Results 31 to 40 of about 50,409 (184)

BRAF inhibitor or BRAF/MEK inhibitor treatment for patients with metastatic BRAF V600E mutated differentiated thyroid cancer [PDF]

Archives of Endocrinology and Metabolism
Objective: The aim of this study is to demonstrate the real-life efficacy of BRAF and MEK inhibitors in patients with advanced thyroid cancer. Subjects and methods: This retrospective study evaluated the clinical efficacy of either a BRAF inhibitor ...
Inbar Finkel, Yasmin Korzets, Assaf Moore, Tara Coreanu, Aron Popovtzer, Hagit Shoffel-Havakuk, Gideon Bachar, Jobran Mansour, Chana Weiss, Eyal Robenshtok   +9 more
doaj   +1 more source

Evaluation of HSP-27, BAP1, BRAF V600E, CCR7, and PD-L1 expression in uveal melanoma on enucleated eyes and metastatic liver tumors

The International Journal of Biological Markers, 2022
Background The presence of metastatic disease is one of the most important factors limiting survival in patients with uveal melanoma. Studies on proteins associated with metastatic mechanisms are sparse in the literature. Methods Enucleation samples from
Abdullah Ağın, Hayyam Kiratli, Servet Guresci, Berrin Babaoglu, Jale Karakaya, Figen Soylemezoglu   +5 more
doaj   +1 more source

Utilizing Protein Structure to Identify Non-Random Somatic Mutations [PDF]

, 2013
Motivation: Human cancer is caused by the accumulation of somatic mutations in tumor suppressors and oncogenes within the genome. In the case of oncogenes, recent theory suggests that there are only a few key "driver" mutations responsible for ...
Cheng, Yuwei, Cheung, Kei-Hoi, Modis, Yorgo, Ryslik, Gregory, Zhao, Hongyu   +4 more
core   +2 more sources

Immune check point inhibitors in BRAF mutated metastatic colorectal cancer: A review

International Journal of Gastrointestinal Intervention
Metastatic colorectal cancers with BRAF mutation are a class of tumors that have a poor prognosis compared to wild type patients. Even if this group has found some hope in targeted therapy with multi-targeted blockade of the mitogen-activated protein ...
Alfredo Colombo, Stefano Cordio, Concetta Maria Porretto   +2 more
doaj   +1 more source

Successful treatment with cladribine of Erdheim-Chester disease with orbital and central nervous system involvement developing after treatment of langerhans cell histiocytosis [PDF]

Vojnosanitetski Pregled, 2016
Introduction. Erdheim-Chester disease (ECD) is a rare, systemic form of non-Langerhans cell histiocytosis of the juvenile xantho-granuloma family with characteristic bilateral symmetrical long bone osteosclerosis, associated with ...
Perić Predrag, Antić Branislav, Knežević-Ušaj Slavica, Radić-Tasić Olga, Radovinović-Tasić Sanja, Vasić-Vilić Jasenka, Sekulović Leposava, Tarabar Olivera, Tukić Ljiljana, Jovandić Stevo, Magić Zvonko   +10 more
doaj   +1 more source

Molecular and cellular pathogenesis of melanoma initiation and progression [PDF]

, 2013
Melanoma is a malignant tumour of melanocytes, which can spread to other organs of the body resulting in severe and/or lethal malignancies. Melanocytes are pigment producing cells found in deep layer of the epidermis and are originated from melanocytes ...
Regad, T
core   +1 more source

Phenotype expansion of variants affecting p38 MAPK signaling in hypospadias patients

Orphanet Journal of Rare Diseases, 2022
Background Hypospadias is a congenital anomaly of the male urogenital system. Genetics factors play an important role in its pathogenesis. To search for potential causal genes/variants for hypospadias, we performed exome sequencing in a pedigree with ...
Defu Lin, Huakang Du, Sen Zhao, Bowen Liu, Hongcheng Song, Guannan Wang, Weiping Zhang, Haiyan Liang, Pei Liu, Chao Liu, Wenwen Han, Zhenwu Li, Yang Yang, Shuofan Chen, Lina Zhao, Xiaoxin Li, Zhihong Wu, DISCO (Deciphering Disorders Involving Scoliosis & COmorbidities) study group, Ning Sun, Nan Wu   +19 more
doaj   +1 more source

Consequences of a high incidence of microsatellite instability and BRAF‐mutated tumors: A population‐based cohort of metastatic colorectal cancer patients

Cancer Medicine, 2019
Background Immunotherapy for patients with microsatellite‐instable (MSI‐H) tumors or BRAF‐inhibitors combination treatment for BRAF‐mutated (mutBRAF) tumors in metastatic colorectal cancer (mCRC) is promising, but the frequency of these molecular changes
Kristine Ø. Aasebø, Anca Dragomir, Magnus Sundström, Artur Mezheyeuski, Per‐Henrik Edqvist, Geir Egil Eide, Fredrik Ponten, Per Pfeiffer, Bengt Glimelius, Halfdan Sorbye   +9 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Papillary thyroid carcinoma with nodular fasciitis-like stroma: a rare variant

Autopsy and Case Reports, 2021
Papillary thyroid carcinoma with desmoid-type fibromatosis (PTC-DTF) or nodular fasciitis-like stroma (PTC-NFS) is a rare morphological variant of PTC with a favorable prognosis. There is a paucity of molecular data regarding this entity.
Mayur Parkhi, Debajyoti Chatterjee, Anand Bardia, Anwin Joseph Kanaval, Ashwani Sood, Uma Nahar Saikia, Naval Bansal   +6 more
doaj