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Metanephric Adenoma with cystic changes- An uncommon presentation of a rare tumor in a young adult
Autopsy and Case Reports, 2021 Metanephric adenoma (MA) is a rare benign neoplasm of the kidney that is usually asymptomatic and incidentally diagnosed. MA usually present as a solid mass; however, a cystic presentation has been reported.
Darilin Shangpliang +6 more
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hMENA11a contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells. [PDF]
, 2015 Human Mena (hMENA), an actin regulatory protein of the ENA/VASP family, cooperates with ErbB receptor family signaling in breast cancer. It is overexpressed in high-risk preneoplastic lesions and in primary breast tumors where it correlates with HER2 ...
Circo, R +11 more
core +2 more sources
Identification of an oncogenic RAB protein [PDF]
Science, 2015 Cancer as a case of uncontrolled traffic Healthy cells are like skilled air traffic controllers. They continually move proteins to and from the cellular destinations where they are needed, usually without mishap, through an elaborate system of endomembranes.
Wheeler, D. B. +4 more
openaire +3 more sources
Signalling cell cycle arrest and cell death through the MMR System [PDF]
, 2006 Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics.
Brown, R., O'Brien, V.
core +1 more source
TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair. [PDF]
, 2016 E-cadherin is a cell adhesion molecule best known for its function in suppressing tumor progression and metastasis. Here we show that E-cadherin promotes nucleotide excision repair through positively regulating the expression of xeroderma pigmentosum ...
Barcellos-Hoff, MH +3 more
core +1 more source
Tumor protein D52 (TPD52) and cancer—oncogene understudy or understudied oncogene?
Tumor Biology, 2014 The Tumor protein D52 (TPD52) gene was identified nearly 20 years ago through its overexpression in human cancer, and a substantial body of data now strongly supports TPD52 representing a gene amplification target at chromosome 8q21.13. This review updates progress toward understanding the significance of TPD52 overexpression and targeting, both in ...
Jennifer A, Byrne +3 more
openaire +2 more sources
Targeting GLI factors to inhibit the Hedgehog pathway [PDF]
, 2015 Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer therapy because its aberrant activation is implicated in several cancers. Major progress has been made in the development of SMOOTHENED (SMO) antagonists, although
Alfonsi, Romina +4 more
core +2 more sources
DiagnosticsMicrosatellite Instability (MSI-H) occurs in approximately 15% of non-metastatic colon cancers, influencing patient outcomes positively compared to microsatellite stable (MSS) cancers. This systematic review focuses on the prognostic significance of KRAS,
Elena Orlandi +7 more
doaj +1 more source
IMMUNOHISTOCHEMICAL DETERMINATION OF TUMOR-ASSOCIATED ANTIGENS IN AMELOBLASTOMA AND ODONTOGENIC CYSTS [PDF]
Acta Medica Iranica, 1997 Transforming growth factor atpha (TGF-a), parathyroid hormone-tike proteins (PTHLP) and oncogene p53 proteins have all been demonstrated in a variety of human tumors anil have been implicated as causes of tumor cell aggressiveness.
B.K.H. Moghadam +3 more
doaj +2 more sources
HORMONE REPLACEMENT THERAPY AND CANCER
Zdravniški Vestnik, 2003 Background. Sex steroids are not known to damage DNA directly. They can stimulate or inhibit cell proliferation, and thus can modulate tumor developmental progression.Results.
Marjetka Uršič Vrščaj
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