Results 1 to 10 of about 2,580 (202)

Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma [PDF]

Cell Reports, 2017
Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcinoma (
Johannes Brägelmann, Marcel A. Dammert, Felix Dietlein, Johannes M. Heuckmann, Axel Choidas, Stefanie Böhm, André Richters, Debjit Basu, Verena Tischler, Carina Lorenz, Peter Habenberger, Zhizhou Fang, Sandra Ortiz-Cuaran, Frauke Leenders, Jan Eickhoff, Uwe Koch, Matthäus Getlik, Martin Termathe, Muhammad Sallouh, Zoltán Greff, Zoltán Varga, Hyatt Balke-Want, Christopher A. French, Martin Peifer, H. Christian Reinhardt, László Örfi, György Kéri, Sascha Ansén, Lukas C. Heukamp, Reinhard Büttner, Daniel Rauh, Bert M. Klebl, Roman K. Thomas, Martin L. Sos   +33 more
doaj   +7 more sources

Clinicopathological and molecular characterizations of pulmonary NUT midline carcinoma [PDF]

Cancer Medicine, 2021
Introduction Pulmonary nuclear protein of the testis (NUT) midline carcinoma (NMC) is a aggressive cancer with t (15, 19) translocation. Here we present the clinicopathological characteristics and molecular genetics alterations of primary pulmonary NMC ...
Mian Xie, Xinge Fu, Wei Wang
doaj   +5 more sources

Alpha–fetoprotein elevation in NUT midline carcinoma: a case report [PDF]

BMC Cancer, 2017
Background Nuclear protein in testis (NUT) midline carcinoma is a rarely diagnosed and potentially under-recognized type of squamous carcinoma that is considered one of the most aggressive human solid tumors.
Lorenzo D’Ambrosio, Erica Palesandro, Marina Moretti, Giuseppe Pelosi, Alessandra Fabbri, Fabrizio Carnevale Schianca, Massimo Aglietta, Giovanni Grignani   +7 more
doaj   +5 more sources

Case Report and Literature Review: Primary Pulmonary NUT-Midline Carcinoma [PDF]

Frontiers in Oncology, 2021
Nuclear protein of the testis (NUT) carcinoma is a very rare and aggressive carcinoma characterized by chromosomal rearrangement. NUT-midline carcinoma (NMC) can occur anywhere in the body, but most of the tumors are found in the midline anatomic ...
Yunxiang Zhang, Kai Han, Xiaotong Dong, Qian Hou, Tianbao Li, Li Li, Gengyin Zhou, Xia Liu, Guifeng Zhao, Wei Li   +9 more
doaj   +2 more sources

NUT midline carcinoma in a young pregnant female: a case report [PDF]

World Journal of Surgical Oncology, 2020
Introduction The NUT midline carcinoma is a rare tumor mostly reported in the midline of upper aerodigestive tract and mediastinum. Children as well as adolescents are affected without a gender distribution. A standard treatment is not established.
Sebastian Joel, Friederike Weschenfelder, Ekkehard Schleussner, Gunther O. Hofmann, Wolfram Weschenfelder   +4 more
doaj   +2 more sources

NUT Midline Carcinoma Masquerading As a Thymic Carcinoma [PDF]

Journal of Clinical Oncology, 2016
Thymic carcinomas are rare tumors that arise from the epithelium of the thymus gland and characterized by cytologic atypia, invasiveness, and high risk of relapse and death.1–3 The current WHO schema recognizes at least 11 histologic subtypes.4–7 ...
Badve, Sunil, Gökmen-Polar, Yesim, Kesler, Kenneth, Loehrer, Patrick J., Sr.   +3 more
core   +3 more sources

A rare case of P63-negative sinonasal NUT midline carcinoma in the elderly [PDF]

European Journal of Case Reports in Internal Medicine
A nuclear protein in testis (NUT) midline carcinoma arises from squamous cells and is often located in the head, neck, and lungs. This report focuses on the negative p63 mutation and older age at the diagnosis of a NUT carcinoma, which has significant ...
Anum Qayum, Malik Waleed Zeb Khan, Abdul Rehman Arshad, Samar Hasnain, Muhammad Danyal Tariq, Salman Khan, Shakir Ullah   +6 more
doaj   +2 more sources

NUT midline carcinoma. [PDF]

Cancer Genet Cytogenet, 2010
NUT midline carcinoma (NMC) is a rare, aggressive human cancer, genetically defined by rearrangements of the gene NUT (HUGO symbol: C15orf55). In the majority (∼75%) of NMCs, most of the coding sequence of NUT on chromosome 15q14 is fused with BRD4 creating chimeric genes that encode BRD-NUT fusion proteins. In the remaining cases, NUT is fused to BRD3
French CA.
europepmc   +11 more sources

Clinical features, treatment, and survival outcome of primary pulmonary NUT midline carcinoma [PDF]

Orphanet Journal of Rare Diseases, 2020
Objective NUT midline carcinoma (NMC), a rare type of squamous cell carcinoma, is genetically characterised by NUT midline carcinoma family member 1 (NUTM1) gene rearrangement.
Xiao-Hong Xie, Li-Qiang Wang, Yin-Yin Qin, Xin-Qing Lin, Zhan-Hong Xie, Ming Liu, Jie-Xia Zhang, Ming Ouyang, Jun Liu, Ying-Ying Gu, Shi-Yue Li, Cheng-Zhi Zhou   +11 more
doaj   +2 more sources

NUT Midline Carcinoma of the Nasal Cavity. [PDF]

Head Neck Pathol, 2017
Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare, aggressive, poorly differentiated form of squamous cell carcinoma caused by a chromosomal rearrangement of the NUT gene on chromosome 15. These tumors have a predilection for midline and paramidline structures of the upper aerodigestive tract and mediastinum and can affect patients ...
Edgar M, Caruso AM, Kim E, Foss RD.
europepmc   +4 more sources