Results 1 to 10 of about 9,390 (183)

Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry. [PDF]

Clin Cancer Res
Abstract Purpose: NUT carcinoma (NC) is an underdiagnosed, poorly differentiated squamous cell cancer with a median survival of 6.7 months. Defined by NUTM1 fusions, NC enhances oncogene transcription, including MYC.
Kim JJ, Walton SA, Mahadevan NR, Haradon J, Paoloni F, Paik PK, Chaft JE, Hsu R, Piha-Paul SA, Jänne PA, Barbie DA, Sholl LM, DuBois SG, Hanna GJ, Shapiro GI, French CA, Luo J.   +16 more
europepmc   +5 more sources

Case Report and Literature Review: Primary Pulmonary NUT-Midline Carcinoma

Frontiers in Oncology, 2021
Nuclear protein of the testis (NUT) carcinoma is a very rare and aggressive carcinoma characterized by chromosomal rearrangement. NUT-midline carcinoma (NMC) can occur anywhere in the body, but most of the tumors are found in the midline anatomic ...
Xiaotong Dong, Tianbao Li, Gengyin Zhou   +2 more
exaly   +3 more sources

Shared PRAME epitopes are T-cell targets in NUT carcinoma. [PDF]

J Immunother Cancer
Background NUT carcinoma is a rare but highly lethal solid tumor without an effective standard of care. NUT carcinoma is caused by bromodomain-containing NUTM1 fusion oncogenes, most commonly BRD4::NUTM1.
Jensen JL, Peterson SK, Sambade MJ, Alley JR, Yu S, Kinjo T, Bennett SN, Vensko SP, Shabrang M, Debetta JD, Geyer JK, Price BA, Nickel KP, Kimple RJ, Kotecha RS, Herring LE, Davis IJ, Wang JR, French CA, Kuhlman B, Weiss JM, Rubinsteyn A, Vincent BG.   +22 more
europepmc   +2 more sources

Primary Uterine NUT Carcinoma: A Case Report and Literature Review. [PDF]

Clin Pract
Background: Nuclear protein in testis (NUT) carcinoma is a rare, aggressive, and poorly differentiated epithelial malignancy characterized by the rearrangement of NUTM1 (NUT midline carcinoma family member 1) on 15q14.
Shiraishi T, Kisu I, Kaneko N, Fukuda T, Watanabe J, Hayashi R, Ueno A, Emoto K, Nakamura K, Nogami Y, Tsuji K, Masuda K, Yamagami W.   +12 more
europepmc   +2 more sources

A tough NUT carcinoma to crack. [PDF]

Pathologica
We describe the case of a NUT carcinoma of the thorax in a 27-year-old male, non-smoker, presenting a voluminous neoformation in the hilum and the left side of the mediastinum infiltrating heart and great vessels. The biopsy revealed a poorly differentiated cancer with focal crush artifact consisting of undifferentiated small to medium-size cells, with
Celi A, Bruno R, Vignali P, Petrini I, Valetto A, Bertini V, Fanucchi O, Chella A, Alì G.   +8 more
europepmc   +5 more sources

NUT Carcinoma: Clinicopathologic Features, Molecular Genetics and Epigenetics

Frontiers in Oncology, 2022
Nuclear protein in testis (NUT) carcinoma is a rare, highly aggressive, poorly differentiated carcinoma occurring mostly in adolescents and young adults.
Karan Saluja, Sérgio Piña-Oviedo, Saluja Karan   +2 more
exaly   +3 more sources

Sequential multimodal management for recurrent pulmonary NUT carcinoma: a case report. [PDF]

Front Oncol
BackgroundPulmonary NUT carcinoma is an ultra-rare and highly aggressive malignancy associated with extremely poor survival, especially in thoracic primary tumors.
Su J, Mi Z, Yue H, Bian D, Zhang P.
europepmc   +2 more sources

Radiotherapy Response Patterns in Thoracic NUT Carcinoma: A Case Report. [PDF]

Respirol Case Rep
NUT carcinoma is a rare and highly aggressive malignancy, particularly when arising in the thorax. Radiotherapy is commonly used for symptom palliation; however, radiotherapeutic response patterns in thoracic NUT carcinoma remain poorly characterised. We
Kashizaki F, Tsuchiya N, Watanabe S, Lin H, Orii R, Yumoto K, Yasuura Y, Kawano N, Osawa H, Koizumi H, Takahashi K.   +10 more
europepmc   +2 more sources

The Importance of Diagnosing NUT Midline Carcinoma [PDF]

Head and Neck Pathology, 2013
NUT midline carcinoma (NMC) is an aggressive subset of squamous cell carcinoma, genetically defined by rearrangement of the NUT gene. The rearrangements most often take the form of BRD4-NUT fusions, and in a minority of cases, BRD3-NUT or NUT-variant fusions.
Christopher A French, French Christopher A   +1 more
exaly   +3 more sources

A nationwide survey of awareness and understanding of NUT carcinoma among clinicians in China. [PDF]

BMC Health Serv Res
Background NUT carcinoma is a rare and highly aggressive malignancy defined by NUTM1 gene rearrangement and is frequently misdiagnosed because of non-specific clinicopathological features.
Ye Z, Yang D, Liu W, Li X, Zhang M, Yin M.   +5 more
europepmc   +2 more sources