Results 1 to 10 of about 41,733 (183)

B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse. [PDF]

PLoS ONE, 2010
The B-raf proto-oncogene exerts essential functions during development and adulthood. It is required for various processes, such as placental development, postnatal nervous system myelination and adult learning and memory.
Agathe Valluet, Isabelle Hmitou, Sabrina Davis, Sabine Druillennec, Magalie Larcher, Serge Laroche, Alain Eychène   +6 more
doaj   +2 more sources

Association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool: retrospective study

World Journal of Surgical Oncology, 2023
Background Microcalcifications are suggested to be an indicator of thyroid malignancy, especially for papillary thyroid carcinoma (PTC), nonetheless, the association between macrocalcification and PTC is underexplored. Furthermore, screening methods like
Mengyao Ye, Shan Wu, Qi Zhou, Fang Wang, Xiaojun Chen, Xiaohua Gong, Wenjun Wu   +6 more
doaj   +2 more sources

The benefit of co-targeting PARP-1 and c-Met on the efficacy of radiotherapy in wild type BRAF melanoma

Frontiers in Medicine, 2023
Melanoma is known to be a radioresistant cancer. Melanoma radioresistance can be due to several factors such as pigmentation, antioxidant defenses and high Deoxyribonucleic acid (DNA) repair efficacy.
Malak Sabbah, Ahmad Najem, Christophe Vanderkerkhove, Fabien Kert, Younes Jourani, Fabrice Journe, Ahmad Awada, Dirk Van Gestel, Ghanem E. Ghanem, Mohammad Krayem, Mohammad Krayem   +10 more
doaj   +2 more sources

Combinational Inhibition of the eIF4F Complex, AKT1, and EZH2 Enhances Anticancer Effects in BRAF^V600E Mutant A375 Melanoma Cells. [PDF]

Oncol Res
Objectives The eukaryotic initiation factor 4F (eIF4F) translation initiation complex inhibitors (eIF4Fi) were recently found to hyperactivate extracellular signal-regulated kinases 1/2 (ERK1/2) signals, which contribute to acquired resistance to BRAF (B-
Miao Y, Hao F, Ki SH.
europepmc   +2 more sources

Differential Expression of Apoptosis-Stimulating Proteins of p53 (ASPPs) Between Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma. [PDF]

Diagnostics (Basel)
Objectives: Langerhans cell sarcoma (LCS) is a very rare, highly malignant tumor that originates from Langerhans cells. The differential diagnosis of LCS and Langerhans cell histiocytosis (LCH) still faces limitations, and the molecular changes involved ...
Wang C, Fan N, Yun T, Li F, Meng N, Wang Y, An J, Lyu X.   +7 more
europepmc   +2 more sources

Evaluation of HSP-27, BAP1, BRAF V600E, CCR7, and PD-L1 expression in uveal melanoma on enucleated eyes and metastatic liver tumors

The International Journal of Biological Markers, 2022
Background The presence of metastatic disease is one of the most important factors limiting survival in patients with uveal melanoma. Studies on proteins associated with metastatic mechanisms are sparse in the literature. Methods Enucleation samples from
Abdullah Ağın, Hayyam Kiratli, Servet Guresci, Berrin Babaoglu, Jale Karakaya, Figen Soylemezoglu   +5 more
doaj   +2 more sources

Nanoparticle-Mediated Trapping of Wnt Family Member 5A in Tumor Microenvironments Enhances Immunotherapy for B-Raf Proto-Oncogene Mutant Melanoma

ACS Nano, 2018
Development of an effective treatment against advanced tumors remains a major challenge for cancer immunotherapy. Approximately 50% of human melanoma is driven by B-Raf proto-oncogene mutation (BRAF-mutant).
Huan Xu, Hongda Zhu, Lin Hou
exaly   +2 more sources

Evaluating the anti-gut dysbiotic potential of bioactive primary metabolites derivatives from Lactaplantibacillus plantarum 12–3. An integrated ADMET, network pharmacology, molecular docking and normal mode analysis approaches

Frontiers in Nutrition
IntroductionIntestinal dysbiosis is a disorder of the gut microbiome, characterized by a loss of equilibrium between the microorganisms found in the gastrointestinal tract and their hosts.
Tariq Aziz, Tariq Aziz, Tariq Aziz, Emmanuel Pascal Owona, Nadège Thérèse Amougou Okoa, Mengue Ngadena Yolande Sandrine, Inam Ur Rahman, Abid Sarwar, Liqing Zhao, Liqing Zhao, Zhennai Yang, Metab Alharbi, Abdullah F. Alasmari   +12 more
doaj   +2 more sources

BRAFV600E Mutation Enhances Estrogen-Induced Metastatic Potential of Thyroid Cancer by Regulating the Expression of Estrogen Receptors [PDF]

Endocrinology and Metabolism, 2022
Background Cross-talk between mitogen-activated protein kinase and estrogen has been reported; however, the role of BRAFV600E in the estrogen responsiveness of thyroid cancer is unknown.
Minjun Kim, Su-jin Kim, Seong Yun Ha, Zhen Xu, Youngjin Han, Hyeon-Gun Jee, Sun Wook Cho, Young Joo Park, Kyu Eun Lee   +8 more
doaj   +1 more source

Mouse Models as a Tool for Understanding Progression in Braf-Driven Thyroid Cancers [PDF]

Endocrinology and Metabolism, 2019
The development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have confirmed the previously reported high frequency of
Iñigo Landa, Jeffrey A. Knauf
doaj   +1 more source