Results 1 to 10 of about 9,420 (171)

Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry. [PDF]

Clin Cancer Res
Abstract Purpose: NUT carcinoma (NC) is an underdiagnosed, poorly differentiated squamous cell cancer with a median survival of 6.7 months. Defined by NUTM1 fusions, NC enhances oncogene transcription, including MYC.
Kim JJ, Walton SA, Mahadevan NR, Haradon J, Paoloni F, Paik PK, Chaft JE, Hsu R, Piha-Paul SA, Jänne PA, Barbie DA, Sholl LM, DuBois SG, Hanna GJ, Shapiro GI, French CA, Luo J.   +16 more
europepmc   +5 more sources

Case Report and Literature Review: Primary Pulmonary NUT-Midline Carcinoma

Frontiers in Oncology, 2021
Nuclear protein of the testis (NUT) carcinoma is a very rare and aggressive carcinoma characterized by chromosomal rearrangement. NUT-midline carcinoma (NMC) can occur anywhere in the body, but most of the tumors are found in the midline anatomic ...
Yunxiang Zhang, Kai Han, Xiaotong Dong, Qian Hou, Tianbao Li, Li Li, Gengyin Zhou, Xia Liu, Guifeng Zhao, Wei Li   +9 more
doaj   +3 more sources

Shared PRAME epitopes are T-cell targets in NUT carcinoma [PDF]

Journal for ImmunoTherapy of Cancer
Background NUT carcinoma is a rare but highly lethal solid tumor without an effective standard of care. NUT carcinoma is caused by bromodomain-containing NUTM1 fusion oncogenes, most commonly BRD4::NUTM1.
Alex Rubinsteyn, Christopher A French, Ian J Davis, Maria J Sambade, Benjamin G Vincent, Steven P Vensko, Rishi S Kotecha, Jared M Weiss, Brandon A Price, Jeffrey L Jensen, Sara K Peterson, Jessica R Alley, Shawn Yu, Tomoaki Kinjo, Sarah N Bennett, Mitra Shabrang, Johnathan D Debetta, Julie K Geyer, Kwangok P Nickel, Randall J Kimple, Laura E Herring, Jeremy R Wang, Brian Kuhlman   +22 more
doaj   +2 more sources

Primary Uterine NUT Carcinoma: A Case Report and Literature Review [PDF]

Clinics and Practice
Background: Nuclear protein in testis (NUT) carcinoma is a rare, aggressive, and poorly differentiated epithelial malignancy characterized by the rearrangement of NUTM1 (NUT midline carcinoma family member 1) on 15q14.
Tetsuro Shiraishi, Iori Kisu, Naomi Kaneko, Takaaki Fukuda, Jun Watanabe, Ryoma Hayashi, Akihisa Ueno, Katsura Emoto, Kanako Nakamura, Yuya Nogami, Kosuke Tsuji, Kenta Masuda, Wataru Yamagami   +12 more
doaj   +2 more sources

A tough NUT carcinoma to crack. [PDF]

Pathologica
We describe the case of a NUT carcinoma of the thorax in a 27-year-old male, non-smoker, presenting a voluminous neoformation in the hilum and the left side of the mediastinum infiltrating heart and great vessels. The biopsy revealed a poorly differentiated cancer with focal crush artifact consisting of undifferentiated small to medium-size cells, with
Celi A, Bruno R, Vignali P, Petrini I, Valetto A, Bertini V, Fanucchi O, Chella A, Alì G.   +8 more
europepmc   +5 more sources

Radiotherapy Response Patterns in Thoracic NUT Carcinoma: A Case Report [PDF]

Respirology Case Reports
NUT carcinoma is a rare and highly aggressive malignancy, particularly when arising in the thorax. Radiotherapy is commonly used for symptom palliation; however, radiotherapeutic response patterns in thoracic NUT carcinoma remain poorly characterised. We
Fumihiro Kashizaki, Nanami Tsuchiya, Shohei Watanabe, Hanming Lin, Ryusuke Orii, Kentaro Yumoto, Yoshiyuki Yasuura, Naomi Kawano, Hiroyuki Osawa, Harumi Koizumi, Kenichi Takahashi   +10 more
doaj   +2 more sources

NUT Carcinoma: Clinicopathologic Features, Molecular Genetics and Epigenetics

Frontiers in Oncology, 2022
Nuclear protein in testis (NUT) carcinoma is a rare, highly aggressive, poorly differentiated carcinoma occurring mostly in adolescents and young adults.
Vanessa Moreno, Karan Saluja, Sergio Pina-Oviedo   +2 more
doaj   +3 more sources

Sequential multimodal management for recurrent pulmonary NUT carcinoma: a case report [PDF]

Frontiers in Oncology
BackgroundPulmonary NUT carcinoma is an ultra-rare and highly aggressive malignancy associated with extremely poor survival, especially in thoracic primary tumors.
Jincheng Su, Jincheng Su, Zirong Mi, Zirong Mi, Haizhou Yue, Haizhou Yue, Dongliang Bian, Peng Zhang, Peng Zhang   +8 more
doaj   +2 more sources

A nationwide survey of awareness and understanding of NUT carcinoma among clinicians in China [PDF]

BMC Health Services Research
Background NUT carcinoma is a rare and highly aggressive malignancy defined by NUTM1 gene rearrangement and is frequently misdiagnosed because of non-specific clinicopathological features.
Zhuomiao Ye, Dan Yang, Weiying Liu, Xin Li, Minghui Zhang, Mingzhu Yin   +5 more
doaj   +2 more sources

The Importance of Diagnosing NUT Midline Carcinoma [PDF]

Head and Neck Pathology, 2013
NUT midline carcinoma (NMC) is an aggressive subset of squamous cell carcinoma, genetically defined by rearrangement of the NUT gene. The rearrangements most often take the form of BRD4-NUT fusions, and in a minority of cases, BRD3-NUT or NUT-variant fusions.
Christopher French, French Christopher A   +1 more
exaly   +3 more sources