Results 51 to 60 of about 2,580 (202)

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching [PDF]

, 2014
BACKGROUND: Acetylation of lysine residues in histone tails plays an important role in the regulation of gene transcription. Bromdomains are the readers of acetylated histone marks, and, consequently, bromodomain-containing proteins have a variety of ...
Anne-Claude Gingras, Catherine M Rogers, Chris Wells, Claire Strain-Damerell, Clarence Yapp, Jean-Philippe Lambert, Martin Philpott, Nicola A Burgess-Brown, Stefan Knapp, Susanne Müller   +9 more
core   +2 more sources

A rare case of NUT midline carcinoma

Gynecologic Oncology Case Reports, 2013
► NUT midline carcinoma is a rare and aggressive cancer arising in midline structures and is of squamous cell lineage. ► Diagnosis by use of molecular tests is possible with clinical suspicion. ► NUT midline carcinoma is refractory to conventional treatments, but understanding of molecular alterations may lead to an effective therapy.
Ball, Allison, Bromley, Amy, Glaze, Sarah, French, Christopher A., Ghatage, Prafull, Köbel, Martin   +5 more
openaire   +2 more sources

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains [PDF]

, 2018
Bromodomains have been pursued intensively over the past several years as emerging targets for the development of anticancer and anti-inflammatory agents.
Alessi, Dario R., Becht, Kelly, Blacklow, Stephen C., Bradner, James E., Buckley, Dennis L., Dai, Lingling, Deng, Xianming, DiBona, Amy, Diéguez-Martínez, Nora, Erazo, Tatiana, Fedorov, Oleg, Ferguson, Fleur M., Gomez, Nestor, Gray, Nathanael S., Hao, Mingfeng, Kim, Nam Doo, Lizcano, Jose M., Massefski, Walter, McKeown, Michael R., Muñoz-Guardiola, Pau, Offei-Addo, Nana Kwaku, Park, Paul M., Qi, Jun, Roberts, Justin M., Sim, Taebo, Wang, Jinhua, Xu, Xiang, Zhang, Jinwei   +27 more
core   +3 more sources

A 47-year-old woman with nuclear protein in testis midline carcinoma masquerading as a sinus infection: a case report and review of the literature

Journal of Medical Case Reports, 2019
Background Nuclear protein in testis midline carcinoma is a rare, highly metastatic undifferentiated carcinoma that typically arises in midline structures and is characterized by having a fusion involving the nuclear protein in testis, NUT, gene. Nuclear
Safwan K. Elkhatib, Beth K. Neilsen, Richard L. Sleightholm, Michael J. Baine, Weining Zhen   +4 more
doaj   +1 more source

Clinical progress and pharmacology of small molecule bromodomain inhibitors [PDF]

, 2016
Bromodomains have emerged as an exciting target class for drug discovery over the past decade. Research has primarily focused on the bromodomain and extra terminal (BET) family of bromodomains, which has led to the development of multiple small molecule ...
Humphreys, Philip G, Prinjha, Rab K, Theodoulou, Natalie H, Tomkinson, Nicholas CO   +3 more
core   +1 more source

NSD3-NUTM1-rearranged carcinoma of the median neck/thyroid bed developing after recent thyroidectomy for sclerosing mucoepidermoid carcinoma with eosinophilia: report of an extraordinary case [PDF]

, 2023
Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is an exceedingly rare low-grade thyroid malignancy of unknown histogenesis. NUT carcinoma is another rare, highly aggressive neoplasm with predilection for the midline, defined by recurrent ...
Agaimy, Abbas, Hartmann, Arndt, Mantsopoulos, Konstantinos, Meidenbauer, Norbert, Semrau, Sabine, Stoehr, Robert, Tögel, Lars   +6 more
core   +2 more sources

Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction [PDF]

, 2016
The bromodomain and extraterminal domain (BET) protein family are promising therapeutic targets for a range of diseases linked to transcriptional activation, cancer, viral latency, and viral integration.
Crowe, Brandon L., Foster, Mark P., Hess, Sonja, Kvaratskhelia, Mamuka, Larue, Ross C., Yuan, Chunhua   +5 more
core   +2 more sources

Identification of a novel BET bromodomain inhibitor-sensitive, gene regulatory circuit that controls Rituximab response and tumour growth in aggressive lymphoid cancers.: CYCLON-induced Rituximab resistance [PDF]

, 2013
International audienceImmuno-chemotherapy elicit high response rates in B-cell non-Hodgkin lymphoma but heterogeneity in response duration is observed, with some patients achieving cure and others showing refractory disease or relapse.
Alexandra Debernardi, Anouk Emadali, Benoit Bernay, Carlo Petosa, Charles E. McKenna, Christophe Bruley, Claire Rome, Dominique Leroux, Elena Ferri, Florence Combes, Friedberg JW, Juliana Bruder‐Costa, Jérôme Garin, Kato M, Mary B. Callanan, Myriam Ferro, Patricia Betton, Rousseaux S, Rémy Gressin, Saadi Khochbin, Samuel Duley, Sieme Hamaidia, Sophie Rousseaux, Swerdlow SH, Sylvie Kieffer‐Jaquinod   +24 more
core   +4 more sources

p63-negative thoracic NUT carcinoma - A potential diagnostic pitfall

Indian Journal of Pathology and Microbiology
NUT carcinoma is a rare, aggressive, undifferentiated carcinoma characterized by NUTM1 gene rearrangement. It was formerly termed NUT midline carcinoma due to its propensity to occur in midline anatomical structures.
K R Anila, S M Kaviya, T Priyakumari, K Jayasree   +3 more
doaj   +1 more source

Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy

BMC Cancer, 2006
Background Poorly differentiated midline carcinoma with a translocation between chromosomes 15 and 19, i.e. t(15;19), has been recognized as a distinct clinical entity for over a decade.
Dahlén Anna, Panagopoulos Ioannis, Soller Maria, Engleson Jens, Dictor Michael, Jerkeman Mats   +5 more
doaj   +1 more source