Results 1 to 10 of about 458,699 (164)
ProtoPred: Advancing Oncological Research Through Identification of Proto-Oncogene Proteins
IEEE Access, 2021 Proto-oncogenes are the genes that have the potential to transform normal cells into cancer cells as a result of mutations. They usually contain encoding of proteins whose function is to inhibit cell differentiation, stimulate cell division, and prevent ...
Sharaf J Malebary, Yaser Daanial Khan
exaly +3 more sources
The bZIP Proteins of Oncogenic Viruses [PDF]
Viruses, 2020 Basic leucine zipper (bZIP) transcription factors (TFs) govern diverse cellular processes and cell fate decisions. The hallmark of the leucine zipper domain is the heptad repeat, with leucine residues at every seventh position in the domain. These leucine residues enable homo- and heterodimerization between ZIP domain α-helices, generating coiled-coil ...
Madeleine L. Stolz, Craig McCormick
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Aberrations of growth factors as biomarkers of cancer progression [PDF]
Archive of Oncology, 2005 Cell proliferation and growth are regulated by a complex network of growth factor and growth inhibitorinitiated signal transduction pathways. The disruption of these signaling pathways through genetic, epigenetic, or somatic alterations is a major area ...
Ivanović Vesna
doaj +1 more source
Oncogenic Signaling Adaptor Proteins [PDF]
Journal of Genetics and Genomics, 2015 Signal transduction pathways activated by receptor tyrosine kinases (RTK) play a critical role in many aspects of cell function. Adaptor proteins serve an important scaffolding function that facilitates key signaling transduction events downstream of RTKs.
Leo Y, Luo, William C, Hahn
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Identification of an oncogenic RAB protein [PDF]
Science, 2015 Cancer as a case of uncontrolled traffic Healthy cells are like skilled air traffic controllers. They continually move proteins to and from the cellular destinations where they are needed, usually without mishap, through an elaborate system of endomembranes.
Wheeler, D. B. +4 more
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Scientific Reports, 2021 USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the subgroup that has aberrant TAL1 oncogene ...
Timothy I. Shaw +23 more
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Noncoding RNA Ginir functions as an oncogene by associating with centrosomal proteins. [PDF]
PLoS Biology, 2018 Long noncoding RNAs constitute a major fraction of the eukaryotic transcriptome, and together with proteins, they intricately fine-tune various growth regulatory signals to control cellular homeostasis.
Suchismita Panda +11 more
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Mutation Profile of Well-Differentiated Thyroid Cancer in Asians [PDF]
Endocrinology and Metabolism, 2015 Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated with the mitogen-activated protein kinase ...
Young Shin Song +2 more
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Biomédica: revista del Instituto Nacional de Salud, 2016 Introducción. Uno de los factores de riesgo del carcinoma de células escamosas en la cavidad oral es la infección por el virus del papiloma humano (HPV), cuyas prevalencias dependen de la región geográfica. Objetivo.
Alveiro Erira +5 more
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Oncogenic Potential of the Dual-Function Protein MEX3A [PDF]
Biology, 2021 MEX3A belongs to the MEX3 (Muscle EXcess) protein family consisting of four members (MEX3A-D) in humans. Characteristic for MEX3 proteins is their domain structure with 2 HNRNPK homology (KH) domains mediating RNA binding and a C-terminal really interesting new gene (RING) domain that harbors E3 ligase function.
Marcell Lederer +6 more
openaire +4 more sources