Results 31 to 40 of about 41,733 (183)

BRAF inhibitor or BRAF/MEK inhibitor treatment for patients with metastatic BRAF V600E mutated differentiated thyroid cancer [PDF]

Archives of Endocrinology and Metabolism
Objective: The aim of this study is to demonstrate the real-life efficacy of BRAF and MEK inhibitors in patients with advanced thyroid cancer. Subjects and methods: This retrospective study evaluated the clinical efficacy of either a BRAF inhibitor ...
Inbar Finkel, Yasmin Korzets, Assaf Moore, Tara Coreanu, Aron Popovtzer, Hagit Shoffel-Havakuk, Gideon Bachar, Jobran Mansour, Chana Weiss, Eyal Robenshtok   +9 more
doaj   +1 more source

HSP90 Inhibition Enhances the Anti-Tumor Efficacy of Combination Chemo Immunotherapy Targeting DNA Repair Proteins

, 2017
Submit Manuscript | http://medcraveonline.com Abbreviations: ACT: Adoptive Cellular Therapy; ATM: Ataxia Telangiectasia Mutated Protein; ATR: ATM and Rad3-Related Protein; BRAF: B-Raf proto-oncogene; BRCA: Breast Cancer; CFDA-SE: Carboxy Fluorescein ...
Subhara Raveendran, Ronald J Fecek, Micah Brown, K. Fabian, Jennifer L. Taylor, C. Carey, W. Storkus   +6 more
semanticscholar   +1 more source

Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review

World Journal of Clinical Oncology, 2020
BACKGROUND Ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment strategies. Different signaling pathways that participate in the progression of these tumors have
R. Gónzalez-Gónzalez, Sandra López-Verdín, Jesús Lavalle-Carrasco, N. Molina-Frechero, M. Isiordia-Espinoza, Ramón G Carreón-Burciaga, R. Bologna-Molina   +6 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Phenotype expansion of variants affecting p38 MAPK signaling in hypospadias patients

Orphanet Journal of Rare Diseases, 2022
Background Hypospadias is a congenital anomaly of the male urogenital system. Genetics factors play an important role in its pathogenesis. To search for potential causal genes/variants for hypospadias, we performed exome sequencing in a pedigree with ...
Defu Lin, Huakang Du, Sen Zhao, Bowen Liu, Hongcheng Song, Guannan Wang, Weiping Zhang, Haiyan Liang, Pei Liu, Chao Liu, Wenwen Han, Zhenwu Li, Yang Yang, Shuofan Chen, Lina Zhao, Xiaoxin Li, Zhihong Wu, DISCO (Deciphering Disorders Involving Scoliosis & COmorbidities) study group, Ning Sun, Nan Wu   +19 more
doaj   +1 more source

G48A, a New KRAS Mutation Found in Lung Adenocarcinoma

Journal of Thoracic Oncology, 2016
&NA; A new somatic mutation in the coding region of Kirsten rat sarcoma viral oncogene homolog gene (KRAS), G48A, has been identified in a patient with non–small cell lung cancer (NSCLC).
M. Marabese, E. Caiola, M. Garassino, G. Rastelli, G. Settanni, S. Brugnara, M. Broggini, M. Ganzinelli   +7 more
semanticscholar   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Successful treatment with cladribine of Erdheim-Chester disease with orbital and central nervous system involvement developing after treatment of langerhans cell histiocytosis [PDF]

Vojnosanitetski Pregled, 2016
Introduction. Erdheim-Chester disease (ECD) is a rare, systemic form of non-Langerhans cell histiocytosis of the juvenile xantho-granuloma family with characteristic bilateral symmetrical long bone osteosclerosis, associated with ...
Perić Predrag, Antić Branislav, Knežević-Ušaj Slavica, Radić-Tasić Olga, Radovinović-Tasić Sanja, Vasić-Vilić Jasenka, Sekulović Leposava, Tarabar Olivera, Tukić Ljiljana, Jovandić Stevo, Magić Zvonko   +10 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Consistency analysis of BRAF V600E mutation detection between immunohistochemical staining and next-generation sequencing in ganglioglioma

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To compare the consistency between immunohistochemical (IHC) staining and next-generation sequencing (NGS) in detecting BRAF alterations in ganglioglioma, to provide a reference for clinical selection of diagnostic approaches.
LI Jing-jun, WANG Xiu, CUI Yun
doaj   +1 more source