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Supraglottic NUT Carcinoma: A Case Report and Literature Review
Case Reports in Oncology, 2022 Nuclear protein of the testis (NUT) carcinoma is a very rare cancer that occurs in relatively young patients. In this study, we experienced a case of laryngeal NUT carcinoma that followed a rapid course.
Masaaki Higashino +3 more
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Cancer Genetics and Cytogenetics, 2010 NUT midline carcinoma (NMC) is a rare, aggressive human cancer, genetically defined by rearrangements of the gene NUT (HUGO symbol: C15orf55). In the majority (∼75%) of NMCs, most of the coding sequence of NUT on chromosome 15q14 is fused with BRD4 creating chimeric genes that encode BRD-NUT fusion proteins. In the remaining cases, NUT is fused to BRD3
openaire +5 more sources
NUT Carcinoma of the Lung：A Case report and Literature Analysis
Frontiers in Oncology, 2022 NUT carcinoma is a rare, highly aggressive cancer that feature as the rearrangement of the nuclear protein in the testis (NUT) gene on chromosome 15q14, and its pathogenesis and treatment is not yet clear.
Rongshuang Zhao +5 more
doaj +1 more source
NUT Carcinoma—An Underdiagnosed Malignancy
Frontiers in Oncology, 2022 NUT carcinoma (NC) is a rare and highly aggressive malignancy with a dismal prognosis and a median survival of 6–9 months only. Although very few cases of NC are reported each year, the true prevalence is estimated to be much higher, with NC potentially widely underdiagnosed due to the lack of awareness.
Ulrich M. Lauer +13 more
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Thoracic Cancer, 2020 Background Nuclear protein in testis (NUT) carcinoma is a rare tumor associated with NUT rearrangement that can present as poorly differentiated to undifferentiated carcinoma, with or without abrupt squamous differentiation.
Yoon Ah Cho +5 more
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Thoracic Cancer, 2020 Nuclear protein in testis (NUT) carcinoma is a rare, aggressive carcinoma that is a diagnostic challenge for pathologists. Here, we report a case of NUT carcinoma in a 63‐year‐old woman with uncommon immunohistochemical results. The initial bronchoscopic
Hwa Jin Cho, Hyun‐Kyung Lee
doaj +1 more source
Supercharging BRD4 with NUT in carcinoma
Oncogene, 2021 NUT carcinoma (NC) is an extremely aggressive squamous cancer with no effective therapy. NC is driven, most commonly, by the BRD4-NUT fusion oncoprotein. BRD4-NUT combines the chromatin-binding bromo- and extraterminal domain-containing (BET) protein, BRD4, with an unstructured, poorly understood protein, NUT, which recruits and activates the histone ...
Kyle P. Eagen, Christopher A. French
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P63-negative pulmonary NUT carcinoma arising in the elderly: a case report
Diagnostic Pathology, 2020 Background Pulmonary NUT carcinoma is rare, but lethal, thus, must not be overlooked. The definitive diagnosis is made by a NUT monoclonal antibody or gene analysis, but these are not always routinely available.
Satoe Numakura +12 more
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Frontiers in Oncology, 2023 BackgroundNuclear protein of the testis (NUT) carcinoma is a rare subset of poorly differentiated, highly aggressive malignancy defined by NUTM1 gene rearrangements.
Huahua Jiang +12 more
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NUT Carcinoma of the Sublingual Gland [PDF]
Head and Neck Pathology, 2015 NUT carcinoma (NC) is a recently described, rare and extremely aggressive cancer primarily located to supradiaphragmatic structures and affecting young individuals. NC is characterized by translocations involving the NUT gene on 15q14 with the most common translocation partner gene being BRD4 on 19p13, resulting in the t(15;19)(q14;p13) karyotype.
S. Andreasen +4 more
openaire +3 more sources