Results 1 to 10 of about 9,223 (166)

Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry. [PDF]

Clin Cancer Res
Abstract Purpose: NUT carcinoma (NC) is an underdiagnosed, poorly differentiated squamous cell cancer with a median survival of 6.7 months. Defined by NUTM1 fusions, NC enhances oncogene transcription, including MYC.
Kim JJ, Walton SA, Mahadevan NR, Haradon J, Paoloni F, Paik PK, Chaft JE, Hsu R, Piha-Paul SA, Jänne PA, Barbie DA, Sholl LM, DuBois SG, Hanna GJ, Shapiro GI, French CA, Luo J.   +16 more
europepmc   +4 more sources

Shared PRAME epitopes are T-cell targets in NUT carcinoma [PDF]

Journal for ImmunoTherapy of Cancer
Background NUT carcinoma is a rare but highly lethal solid tumor without an effective standard of care. NUT carcinoma is caused by bromodomain-containing NUTM1 fusion oncogenes, most commonly BRD4::NUTM1.
Alex Rubinsteyn, Christopher A French, Ian J Davis, Maria J Sambade, Benjamin G Vincent, Steven P Vensko, Rishi S Kotecha, Jared M Weiss, Brandon A Price, Jeffrey L Jensen, Sara K Peterson, Jessica R Alley, Shawn Yu, Tomoaki Kinjo, Sarah N Bennett, Mitra Shabrang, Johnathan D Debetta, Julie K Geyer, Kwangok P Nickel, Randall J Kimple, Laura E Herring, Jeremy R Wang, Brian Kuhlman   +22 more
doaj   +2 more sources

Primary Uterine NUT Carcinoma: A Case Report and Literature Review [PDF]

Clinics and Practice
Background: Nuclear protein in testis (NUT) carcinoma is a rare, aggressive, and poorly differentiated epithelial malignancy characterized by the rearrangement of NUTM1 (NUT midline carcinoma family member 1) on 15q14.
Tetsuro Shiraishi, Iori Kisu, Naomi Kaneko, Takaaki Fukuda, Jun Watanabe, Ryoma Hayashi, Akihisa Ueno, Katsura Emoto, Kanako Nakamura, Yuya Nogami, Kosuke Tsuji, Kenta Masuda, Wataru Yamagami   +12 more
doaj   +2 more sources

Radiotherapy Response Patterns in Thoracic NUT Carcinoma: A Case Report [PDF]

Respirology Case Reports
NUT carcinoma is a rare and highly aggressive malignancy, particularly when arising in the thorax. Radiotherapy is commonly used for symptom palliation; however, radiotherapeutic response patterns in thoracic NUT carcinoma remain poorly characterised. We
Fumihiro Kashizaki, Nanami Tsuchiya, Shohei Watanabe, Hanming Lin, Ryusuke Orii, Kentaro Yumoto, Yoshiyuki Yasuura, Naomi Kawano, Hiroyuki Osawa, Harumi Koizumi, Kenichi Takahashi   +10 more
doaj   +2 more sources

Case report: Diagnosis of NUT carcinoma of hepatic origin by next-generation sequencing [PDF]

Frontiers in Oncology, 2023
NUT carcinoma is a rare subcategory of squamous cell carcinoma. The latter is primarily characterized by the fusion of the coding sequence NUTM1 on chromosome 15q14 with BRD4 or BRD3, both of which are acetyl-histone binding bromodomains.
Bach Ardalan, Jose Azqueta, Jia Luo, Christopher French   +3 more
doaj   +2 more sources

A nationwide survey of awareness and understanding of NUT carcinoma among clinicians in China [PDF]

BMC Health Services Research
Background NUT carcinoma is a rare and highly aggressive malignancy defined by NUTM1 gene rearrangement and is frequently misdiagnosed because of non-specific clinicopathological features.
Zhuomiao Ye, Dan Yang, Weiying Liu, Xin Li, Minghui Zhang, Mingzhu Yin   +5 more
doaj   +2 more sources

The BRD4-NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma. [PDF]

Cancer Res, 2023
Abstract NUT carcinoma (NC) is an aggressive squamous carcinoma defined by the BRD4–NUT fusion oncoprotein. Routinely effective systemic treatments are unavailable for most NC patients.
Durall RT, Huang J, Wojenski L, Huang Y, Gokhale PC, Leeper BA, Nash JO, Ballester PL, Davidson S, Shlien A, Sotirakis E, Bertaux F, Dubus V, Luo J, Wu CJ, Keskin DB, Eagen KP, Shapiro GI, French CA.   +18 more
europepmc   +4 more sources

NUT carcinoma of the upper respiratory tract: Two case reports and literature review [PDF]

Science Progress
NUT carcinoma is a rare and highly aggressive malignancy characterized by the rearrangement of the NUTM1 gene. It typically arises in midline structures, including the respiratory tract. Due to its rarity and poor prognosis, early diagnosis and effective
Ya Jiang, Xiaofeng Xie, Ziran Gao, Chaohui Zhang, Qiang Feng, Yuanyuan Wang, Wenmang Xu   +6 more
doaj   +2 more sources

NUT carcinoma of the head and neck: A case report and literature review [PDF]

Precision Radiation Oncology
Nuclear protein in testis (NUT) carcinoma is a rare and highly aggressive cancer, characterized by rearrangements involving the NUT gene located on chromosome 15q14.
Yue Zhao, Jun Zhang, Wenjun Liao, Jiayu Li, Shichuan Zhang   +4 more
doaj   +2 more sources

Metastatic NUT Carcinoma in a Child. [PDF]

Indian J Otolaryngol Head Neck Surg, 2023
Nuclear protein of the testis (NUT) carcinoma is a rare and aggressive malignancy associated with rearrangements of the NUT gene on chromosome 15q14 .This entity is often under diagnosed and there is limited literature regarding its biology and optimal management.
Fonseca D, Kodandapani S, Babu RV, Rao C, Rao S.   +4 more
europepmc   +3 more sources