Results 21 to 30 of about 11,703 (213)
Nano Letters, 2019 Currently, various oncolytic adenoviruses (OA) are being explored in both preclinical and clinical virotherapy. However, the pre-existing neutralizing antibodies (nAbs) and poor targeting delivery are major obstacles for systemically administered OA ...
Peng Lv, Xiaoyuan Chen, Chao Liu
exaly +2 more sources
The combination therapy of oncolytic virotherapy
Frontiers in PharmacologyIntroduction: Compared to other cancer immunotherapies, oncolytic viruses possess several advantages, including high killing efficiency, excellent targeting capabilities, minimal adverse reactions, and multiple pathways for tumor destruction.
Yue Wang +4 more
semanticscholar +4 more sources
Nature Biotechnology, 2012 Oncolytic virotherapy is an emerging treatment modality that uses replication-competent viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a single-shot virotherapy cure, identification of drugs that accelerate intratumoral virus propagation, strategies to maximize the immunotherapeutic action of oncolytic viruses ...
Russell, Stephen J +2 more
openaire +3 more sources
Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial
Nature Medicine, 2023 Immune-mediated anti-tumoral responses, elicited by oncolytic viruses and augmented with checkpoint inhibition, may be an effective treatment approach for glioblastoma. Here in this multicenter phase 1/2 study we evaluated the combination of intratumoral
F. Nassiri +38 more
semanticscholar +1 more source
Gamma-irradiated Newcastle disease virus: an alternative inactivated oncolytic virotherapy. [PDF]
Immunol Cell BiolTo overcome biological risks associated with using live NDV as an oncolytic therapy, we developed gamma‐NDV as a safer alternative. Using a murine model for skin cancer, we show that intratumor administration of gamma‐NDV outperformed live‐NDV in terms of reducing tumor growth and improving overall animal survival. Abstract Newcastle disease virus (NDV)
Kennedy EV +10 more
europepmc +2 more sources
mAbs, 2021 Cancer therapeutics approved for clinical application include oncolytic viruses and antibodies, which evolved by nature, but were improved by molecular engineering.
Roland E. Kontermann +2 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis virus (VSV), parvovirus, mammalian reovirus (MRV), human adenovirus ...
Yi-Ying Wu +4 more
semanticscholar +1 more source
Nature Communications, 2023 Oncolytic adenoviruses (Ads)-mediated anti-tumor activity is related to virus-promoted autophagy in tumor cells. Here the authors describe the design of a microbial nanocomposite based on Ads-encapsulated in bacterial outer membrane vesicles to promote ...
Weiyue Ban +10 more
semanticscholar +1 more source
Cytokines in oncolytic virotherapy
Cytokine & Growth Factor Reviews, 2020 Tumors represent a hostile environment for the effector cells of cancer immunosurveillance. Immunosuppressive receptors and soluble or membrane-bound ligands are abundantly exposed and released by malignant entities and their stromal accomplices. As a consequence, executioners of antitumor immunity inefficiently navigate across cancer tissues and fail ...
Pol, Jonathan +4 more
openaire +3 more sources
Viruses, 2023 Oncolytic virotherapy constitutes a promising treatment option for many solid cancers, including peritoneal carcinomatosis (PC), which still represents a terminal stage of many types of tumors.
Jana Koch +12 more
doaj +1 more source