Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
Nature Communications, 2020 The oncogene MLL is frequently translocated in leukemia, resulting in oncogenic fusion proteins. Here, the authors report a temporally controlled mouse model of MLL-ENL driven leukemia AND identify therapeutic targets associated with early MLL-ENL driven
Silvia Basilico +13 more
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Targeting DUBs to degrade oncogenic proteins [PDF]
British Journal of Cancer, 2020 Targeted protein degradation has emerged as a strategy in cancer therapy. Yang et al. discovered that HBX19818, an inhibitor of the deubiquitinase (DUB) USP10, leads to the dual degradation of spleen tyrosine kinase (SYK) and FLT3, resulting in death of AML cells.
Cremer, Anjali, Stegmaier, Kimberly
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C-terminal binding proteins: Emerging roles in cell survival and tumorigenesis [PDF]
, 2006 Within a cell, the levels and activity of multiple pro- and anti-apoptotic molecules act in concert to regulate commitment to apoptosis. Whilst the balance between survival and death can be tipped by the effects of single molecules, cellular apoptosis ...
Blaydes, J.P. +3 more
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An in silico study of the differential effect of oxidation on two biologically relevant G-quadruplexes: Possible implications in oncogene expression [PDF]
, 2012 G-quadruplex structures, formed from guanine rich sequences, have previously been shown to be involved in various physiological processes including cancer-related gene expression.
William J D Stebbeds +14 more
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VAV Proteins as Double Agents in Cancer: Oncogenes with Tumor Suppressor Roles
Biology, 2021 Guanosine nucleotide exchange factors (GEFs) are responsible for catalyzing the transition of small GTPases from the inactive (GDP-bound) to the active (GTP-bound) states. RHO GEFs, including VAV proteins, play essential signaling roles in a wide variety
Myriam Cuadrado, Javier Robles-Valero
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Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen
Nature Communications, 2022 Cancers often harbor mutations in genes encoding important regulatory proteins, but therapeutic targeting of these molecules proves difficult due to their high structural similarity to their non-mutated counterpart. Here authors show the engineering of T
Andrew Poole +24 more
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Mouse Models as a Tool for Understanding Progression in Braf-Driven Thyroid Cancers [PDF]
Endocrinology and Metabolism, 2019 The development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have confirmed the previously reported high frequency of
Iñigo Landa, Jeffrey A. Knauf
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Polycomb proteins and breast cancer [PDF]
, 2013 In the Western world, breast cancer is the most frequent malignancy in women and still the leading cause of cancer related deaths, therefore, a better understanding of the disease is needed.
Fedele, Vita
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Id Proteins - Tumor Markers or Oncogenes? [PDF]
Cancer Biology & Therapy, 2002 The Id (Inhibitor of differentiation or Inhibitor of DNA-binding) proteins act as dominant negative inhibitors of differentiation-specific basic Helix-Loop-Helix (bHLH) transcription factors. Id proteins negatively regulate cellular differentiation and they induce proliferation by modulating different cell cycle regulators both by direct and indirect ...
Jens, Hasskarl, Karl, Münger
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Primary colonic liposarcomatosis: report of a case with review of literature
Autopsy and Case Reports, 2019 LiposarcomaThe colon is a rare site of occurrence of liposarcoma, as either the primary site or by secondary involvement from a retroperitoneal liposarcoma. Liposarcomatosis denotes simultaneous occurrence of multiple liposarcomas.
Mahesh Sultania +4 more
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