Results 41 to 50 of about 2,580 (202)

Some considerations on the WHO Histological classification of laryngeal neoplasms [PDF]

, 2019
A new edition of the World Health Organization (WHO) Histological classification of tumours of the hypopharynx, larynx, trachea and parapharyngeal space was published in 2017.
Devaney, Kenneth O., Ferlito, Alfio, Hellquist, Henrik, Hunt, Jennifer L.   +3 more
core   +2 more sources

Challenging Diagnosis in NUT Carcinoma [PDF]

, 2021
Nuclear protein in testis (NUT) carcinoma represents a highly aggressive, poorly differentiated carcinoma that is genetically defined by rearrangement of NUT gene.
Grosse, Alexandra, Grosse, Claudia
core   +1 more source

The rare cancer network: ongoing studies and future strategy. [PDF]

, 2014
The Rare Cancer Network (RCN) was formed in the early 1990's to create a global network that could pool knowledge and resources in the studies of rare malignancies whose infrequency prevented both their study with prospective clinical trials.
Atalar, B., Chang, K., Funk, R., Hallemeier, C., Houtte, P.V., Krengli, M., Krishnan, S., Lassen-Ramshad, Y., Miller, R.C., Mirimanoff, R.O., Ozsahin, M., Rooney, J., Sun, X.S., Thariat, J., Ugurluer, G., Zhang, L.J.   +15 more
core   +2 more sources

NUT Midline Carcinoma: An Aggressive Intrathoracic Neoplasm [PDF]

Journal of Thoracic Oncology, 2013
Nuclear protein in testis (NUT) midline carcinoma (NMC) is a poorly differentiated squamous cell carcinoma that is characterized by a balanced translocation between chromosomes 15 and 19 [t(15;19)(q14;p13.1)]. This genetic aberration results in the fusion of the NUT gene on chromosome 15 to the bromodomain containing 4 (BRD4) gene on chromosome 19. The
Parikh, Sameer A., French, Christopher A., Costello, Brian A., Marks, Randolph S., Dronca, Roxana S., Nerby, Craig L., Roden, Anja C., Peddareddigari, Vijay G., Hilton, John, Shapiro, Geoffrey I., Molina, Julian R.   +10 more
openaire   +2 more sources

Clinical guideline SEOM: cancer of unknown primary site [PDF]

, 2014
Cancer of unknown primary site is a histologically confirmed cancer which is manifested in advanced stage, with no identifiable primary site after the use of standard diagnostic procedures.
A. García Palomo, F. J. Barón Duarte, L. de la Cruz Merino, P. Borrega García, R. Collado Martín   +4 more
core   +1 more source

Genomic profiling of solid tumors harboring BRD4-NUT and response to immune checkpoint inhibitors

Translational Oncology, 2021
Background: The translocation t(15:19) produces the oncogenic BRD4-NUT fusion which is pathognomonic for NUT carcinoma (NC), which is a rare, but extremely aggressive solid tumor.
Jonathan W. Riess, Shaila Rahman, Waleed Kian, Claire Edgerly, Andreas M. Heilmann, Russell Madison, Shakti H. Ramkissoon, Shai Shlomi Klaitman, Jon H. Chung, Sally E. Trabucco, Dexter X. Jin, Brian M. Alexander, Samuel J. Klempner, Lee A. Albacker, Garrett M. Frampton, Laila C. Roisman, Vincent A. Miller, Jeffrey S. Ross, Alexa B. Schrock, Jeffrey P. Gregg, Nir Peled, Ethan S. Sokol, Siraj M. Ali   +22 more
doaj   +1 more source

Effect of bet missense mutations on bromodomain function, inhibitor binding and stability [PDF]

, 2016
Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a ...
Alessandra, Pasquo, Chiaraluce, Roberta, Consalvi, Valerio, Cynthia, Tallant, Lori, Clorinda, Lori, Laura, Petrosino, Maria, Stefan, Knapp   +7 more
core   +2 more sources

DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia. [PDF]

, 2015
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.We present a method that utilizes DNA methylation
Abrahamsson, Jonas, Barbany, Gisela, Bäcklin, Christofer L, Cavelier, Lucia, Dahlberg, Johan, Flaegstad, Trond, Forestier, Erik, Gustafsson, Mats G, Heyman, Mats M, Jónsson, Ólafur G, Kanerva, Jukka, Larsson, Rolf, Lönnerholm, Gudmar, Nordgren, Ann, Nordlund, Jessica, Palle, Josefine, Schmiegelow, Kjeld, Syvänen, Ann-Christine, Zachariadis, Vasilios, Öfverholm, Ingegerd, Övernäs, Elin   +20 more
core   +4 more sources

Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer [PDF]

, 2013
PurposeAmplification of MYC is one of the most common genetic alterations in lung cancer, contributing to a myriad of phenotypes associated with growth, invasion and drug resistance.
Akbay, Esra, Bradner, James E., Carretero, Julian, Chen, Zhao, Cheng, Katherine A., Cohoon, Travis J., Gao, Yandi, Kikuchi, Eiki, Kimmelman, Alec C., Kung, Andrew L., Qi, Jun, Shimamura, Takeshi, Soucheray, Margaret, Tchaicha, Jeremy H., Wong, Kwok-Kin   +14 more
core   +1 more source

NUT Carcinoma of the Submandibular Gland: A Case at This Uncommon Site with Review of the Literature [PDF]

, 2021
Nuclear protein in testis (NUT) carcinoma is a rare, highly aggressive, undifferentiated carcinoma that harbors a characteristic rearrangement of the NUTM1 gene. The majority arise in adolescents and young adults especially from the midline structures of
Blanco, Angel I, Duncan, Darryl, French, Christopher A, Guo, Tianhua, Jafri, Syed H, Karni, Ron J, Moreno, Vanessa, Saluja, Karan, Zhang, Songling, Zhu, Hui   +9 more
core   +3 more sources