Results 21 to 30 of about 50,409 (184)

Risk factors analysis for BRAF gene V600E mutation in patients with infiltrative follicular papillary thyroid carcinoma [PDF]

精准医学杂志
Objective To investigate the risk factors for BRAF gene V600E mutation in patients with infiltrative follicular papillary thyroid carcinoma (IF-PTC). Methods A total of 134 patients with IF-PTC who underwent surgical treatment in our hospital from August
LI Lei, ZHAN Jiezhi, LI Hui, WANG Ruiqing, ZHAO Cheng
doaj   +1 more source

Association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool: retrospective study

World Journal of Surgical Oncology, 2023
Background Microcalcifications are suggested to be an indicator of thyroid malignancy, especially for papillary thyroid carcinoma (PTC), nonetheless, the association between macrocalcification and PTC is underexplored. Furthermore, screening methods like
Mengyao Ye, Shan Wu, Qi Zhou, Fang Wang, Xiaojun Chen, Xiaohua Gong, Wenjun Wu   +6 more
doaj   +1 more source

A personalized molecular approach in multiple myeloma: the possible use of RAF/RAS/MEK/ERK and BCL-2 inhibitors

Exploration of Targeted Anti-tumor Therapy, 2022
Multiple myeloma (MM) is a blood cancer that derives from plasma cells (PCs), which will accumulate in the bone marrow (BM). Over time, several drugs have been developed to treat this disease that is still uncurable.
Vincenzo Raimondi, Nicolas Thomas Iannozzi, Jessica Burroughs-Garcìa, Denise Toscani, Paola Storti, Nicola Giuliani   +5 more
doaj   +1 more source

Mutations of the BRAF gene in human cancer [PDF]

, 2002
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis ...
Bignell, G.R., Bigner, D.D., Bottomley, W., Chenevix-Trench, G., Clegg, S., Cooper, C., Cossu, A., Cox, C., Darrow, T.L., Davies, H., Davis, N., Dicks, E., Edkins, S., Ewing, R., Flanagan, A., Floyd, Y., Futreal, P.A., Garnett, M.J., Gray, K., Gusterson, B.A., Hall, S., Hargrave, D., Hawes, R., Ho, J.W.C., Hooper, S., Hughes, J., Jayatilake, H., Kosmidou, V., Leung, S.Y., Maitland, N., Marais, R., Marshall, C.J., Menzies, A., Mould, C., Nicholson, A., Palmieri, G., Parker, A., Paterson, H., Pritchard-Jones, K., Riggins, G.J., Seigler, H.F., Shipley, J., Stephens, P., Stevens, C., Stratton, M.R., Teague, J., Watt, S., Weber, B.L., Wilson, R., Woffendin, H., Wooster, R., Yuen, S.T.   +51 more
core   +1 more source

Genetic pathways, prevention, and treatment of sporadic colorectal cancer [PDF]

, 2014
Epithelial cancer of the colon and rectum, also known as colorectal cancer (CRC), results from a progressive accumulation of genetic and epigenetic alterations that lead to uncontrolled growth of colonocytes, the cells lining the colon and rectum. CRC is
Imperiale, Thomas F., Loehrer, Patrick J., Lu, Tao, Mundade, Rasika, Prabhu, Lakshmi   +4 more
core   +4 more sources

BRAF V600E expression in histiocytic sarcoma associated with splenic marginal zone lymphoma: a case report

Journal of Medical Case Reports, 2017
Background Histiocytic sarcoma is a rare histiocytic neoplasm of unknown etiology that constitutes less than 1% of hematologic malignancies. A few cases of histiocytic sarcoma harboring the BRAF V600E mutation have been reported, but this finding has not
John L. Vaughn, C. Eric Freitag, Jessica A. Hemminger, Jeffrey A. Jones   +3 more
doaj   +1 more source

Molecular docking investigation of cytotoxic phenanthrene derivatives

Comptes Rendus. Chimie, 2020
Our previous experimental work indicated that the presence of ester functionality in phenanthrene derivatives D-1 and D-2 leads to potent cytotoxicity against the Caco-2 cell line. The present work is based on th-is experimental result.
Guédouar, Habiba, Zaki, Hanane, Bouachrine, Mohammed, Aloui, Faouzi   +3 more
doaj   +1 more source

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. [PDF]

, 2012
Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that the tumour micro-environment confers innate resistance to therapy. Here we
Barzily-Rokni, Michal, Chapman, Paul B, Cooper, Zachary A, Davis, Ashli, Du, Jinyan, Flaherty, Keith T, Frederick, Dennie T, Golub, Todd R, Gould, Joshua, Lo, Roger S, Mongare, Margaret M, Morikawa, Teppei, Ogino, Shuji, Qian, Zhi Rong, Ribas, Antoni, Shee, Kevin, Solit, David B, Straussman, Ravid, Wargo, Jennifer A   +18 more
core   +1 more source

The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the Apc Min/+mouse small intestine [PDF]

, 2008
BackgroundAlterations in gene splicing occur in human sporadic colorectal cancer (CRC) and may contribute to tumour progression. The K-ras proto-oncogene encodes two splice variants, K-ras 4A and 4B, and K-ras activating mutations which jointly affect ...
Charles E Patek, Feijun Luo, Lorraine Rose, Marion Walker, Mark J Arends, Martin L Hooper, Nicola J Lawrence, Owen J Sansom, Paul S Devenney, Rachel A Ridgway, Rachel L Berry   +10 more
core   +4 more sources

Reciprocal regulation of PKA and rac signaling [PDF]

, 2013
Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and GTPase entities.
A. Riml, Baillie, Bhola, Birukova, Cook, Cuevas, Daaka, Delcourt, Dewire, Dorsam, Dumaz, E. Stefan, Eblen, G. S. Baillie, Gerits, Gloerich, Hafner, Hoffmann, Howe, Jaffe, K. R. Liedl, Kinderman, King, Kraynov, Kumar, Ligr, Malbon, Manser, Molli, Nika, Pierce, R. G. Huber, Sahai, Sch  fer, Scott, Smith, Stefan, Stork, T. Valovka, Taylor, Thaker, V. A. Bachmann, Wang, Wennerberg, Wong, Zenke, Zhang, Zhao   +47 more
core   +1 more source