Results 1 to 10 of about 11,703 (213)
Oncolytic virotherapy: basic principles, recent advances and future directions
Signal Transduction and Targeted Therapy, 2023 Oncolytic viruses (OVs) have attracted growing awareness in the twenty-first century, as they are generally considered to have direct oncolysis and cancer immune effects.
Danni Lin, Yinan Shen, T. Liang
semanticscholar +1 more source
Small Hero with Great Powers: Vaccinia Virus E3 Protein and Evasion of the Type I IFN Response
Biomedicines, 2022 Poxviridae have developed a plethora of strategies to evade innate and adaptive immunity. In this review, we focused on the vaccinia virus E3 protein, encoded by the E3L gene. E3 is present within the Chordopoxvirinae subfamily (with the exception of the
Mateusz Szczerba +5 more
doaj +1 more source
Oncolytic Measles Virus Encoding MicroRNA for Targeted RNA Interference
Viruses, 2023 Virotherapy is a promising, novel form of cancer immunotherapy currently being investigated in pre-clinical and clinical settings. While generally well-tolerated, the anti-tumor potency of oncolytic virus-based monotherapies needs to be improved further.
Sophie C. Anker +7 more
doaj +1 more source
Evaluation of a toxoid fusion protein vaccine produced in plants to protect poultry against necrotic enteritis [PDF]
PeerJ, 2019 Background Necrotic enteritis (NE) is caused by type A strains of the bacterium Clostridium perfringens. Total global economic losses to the poultry industry due to NE is estimated to be over two billion dollars annually.
Joseph G.L. Hunter +7 more
doaj +2 more sources
Vaccines, 2022 The Omicron SARS-CoV-2 variant has been designated as a variant of concern because its spike protein is heavily mutated. In particular, the Omicron spike is mutated at five positions (K417, N440, E484, Q493, and N501) that have been associated with ...
Karen V. Kibler +9 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2020 Multiple myeloma (MM) is a hematological malignancy of monoclonal plasma cells that remains incurable. Standard treatments for MM include myeloablative regimens and autologous cell transplantation for eligible patients.
Nancy.Y. Villa +13 more
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Molecular Therapy: Oncolytics, 2021 Solid cancers that metastasize to the lungs represent a major therapeutic challenge. Current treatment paradigms for lung metastases consist of radiation therapy, chemotherapies, and surgical resection, but there is no single treatment or combination ...
John D. Christie +14 more
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npj Biofilms and Microbiomes, 2021 While sequencing technologies have revolutionized our knowledge of microbial diversity, little is known about the dynamic emergent phenotypes that arise within the context of mixed-species populations, which are not fully predicted using sequencing ...
Jiseon Yang +6 more
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EMBO Molecular Medicine, 2023 SARS‐CoV‐2 acute respiratory distress syndrome (ARDS) induces uncontrolled lung inflammation and coagulopathy with high mortality. Anti‐viral drugs and monoclonal antibodies reduce early COVID‐19 severity, but treatments for late‐stage immuno‐thrombotic ...
Liqiang Zhang +31 more
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Case report: Immunovirotherapy as a novel add-on treatment in a patient with thoracic NUT carcinoma
Frontiers in Oncology, 2022 NUT carcinoma (NC) is a rare and extremely aggressive form of cancer, usually presenting with intrathoracic or neck manifestations in adolescents and young adults.
Linus D. Kloker +25 more
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