Results 81 to 90 of about 2,060,933 (285)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization

Molecular Cancer
Abstract Background Aberrant RHOA activation drives tumor progression, yet regulatory mechanisms beyond genetic mutations remain poorly defined. Lactylation, a lactate-derived post-translational modification, links metabolic reprogramming to oncogenesis, but its functional mimicry of genetic ...
Ma, Chenglong, Liao, Ruocen, Chen, Xingyu, Cao, Qianhua, Deng, Xinyue, Dai, Zhijun, Dong, Chenfang   +6 more
openaire   +2 more sources

Identification of pancreatic cancer invasion-related proteins by proteomic analysis [PDF]

, 2009
Background – Markers of pancreatic cancer invasion were investigated in two clonal populations of the cell line, MiaPaCa-2, Clone #3 (high invasion) and Clone #8 (low invasion) using proteomic profiling of an in vitro model of pancreatic cancer ...
Naomi Walsh, Walsh Naomi, Martin Clynes, Meleady Paula, Henry Michael, Clynes, Martin, Kennedy Susan, Susan Kennedy, O'Donovan, Norma, Clynes Martin, Michael Henry, Walsh, Naomi, Dowling, Paul, Paula Meleady, O'Donovan Norma, Meleady, Paula, Norma O'Donovan, Kennedy, Susan, O\u27Donovan, Norma, Henry, Michael, Dowling Paul, Paul Dowling   +21 more
core   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

The Effects of a Submaximal Endurance Swimming Training Period and Cadmium Poisoning during Pregnancy on the Hepatocyte Growth Factor Response in Neonatal Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives: Exposure to cadmium in early pregnancy has long-term effects on the growth and function of the liver. One of the pathways that controls proliferation of the fetal liver involves hepatocyte growth factor (HGF).
Hossein Ali Asgharzade Oliaei, Shadmehr Mirdar Harijani, Narges Mousavi   +2 more
doaj  

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Advanced Science
Emerging evidence highlights the role of SCF E3 ligases, consisting of SKP1, cullin‐1, and F‐box proteins, in cancer biology by regulating the ubiquitination and degradation of key proteins.
Hongxu Nie, Hengjie Xu, Sheng Yang, Chuanxin Tian, Tuo Wang, Chi Jin, Zhihao Chen, Xiaowei Wang, Junwei Tang, Yifei Feng, Yueming Sun   +10 more
doaj   +1 more source

p53 gain-of-function mutations promote metastasis via ENTPD5 upregulation and enhanced N-glycoprotein folding

Molecular & Cellular Oncology, 2017
Mutations in cancer abolish normal tumor suppressive functions of tumor protein p53 (TP53, best known as p53) and convert it into an oncogene. We recently reported the identification of ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5) as a ...
Oleg Timofeev, Thorsten Stiewe
doaj   +1 more source

Cellular redox imbalance and changes of protein S-glutathionylation patterns are associated with senescence induced by oncogenic H-ras.

PLoS ONE, 2012
H-Ras oncogene requires deregulation of additional oncogenes or inactivation of tumor suppressor proteins to increase cell proliferation rate and transform cells. In fact, the expression of the constitutively activated H-RasV12 induces cell growth arrest
Tatiana Armeni, Luisa Ercolani, Lorena Urbanelli, Alessandro Magini, Francesca Magherini, Armanda Pugnaloni, Francesco Piva, Alessandra Modesti, Carla Emiliani, Giovanni Principato   +9 more
doaj   +1 more source

p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia [PDF]

, 2011
Background: The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome.
Mahajna, Jamal, Y. Najajreh, Ruthardt, Martin, M. Ruthardt, Ottmann, Oliver G., J. Mahajna, Mian, Afsar Ali, Mian, Afsar A., Metodieva, Anna, Najajreh, Yousef, A. Metodieva, A. A. Mian, O. G. Ottmann   +12 more
core   +1 more source