Results 81 to 90 of about 635,296 (203)

Cellular redox imbalance and changes of protein S-glutathionylation patterns are associated with senescence induced by oncogenic H-ras.

PLoS ONE, 2012
H-Ras oncogene requires deregulation of additional oncogenes or inactivation of tumor suppressor proteins to increase cell proliferation rate and transform cells. In fact, the expression of the constitutively activated H-RasV12 induces cell growth arrest
Tatiana Armeni, Luisa Ercolani, Lorena Urbanelli, Alessandro Magini, Francesca Magherini, Armanda Pugnaloni, Francesco Piva, Alessandra Modesti, Carla Emiliani, Giovanni Principato   +9 more
doaj   +1 more source

Quercetin elevates p27Kip1 and arrests both primary and HPV16 E6/E7 transformed human keratinocytes in G1 [PDF]

, 2003
Our previous work with primary bovine fibroblasts demonstrated that quercetin, a potent mutagen found in high levels in bracken fern (Pteridium aquilinum), arrested cells in G1 and G2/M, in correlation with p53 activation.
Alan G. Casson, Alexander Brehm, CA Marliere, Corinne Galiana, D.Leanne Jones, Eyal Reinstein, Fabeha Fazal, Fiamma Mantovani, Fuju Chang, Ingeborg Zehbe, J Villalobos-Salazar, Karl Münger, Kazumi Togawa, Keith W. Vance, Kumarasen Cooper, Lalai Suzuk, M. Cairney, M.Saveria Campo, Maria E. Jackson, Maria Saveria Campo, Masayuki Matoba, ME Jackson, Miguel E. Alonso-Amelot, Miguel E. Alonso‐Amelot, Nadir Arber, Nisar P. Malek, R.G. Beniston, Richard Garry Beniston, Stephen P. DAVIES, Taichi Hara, William D. Pennie   +30 more
core   +1 more source

The Effects of a Submaximal Endurance Swimming Training Period and Cadmium Poisoning during Pregnancy on the Hepatocyte Growth Factor Response in Neonatal Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives: Exposure to cadmium in early pregnancy has long-term effects on the growth and function of the liver. One of the pathways that controls proliferation of the fetal liver involves hepatocyte growth factor (HGF).
Hossein Ali Asgharzade Oliaei, Shadmehr Mirdar Harijani, Narges Mousavi   +2 more
doaj  

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Advanced Science
Emerging evidence highlights the role of SCF E3 ligases, consisting of SKP1, cullin‐1, and F‐box proteins, in cancer biology by regulating the ubiquitination and degradation of key proteins.
Hongxu Nie, Hengjie Xu, Sheng Yang, Chuanxin Tian, Tuo Wang, Chi Jin, Zhihao Chen, Xiaowei Wang, Junwei Tang, Yifei Feng, Yueming Sun   +10 more
doaj   +1 more source

P-rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments [PDF]

, 2013
Expression of the Rac-guanine nucleotide exchange factor (RacGEF), P-Rex1 is a key determinant of progression to metastasis in a number of human cancers.
A Eriksson, A Eva, A Hall, A Malliri, AJ Ridley, AM Woodward, Andrew D. Campbell, Antonio Facchiano, Bradford W. Ozanne, CR Lindsay, CR Lindsay, D Hanahan, D Hanahan, F Michiels, FG Haj, FK Johansson, FK Johansson, FN van Leeuwen, G Bergers, H Gerhardt, HC Welch, Heidi C. Welch, J Qin, JC Montero, Jim C. Norman, JM Ebos, K Hill, K Uhlenbrock, KL Rossman, LA Scott, Lynn C. McGarry, M Paez-Ribes, MA Barber, MJ Hart, MS Sosa, OD Weiner, PT Hawkins, R Heuchel, RA Seifert, RF Hennigan, RJ Petrie, S Katzav, Samuel Lawn, U Rodeck, X Xian   +44 more
core   +3 more sources

EGF and TGF-β1 effects on thyroid function [PDF]

, 2011
Normal epithelial thyroid cells in culture are inhibited by TGF-β1. Instead, transformed thyroid cell lines are frequently resistant to its growth inhibitory effect. Loss of TGF-β responsiveness could be due to a reduced expression of TGF-β receptors, as
Gabriella Mincione, Maria Carmela Di Marcantonio, Chiara Tarantelli, D'INZEO, SONIA, NICOLUSSI, Arianna, NARDI, Francesco, Caterina Francesca Donini, COPPA, Anna   +7 more
core   +2 more sources

An introspective update on the influence of miRNAs in breast carcinoma and neuroblastoma chemoresistance [PDF]

, 2014
Chemoresistance to conventional cytotoxic drugsmay occur in any type of cancer and this can either be inherent or develop through time. Studies have linked this acquired resistance to the abnormal expression of microRNAs (miRNAs) that normally silence ...
Ayers, Duncan, Carta, Alessia, Chetcuti, Rachel   +2 more
core   +4 more sources

Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells. [PDF]

, 2012
MicroRNAs are often associated with the pathogenesis of many cancers, including head and neck squamous cell carcinoma (HNSCC). In particular, microRNA-21 (miR-21) appears to have a critical role in tumor cell survival, chemoresistance and HNSCC ...
Bourguignon, LYW, Earle, C, Krueger, K, Spevak, CC, Wong, G   +4 more
core  

Drug resistance missense mutations in cancer are subject to evolutionary constraints.

PLoS ONE, 2013
Several tumour types are sensitive to deactivation of just one or very few genes that are constantly active in the cancer cells, a phenomenon that is termed 'oncogene addiction'.
Ran Friedman
doaj   +1 more source

Heterobifunctional proteomimetic polymers for targeted degradation of MYC and KRAS

Nature Communications
Targeted protein degradation (TPD) has enabled modulation of previously undruggable proteins. However, existing small-molecule approaches require arduous optimization and are largely confined to targets bearing ligandable pockets.
Max M. Wang, Mihai I. Truica, Brayley S. Gattis, Julia Oktawiec, Vinay Sagar, Ananya A. Basu, Paul A. Bertin, Xiaoyu Zhang, Sarki A. Abdulkadir, Nathan C. Gianneschi   +9 more
doaj   +1 more source