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Annals of Hepatology, 2008 Current oncolytic virotherapy strategies are based in the accumulated understanding of the common molecular mechanisms displayed during cell transformation and viral infection, like cell cycle and apoptosis deregulations.
Ortiz-López Rocio +1 more
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Oncolytic Virotherapy for Melanoma Brain Metastases, a Potential New Treatment Paradigm?
Brain Sciences, 2021 Introduction: Melanoma brain metastases remain a devastating disease process with poor prognosis. Recently, there has been a surge in studies demonstrating the efficacy of oncolytic virotherapy for brain tumor treatment.
Sauson Soldozy +12 more
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Advances in oncolytic virotherapy
Communications Medicine, 2022 Recent years have seen rapid advances in the preclinical development and clinical evaluation of oncolytic (cancer-lysing) virus-based therapies, and these are emerging as treatment modality for some cancers.
Stephen J. Russell +3 more
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Delivery and Biosafety of Oncolytic Virotherapy
Frontiers in Oncology, 2020 In recent years, oncolytic virotherapy has emerged as a promising anticancer therapy. Oncolytic viruses destroy cancer cells, without damaging normal tissues, through virus self-replication and antitumor immunity responses, showing great potential for ...
Bin Tang
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Oncolytic virotherapy and the current approaches in veterinary medicine
German Journal of Veterinary Research, 2022 Cancer has an increasing incidence worldwide in humans and animals. In addition to traditional treatments such as surgery, radiotherapy, and chemotherapy, there is a search for new treatment strategies for cancer treatment.
Bengu Bilgic, Banu Dokuzeylul, Mehmet Or
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Virotherapy in Head and Neck Cancer
Oral Oncology ReportsHead and neck cancer, comprising a diverse group of malignancies, presents significant challenges in terms of treatment efficacy and patient outcomes.
Zhan Wang
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Pharmaceutics, 2022 Oncolytic virotherapy is a type of nanomedicine with a dual antitumor mechanism. Viruses are engineered to selectively infect and lyse cancer cells directly, leading to the release of soluble antigens which induce systemic antitumor immunity ...
Andreas E Albers, Meiyu Fang, Xu Qian
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Combination of oncolytic viruses and immune checkpoint inhibitors for treatment of high-grade gliomas [PDF]
Frontiers in NeurologyHigh-grade gliomas (HGG) such as glioblastoma are the most aggressive primary malignancies of the central nervous system. The median overall survival of glioblastoma is <15 months despite treatment with surgery, radiotherapy, and chemotherapy ...
Zhihong Qian +4 more
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Nature Biotechnology, 2012 Oncolytic virotherapy is an emerging treatment modality that uses replication-competent viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a single-shot virotherapy cure, identification of drugs that accelerate intratumoral virus propagation, strategies to maximize the immunotherapeutic action of oncolytic viruses ...
Russell, Stephen J +2 more
openaire +3 more sources
Small Hero with Great Powers: Vaccinia Virus E3 Protein and Evasion of the Type I IFN Response
Biomedicines, 2022 Poxviridae have developed a plethora of strategies to evade innate and adaptive immunity. In this review, we focused on the vaccinia virus E3 protein, encoded by the E3L gene. E3 is present within the Chordopoxvirinae subfamily (with the exception of the
Mateusz Szczerba +5 more
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