Results 41 to 50 of about 9,223 (166)

NUT Midline Carcinoma: A Rare Malignancy [PDF]

Cancer Control, 2017
Nuclear protein of the testis (NUT) midline carcinoma can present in the head, neck, and mediastinum. In general, it presents in young adult men and has a poor prognosis. We report on a case of NUT midline carcinoma of the mediastinum in a man 27 years of age without any prior malignancy.
Sameer, Al Diffalha, Nidal, Al Aukla, Saleh, Hasan, Shohreh, Dickinson, Farah, Khalil   +4 more
openaire   +2 more sources

Supercharging BRD4 with NUT in carcinoma

Oncogene, 2021
NUT carcinoma (NC) is an extremely aggressive squamous cancer with no effective therapy. NC is driven, most commonly, by the BRD4-NUT fusion oncoprotein. BRD4-NUT combines the chromatin-binding bromo- and extraterminal domain-containing (BET) protein, BRD4, with an unstructured, poorly understood protein, NUT, which recruits and activates the histone ...
Kyle P. Eagen, Christopher A. French
openaire   +3 more sources

Challenges and Opportunities in NUT Carcinoma Research [PDF]

Genes, 2021
NUT carcinoma (NC) is a type of aggressive cancer driven by chromosome translocations. Fusion genes between a DNA-binding protein, such as bromodomain and extraterminal domain (BET) proteins, and the testis-specific protein NUTM1 generated by these translocations drive the formation of NC.
Bin Gu, Maxwell C. Hakun
openaire   +2 more sources

p63-negative thoracic NUT carcinoma - A potential diagnostic pitfall

Indian Journal of Pathology and Microbiology
NUT carcinoma is a rare, aggressive, undifferentiated carcinoma characterized by NUTM1 gene rearrangement. It was formerly termed NUT midline carcinoma due to its propensity to occur in midline anatomical structures.
K R Anila, S M Kaviya, T Priyakumari, K Jayasree   +3 more
doaj   +1 more source

NUT Midline Carcinoma Mimics Anaplastic Thyroid Carcinoma

American Journal of Clinical Pathology, 2021
Abstract Introduction/Objective NUT carcinoma (NC) is an extremely rare, aggressive subtype of squamous cell carcinoma defined by rearrangement of the NUTM1 (aka NUT) gene. NC most commonly arises within the thorax and head and neck and predominantly affects teens and young adults. For the first time,
Q Chang, J Li, S Tang
openaire   +1 more source

Radiologic Manifestations of Pulmonary Nuclear Protein in Testis Midline Carcinoma: A Case Report

Journal of the Korean Society of Radiology, 2023
Nuclear portein in testis (NUT) midline carcinoma is a very rare and low-differentiating malignant epithelial tumor that differentiates very aggressively and has poor prognosis. NUT midline carcinoma occurring in the lungs in particular can be confused
Jung A Kim, Mi-jin Kang, Jung Yeon Kim, Ji-Young Kim, Soung Hee Kim, Myeong Ja Jeong, Ji Hae Lee   +6 more
doaj   +1 more source

NUT Carcinoma of the Sublingual Gland [PDF]

Head and Neck Pathology, 2015
NUT carcinoma (NC) is a recently described, rare and extremely aggressive cancer primarily located to supradiaphragmatic structures and affecting young individuals. NC is characterized by translocations involving the NUT gene on 15q14 with the most common translocation partner gene being BRD4 on 19p13, resulting in the t(15;19)(q14;p13) karyotype.
S. Andreasen, C. A. French, M. Josiassen, C. H. Hahn, K. Kiss   +4 more
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

Areca nut is associated with younger age of diagnosis, poor chemoradiotherapy response, and shorter overall survival in esophageal squamous cell carcinoma. [PDF]

PLoS ONE, 2017
OBJECTIVE:Areca nut chewing is carcinogenic to humans. However, little is known about the impact of areca nut chewing on esophageal squamous cell carcinoma (ESCC). METHODS:We retrospectively reviewed 286 ESCC patients who received surgery or preoperative
Chang-Han Chen, Hung-I Lu, Yu-Ming Wang, Yen-Hao Chen, Chien-Ming Lo, Wan-Ting Huang, Shau-Hsuan Li   +6 more
doaj   +1 more source