Results 61 to 70 of about 2,580 (202)

From transcriptional regulation to drugging the cancer epigenome [PDF]

, 2014
Jay Bradner discusses the opportunities and challenges for the study and therapeutic targeting of the cancer epigenome, as well as innovative approaches to drug ...
Bradner, James E
core   +2 more sources

Diagnosis of NUT Midline Carcinoma Using a NUT-specific Monoclonal Antibody [PDF]

American Journal of Surgical Pathology, 2009
NUT midline carcinoma (NMC) is a uniformly lethal malignancy that is defined by rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14. NMCs are morphologically indistinguishable from other poorly differentiated carcinomas, and the diagnosis is usually made currently by fluorescence in situ hybridization (FISH).
Herbert, Haack, Laura A, Johnson, Christopher J, Fry, Katherine, Crosby, Roberto D, Polakiewicz, Edward B, Stelow, Seung-Mo, Hong, Brian E, Schwartz, Michael J, Cameron, Mark A, Rubin, Martin C, Chang, Jon C, Aster, Christopher A, French   +12 more
openaire   +2 more sources

Nuclear protein in testis (NUT) carcinoma in the public sector of the Free State province, South Africa

South African Journal of Oncology, 2020
Background: Nuclear protein in testis (NUT) carcinoma (NC) is a rare tumour easily mistaken for a number of other tumours if a NUT immunohistochemical stain is not performed, and there is no high index of suspicion.
Antoinette E. Roets, Shireen Pretorius, Gina Joubert, Nicholas Pearce, Jacqueline Goedhals   +4 more
doaj   +1 more source

Multitarget Drugs: an Epigenetic Epiphany [PDF]

, 2016
Epigenetics refers to changes in a biological phenotype that are not due to an underlying change in genotype. In eukaryotes, epigenetics involves a set of chemical modifications of the DNA and the histone proteins in nucleosomes.
Atkinson, Baell, Baud, Beckers, Bentley, Blagodatski, Borretto, Bowman, Brand, Burg, Cai, Chen, Chen, Chen, Chen, Ciceri, Dancy, Deans, Fahy, Filippakopoulos, Finley, Fischer, Fuhrmann, Galloway, Gjertsen, Griffith, Guerrant, Guerrant, Hantschel, He, Huang, Hui, Hurley, Jing, Kaniskan, Kingston, Ko, Kortüm, Kozikowski, Lamblin, Lan, Ling, Liu, Lu, Lu, Maes, Mahboobi, Mahboobi, Mai, McGinty, McPherson, Micelli, Moore, Mottamal, Pachaiyappan, Pastor, Patel, Pereira, Pińa, Qian, Rask-Andersen, Rose, Rothbart, Rotili, Saijo, Saijo, Samatar, Schapira, Suganuma, Tavera-Mendoza, Villalba, Wagner, Winter, Wright, Yu, Yuan, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zuo, Álvarez   +84 more
core   +1 more source

YAP1-NUTM1 Gene Fusion in Porocarcinoma of the External Auditory Canal [PDF]

, 2023
Gene fusions involving the NUTM1 gene (NUT) represent defining genetic markers of a highly aggressive carcinoma type with predilection for the midline structures of children and young adults, hence the original description as NUT midline carcinoma ...
Agaimy, Abbas, Haller, Florian, Hornung, Joachim, Märkl, Bruno, Tögel, Lars, Zenk, Johannes   +5 more
core   +2 more sources

Sinonasal NUT midline carcinoma: A new histological entity

Indian Journal of Pathology and Microbiology, 2020
Nuclear protein in testis (NUT) midline carcinoma is poorly differentiated carcinoma defined by rearrangement of NUT gene on 15 to other genes, usually BRD4 on 19. It is first described in 1991. These tumors are most commonly seen in the mediastinum and 35% occur in head and neck.
Pragya N, Vakani, Jainil, Maheshwari, Mukesh, Maheshwari, Bhoomi, Shah   +3 more
openaire   +2 more sources

NUT Midline Carcinoma in a Pregnant Woman [PDF]

, 2014
NUT midline carcinoma is a rare, highly aggressive tumor that involves midline structures, particularly in the head, neck and mediastinum. It is characterized by NUT gene translocations on chromosome 15.
Bilyk, Jurij R., Cognetti, MD, David M., D\u27Souza, MD, Jill N., Evans, MD, James J., Heffelfinger, MD, Ryan N., Rosen, MD, Marc R., Tuluc, MD, Madalina   +6 more
core   +1 more source

NUT carcinoma of the submandibular gland: A case report [PDF]

, 2023
Background: NUT carcinoma (NUTc) is a rare and aggressive malignant epithelial tumor characterized by rearrangement of the NUT gene on chromosome 15q14.
Calareso G., Cavalieri S., Centonze G., Colombo E., Dagrada G., Franceschini M., Iacovelli N. A., Nuzzolese I., Ottini A., Perrone F., Quattrone P., Rota S., Tamborini E.   +12 more
core   +1 more source

Immunotherapy experience in sinonasal NUT midline carcinoma, case report

Journal of Cancer Research and Therapeutics, 2023
NUT midline carcinoma (NMC) is an aggressive malignant neoplasm arising from midline structures. Although it is classified as a rare disease, the pathological nonspecific appearance as undifferentiated/poorly differentiated carcinoma and the difficulty in making the definitive diagnosis are probably the reasons for the underdiagnosis; the disease is ...
Burcu, Caner, Sibel O, Orhan, Adem, Deligonul, Turkkan, Evrensel   +3 more
openaire   +2 more sources

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source