Results 11 to 20 of about 458,798 (262)
DISTRIBUTION OF P53 ONCOGENE PROTEINS IN ORAL MALIGNANT LESIONS [PDF]
Acta Medica Iranica, 1995 Immunohi5tochemical determination ofoncogene proteins in human tumors is becoming increasingly important/or obtaining a better understanding ofprocess of tumorigenesis.
Behjat K.H. Moghadam +2 more
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Targeting DUBs to degrade oncogenic proteins [PDF]
British Journal of Cancer, 2020 Targeted protein degradation has emerged as a strategy in cancer therapy. Yang et al. discovered that HBX19818, an inhibitor of the deubiquitinase (DUB) USP10, leads to the dual degradation of spleen tyrosine kinase (SYK) and FLT3, resulting in death of AML cells.
Cremer, Anjali, Stegmaier, Kimberly
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Molecular Cancer, 2019 Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg ...
Ju-Ha Kim +5 more
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PLoS Pathogens, 2021 Intracellular pathogens have evolved to utilize normal cellular processes to complete their replicative cycles. Pathogens that interface with proliferative cell signaling pathways risk infections that can lead to cancers, but the factors that influence ...
Adrian J Luna +14 more
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Review papers The role of KIT gene mutations in pathogenesis of pediatric mastocytosis
Przegląd Dermatologiczny, 2015 Mastocytosis is characterized by excessive proliferation and accumulation of mast cells in skin and/or other organs. Two forms of the disease, cutaneous and systemic mastocytosis, differ significantly in symptomatology and clinical course.
Joanna Dawicka +5 more
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Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
Nature Communications, 2020 The oncogene MLL is frequently translocated in leukemia, resulting in oncogenic fusion proteins. Here, the authors report a temporally controlled mouse model of MLL-ENL driven leukemia AND identify therapeutic targets associated with early MLL-ENL driven
Silvia Basilico +13 more
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Oncogenic Properties of the EBV ZEBRA Protein [PDF]
Cancers, 2020 Epstein Barr Virus (EBV) is one of the most common human herpesviruses. After primary infection, it can persist in the host throughout their lifetime in a latent form, from which it can reactivate following specific stimuli. EBV reactivation is triggered by transcriptional transactivator proteins ZEBRA (also known as Z, EB-1, Zta or BZLF1) and RTA ...
Diego Germini +6 more
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Id Proteins - Tumor Markers or Oncogenes? [PDF]
Cancer Biology & Therapy, 2002 The Id (Inhibitor of differentiation or Inhibitor of DNA-binding) proteins act as dominant negative inhibitors of differentiation-specific basic Helix-Loop-Helix (bHLH) transcription factors. Id proteins negatively regulate cellular differentiation and they induce proliferation by modulating different cell cycle regulators both by direct and indirect ...
Jens, Hasskarl, Karl, Münger
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VAV Proteins as Double Agents in Cancer: Oncogenes with Tumor Suppressor Roles
Biology, 2021 Guanosine nucleotide exchange factors (GEFs) are responsible for catalyzing the transition of small GTPases from the inactive (GDP-bound) to the active (GTP-bound) states. RHO GEFs, including VAV proteins, play essential signaling roles in a wide variety
Myriam Cuadrado, Javier Robles-Valero
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Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen
Nature Communications, 2022 Cancers often harbor mutations in genes encoding important regulatory proteins, but therapeutic targeting of these molecules proves difficult due to their high structural similarity to their non-mutated counterpart. Here authors show the engineering of T
Andrew Poole +24 more
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