Results 91 to 100 of about 635,296 (203)

Immune check point inhibitors in BRAF mutated metastatic colorectal cancer: A review

International Journal of Gastrointestinal Intervention
Metastatic colorectal cancers with BRAF mutation are a class of tumors that have a poor prognosis compared to wild type patients. Even if this group has found some hope in targeted therapy with multi-targeted blockade of the mitogen-activated protein ...
Alfredo Colombo, Stefano Cordio, Concetta Maria Porretto   +2 more
doaj   +1 more source

Tumor Heterogeneity at Protein Level as an Independent Prognostic Factor in Endometrial Cancer

Translational Oncology, 2014
Intratumor heterogeneity implies heterogeneous protein function, facilitating tumor adaptation which results in therapeutic failure. We hypothesized that tumor heterogeneity at protein level may influence the course of the disease.
Anna Supernat, Sylwia Łapińska-Szumczyk, Hanna Majewska, Jacek Gulczyński, Wojciech Biernat, Dariusz Wydra, Anna J. Żaczek   +6 more
doaj   +1 more source

Oncogenes, Protein Tyrosine Kinases, and Signal Transduction

Journal of Biomedical Science, 1994
Many oncogenes encode protein tyrosine kinases (PTKs). Oncogenic mutations of these genes invariably result in constitutive activation of these PTKs. Autophosphorylation of the PTKs and tyrosine phosphorylation of their cellular substrates are essential events for transmission of the mitogenic signal into cells.
D., Liu, L.-H., Wang
openaire   +2 more sources

Effect and mechanism of Juluo decoction combined with Ruhe powder in treatment of rat model of hyperplasia of mammary glands [PDF]

精准医学杂志
Objective To investigate the effect and mechanism of Juluo Decoction combined with Ruhe Powder in the treatment of rat model of hyperplasia of mammary glands.
NIE Weihong, LIU Hongxi, SUN Guoxin, LIU Chengcong, ZOU Xiao
doaj   +1 more source

Oncogenic Viral Protein Interactions with p53 Family Proteins

Klinicka Onkologie, 2019
Cellular transformation induced by oncogenic viruses is a complex process including viral molecules, host cells and environmental factors. Viruses alone are unable to reproduce and thus they need a host to use their signalling, proteosynthetic and metabolic pathways. One target host molecule is the p53 tumour suppressor.
V, Brychtová, V, Hrabal, B, Vojtěšek
openaire   +2 more sources

Molecular Basis of Oncogenic PI3K Proteins

Cancers
The dysregulation of phosphatidylinositol 3-kinase (PI3K) signaling plays a pivotal role in driving neoplastic transformation by promoting uncontrolled cell survival and proliferation. This oncogenic activity is primarily caused by mutations that are frequently found in PI3K genes and constitutively activate the PI3K signaling pathway.
Zhi Sheng, Patrick Beck, Maegan Gabby, Semhar Habte-Mariam, Katherine Mitkos   +4 more
openaire   +3 more sources

Expression of p53, c-erbB-2 and Cathepsin D in Relation to Hormone Receptors in Primary Breast Cancer

Siriraj Medical Journal, 2020
The immunohistochemical expression of p53, c-erbB-2, and cathepsin D oncogene proteins was examined in 494 primary breast carcinomas. This study aimed to investigate an association of expression of these three proteins with other variables known to be ...
Supornpim Chearskul, Kris Bhothisuwan, Smarn Onreabroi, Malika Churintrapun, Namoiy Semprasert   +4 more
doaj  

Mitochondrial superoxide dismutase controls metabolic plasticity in pancreatic cancer

Cell Communication and Signaling
Background The role of reactive oxygen species (ROS) in cancer is debated. One main antioxidant enzyme is mitochondrial superoxide dismutase (SOD2) which has been shown to influence tumor initiation and metastatic progression in several cancer types ...
Sankaranarayanan Ramasubramanian, Rupert Öllinger, Carola Eberhagen, Hans Zischka, Roland M. Schmid, Henrik Einwächter   +5 more
doaj   +1 more source

Study of MDM2 Promoter Polymorphism(SNP309) in Breast Cancer Patients in an Iranian Population

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2011
Introduction: Immunological processes play an important role in recurrent spontaneous abortion(RSA). According to studies, T lymphocytes and natural killer cells(NK cells) are two effective cell groups in RSA.
M Hossein Pour Feizi, S Taghizadeh, N Poulad, P Azarfam, V Montazeri   +4 more
doaj  

Molecular targeting of HPV oncogenes and oncogenic protein

, 2010
Worldwide cervical cancer is the second most common cause of cancer related death in women. Over the last three decades high-risk HPV has been conclusively established as the major etiological factor in cervical cancer and the expression of its two oncogenes, E6 and E7, are critical to the neoplastic progression.
openaire   +1 more source