Stem Cells: Bidirectional Regulatory Mechanisms

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Lung cancer, with a high mortality rate, poses challenges in treatment due to its invasiveness and heterogeneity. Lung cancer stem cells (LCSCs) are considered key contributors to recurrence and metastasis because of their self‐renewal, pluripotency, and drug resistance.
Hongyi Lai, Ruihang Luo, Wei Zou, Xuyang Liu, Maosen Liu, Mingshan Liu, Jingtao Zhang   +6 more
wiley   +1 more source

Small Molecule‐Based Conditional Gene Regulation: Advances and Applications

Chemistry–Methods, Volume 6, Issue 4, April 2026.
The precise, temporal, and reversible control of gene expression using small molecule ligands is crucial for understanding complex cellular functions and is rapidly advancing the field of synthetic biology. Small molecule‐mediated conditional gene regulation has widespread applications, including bio‐manufacturing, cellular reprogramming, gene therapy,
Mohd Afaque Ansari, Riddhima Sharma, Priyanka Swami, Ambadas B. Rode   +3 more
wiley   +1 more source

A characterisation of the immune cells in immunocompetent and immunodeficient mice with orthotopic brain tumors

Clinical &Translational Immunology, Volume 15, Issue 4, 2026.
Immune cell changes in orthotopic xenograft and syngenic brain tumor preclinical models. Abstract Objectives Glioblastoma is characterised by poor survival with few treatment advances for over 20 years. Immunotherapies, which have transformed treatment of other cancers, have been difficult to apply to glioblastoma because of its highly immune ...
Bryan Gardam, Eunwoo Nam, Paris M Kollis, Jasmine Kilyen‐Coles, S Lenin, Briony L Gliddon, Melinda N Tea, Stuart M Pitson, Michael P Brown, Lisa M Ebert, Tessa Gargett   +10 more
wiley   +1 more source