Results 61 to 70 of about 635,296 (203)

WNT signalling in prostate cancer [PDF]

, 2017
Genome sequencing and gene expression analyses of prostate tumours have highlighted the potential importance of genetic and epigenetic changes observed in WNT signalling pathway components in prostate tumours-particularly in the development of castration-
A Ghoshal, A Gurney, A Jimeno, A Klaus, A Mallinger, A Mikels, A Säfholm, A Säfholm, AB El-Khoueiry, AC Vidal, AD,MR Kohn, AH Nile, AL Giraudet, AS Khaja, AS Perry, ASS Khaja, B Bilir, B Chen, B Madan, B Madan, BJ Feldman, BT MacDonald, C Fukukawa, C Lin, C Liu, C Liu, C Logan, C Niehrs, CL Chen, CM Cruciat, CS Grasso, CY Janda, D Grandy, D Robinson, D Zheng, DS Yee, DT Miyamoto, E Lee, E Lee, E Sandsmark, EE Storm, F Janku, F Ma, FC Gonsalves, G Chen, G O'Hurley, G Schulte, G Wang, GT Lee, H Beltran, H Clevers, H Hanaki, H Kimura, H Kumon, H Kumon, H Peradziryi, H Yamamoto, H Zhu, H-X Hao, HW Park, HX Hao, I Bisson, J Chinison, J Green, J Hao, J Liu, J Veeck, J Weischenfeldt, J-H Geng, JC Brase, JC Francis, JN Anastas, JP Dijksterhuis, JR Packer, K Ahmed, K Shojima, KC Valkenburg, KD Proffitt, KE Livermore, KH Emami, L Azzolin, L Fang, L Wu, L Zheng, LE Pascal, M Bordonaro, M Cojoc, M de la Roche, M Kahn, M Mancini, M Mazon, M Volante, M Yang, MD Shultz, MT Veeman, N Borcherding, N Li, N Takebe, NK Thudi, NN Yokoyama, O Dakhova, P Bovolenta, P García-Tobilla, P Le, P Polakis, P Rajan, P Uysal-Onganer, P Uysal-Onganer, PA Watson, R Eferl, R Kolb, R Siegel, R van Amerongen, R van Amerongen, RE O'Cearbhaill, RM Kypta, Robert Kypta, S Gupta, S Josson, S Martinez, S Perner, S Piccolo, S Takahashi, S Terry, S Thiele, S Thiele, S Zhang, S-P Huang, SA Tomlins, SH Lee, SJ Cooper, SJ Hotte, SJ Jung, SP Acebron, SP Acebron, T Chandrasekar, T Haikarainen, T Karantanos, T Malinauskas, T Phesse, TD Rachner, TM Bauman, TS Gujral, V Teneggi, Virginia Murillo-Garzón, W Lu, W Lu, W Tian, W Wang, X Chen, X Jiang, X Li, X Varelas, Y Eun-Jin, Y Kawano, Y Komiya, Y Li, Y Sun, Y Sun, Y Xie, Y Yang, Y Zhou, Y Zong, Z Debebe, Z Steinhart, ZG Li, ZJ Debruine   +166 more
core   +2 more sources

Localization of tyrosine kinase-coding region in v-abl oncogene by the expression of v-abl-encoded proteins in bacteria [PDF]

, 1985
A series of plasmids containing different segments of the v-abl oncogene have been constructed to express different portions of the v- abl protein in bacteria.
Baltimore, David, Wang, Jean Y. J.
core  

Polycation-π Interactions Are a Driving Force for Molecular Recognition by an Intrinsically Disordered Oncoprotein Family [PDF]

, 2013
Molecular recognition by intrinsically disordered proteins (IDPs) commonly involves specific localized contacts and target-induced disorder to order transitions.
A Arvand, A Bertolotti, A Bhattacherjee, A Boro, A Zarrine-Afsar, AB Sigalov, AG Turjanski, AH Mao, AH Mao, AK Dunker, AS Mahadevi, AS Reddy, AS Reddy, AY Tan, BA Shoemaker, C Haynes, D Alex, D Vijay, ED Ross, F Jin, G Gill, GM Lee, Guanghong Wei, HJ Dyson, HS Ashbaugh, HS Chan, HS Chan, Hue Sun Chan, HV Erkizan, HV Erkizan, I Staneva, J Danielsson, J Kim, J Singh, J Wang, J Wang, JC Hansen, JC Ma, JF Rual, Jianhui Song, JMR Baker, JP Gallivan, JP Gallivan, JS Barber-Rotenberg, JS Rao, JW Caldwell, Kevin A. W. Lee, KP Ng, KP Ng, KP Ng, L Feng, LM Iakoucheva, LM Salonen, M Azuma, M Borg, M Fuxreiter, M Levitt, MA Pufall, MS Cortese, MS Marshall, P Nash, P Tompa, P Tompa, PB Crowley, Peter Tompa, PJ Grohar, Q Lu, R Bachmaier, R Janknecht, R Petermann, R Wu, S Abeln, Sheung Chun Ng, SK Burley, SM Butterfield, T Mittag, T Mittag, V Neduva, VJ Hilser, VN Uversky, W Wang, W Zhong, X Chu, X Chu, X Xiu, Y Huang, Y Huang, Y Huang, Z Zhang   +88 more
core   +3 more sources

Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression

Nature Communications, 2018
Eya proteins are characterised by phosphatase activity associated with both the evolutionary conserved region and the less conserved N-terminal domain (NTD).
Lingdi Zhang, Hengbo Zhou, Xueni Li, Rebecca L Vartuli, Michael Rowse, Yongna Xing, Pratyaydipta Rudra, Debashis Ghosh, Rui Zhao, Heide L Ford   +9 more
doaj   +1 more source

Utilizing Protein Structure to Identify Non-Random Somatic Mutations [PDF]

, 2013
Motivation: Human cancer is caused by the accumulation of somatic mutations in tumor suppressors and oncogenes within the genome. In the case of oncogenes, recent theory suggests that there are only a few key "driver" mutations responsible for ...
Cheng, Yuwei, Cheung, Kei-Hoi, Modis, Yorgo, Ryslik, Gregory, Zhao, Hongyu   +4 more
core   +2 more sources

Histological and immunohistochemical findings in recurrent nevi [PDF]

Anais Brasileiros de Dermatologia
Background Recurrent nevi (RN) arise from the incomplete removal of a benign melanocytic lesion. They may present with clinical and dermoscopic characteristics similar to melanomas and are a potential mimic of neoplasia.
Maisa Aparecida Matico Utsumi Okada, Renata Heck, Renato Marchiori Bakos   +2 more
doaj   +1 more source

The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress. [PDF]

, 2011
Excessive demands on the protein-folding capacity of the endoplasmic reticulum (ER) cause irremediable ER stress and contribute to cell loss in a number of cell degenerative diseases, including type 2 diabetes and neurodegeneration.
Austgen, Kathryn, Curran, Tom, Johnson, Emily T, Oakes, Scott A, Park, Tae-Ju   +4 more
core  

Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. [PDF]

, 2015
BackgroundKey effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).MethodsWe used NSCLC ...
Aljilani, Amir, Lewis, Michael, Lu, Jie, Mortazavi, Fariborz, Pezeshkpour, Gholamhossein, Phan, Ryan, Tamanoi, Fuyuhiko, Trinidad, Kenny   +7 more
core   +2 more sources

RNF4-Dependent Oncogene Activation by Protein Stabilization [PDF]

Cell Reports, 2016
Ubiquitylation regulates signaling pathways critical for cancer development and, in many cases, targets proteins for degradation. Here, we report that ubiquitylation by RNF4 stabilizes otherwise short-lived oncogenic transcription factors, including β-catenin, Myc, c-Jun, and the Notch intracellular-domain (N-ICD) protein.
Thomas, Jane J, Abed, Mona, Heuberger, Julian, Novak, Rostislav, Zohar, Yaniv, Beltran Lopez, Angela P, Trausch-Azar, Julie S, Ilagan, Ma. Xenia G., Benhamou, David, Dittmar, Gunnar, Kopan, Raphael, Birchmeier, Walter, Schwartz, Alan L, Orian, Amir   +13 more
openaire   +5 more sources

Localization of the Major NF-κB-activating Site and the Sole TRAF3 Binding Site of LMP-1 Defines Two Distinct Signaling Motifs [PDF]

, 1997
The TRAF3 molecule interacts with the cytoplasmic carboxyl terminus (COOH terminus) of the Epstein-Barr virus-encoded oncogene LMP-1. NF-κB activation is a downstream signaling event of tumor necrosis factor receptor-associated factor (TRAF) molecules in
Baltimore, David, Brodeur, Scott R., Cheng, Genhong, Thorley-Lawson, David A.   +3 more
core   +1 more source