Results 11 to 20 of about 9,420 (171)

NUT carcinoma of the head and neck: A case report and literature review [PDF]

Precision Radiation Oncology
Nuclear protein in testis (NUT) carcinoma is a rare and highly aggressive cancer, characterized by rearrangements involving the NUT gene located on chromosome 15q14.
Yue Zhao, Jun Zhang, Wenjun Liao, Jiayu Li, Shichuan Zhang   +4 more
doaj   +2 more sources

NUT carcinoma of the upper respiratory tract: Two case reports and literature review [PDF]

Science Progress
NUT carcinoma is a rare and highly aggressive malignancy characterized by the rearrangement of the NUTM1 gene. It typically arises in midline structures, including the respiratory tract. Due to its rarity and poor prognosis, early diagnosis and effective
Ya Jiang, Xiaofeng Xie, Ziran Gao, Chaohui Zhang, Qiang Feng, Yuanyuan Wang, Wenmang Xu   +6 more
doaj   +2 more sources

The BRD4-NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma. [PDF]

Cancer Res, 2023
Abstract NUT carcinoma (NC) is an aggressive squamous carcinoma defined by the BRD4–NUT fusion oncoprotein. Routinely effective systemic treatments are unavailable for most NC patients.
Durall RT, Huang J, Wojenski L, Huang Y, Gokhale PC, Leeper BA, Nash JO, Ballester PL, Davidson S, Shlien A, Sotirakis E, Bertaux F, Dubus V, Luo J, Wu CJ, Keskin DB, Eagen KP, Shapiro GI, French CA.   +18 more
europepmc   +4 more sources

A Rare Case of NUT Carcinoma of the Thyroid. [PDF]

JCEM Case Rep
Abstract NUT carcinoma is an aggressive, poorly differentiated squamous cell carcinoma, defined by rearrangement of the NUTM1 (Nuclear Protein in Testis) gene. Diagnosis is challenging due to histologic similarities with other poorly differentiated tumors requiring advanced diagnostic techniques.
Cadesky A, Schulman-Rosenbaum R, Carter A, Paul E, Jaggi S.   +4 more
europepmc   +3 more sources

Complete Response to BET Inhibitor in Primary Pulmonary NUT Carcinoma With Single-Cell Sequencing-Based Analysis: A Case Report [PDF]

JTO Clinical and Research Reports
NUT carcinoma is a rare and highly aggressive malignancy characterized by rapid progression, resistance to conventional therapies, and an extremely poor prognosis. This report presents a 36-year-old patient with stage IIIB primary pulmonary NUT carcinoma
Zhuomiao Ye, MD, Xin Li, PhD, Minghui Zhang, PhD, Fei Xie, MD, Xiangwen Luo, MSc, Chao Deng, MD, Dan Yang, MSc, Mingzhu Yin, PhD   +7 more
doaj   +2 more sources

Brd4::Nutm1 fusion gene initiates NUT carcinoma in vivo [PDF]

Life Science Alliance
This study developed the first GEMM for NUT carcinoma to syntenically recapitulate the t(15;19) chromosome translocation in humans, serving as a critical preclinical model for the disease.
Dejin Zheng, Ahmed A Elnegiry, Chenxiang Luo, Mohammed Amine Bendahou, Liangqi Xie, Diana Bell, Yoko Takahashi, Ehab Hanna, George I Mias, Mayra F Tsoi, Bin Gu   +10 more
doaj   +2 more sources

Pulmonary Nuclear protein in Testis (NUT) carcinoma: clinical, molecular characteristics, and treatment strategies [PDF]

BMC Cancer
Background Pulmonary nuclear protein in testis (NUT) carcinoma is a rare and aggressive malignancy that often exhibits clinical and pathological features overlapping with other thoracic malignancies, posing significant challenges for accurate diagnosis ...
Jingjing Qu, Zhen Chen, Yanping Zhu, JinYan Huang, Qian Shen   +4 more
doaj   +2 more sources

Challenging Diagnosis in NUT Carcinoma [PDF]

International Journal of Surgical Pathology, 2021
Nuclear protein in testis (NUT) carcinoma represents a highly aggressive, poorly differentiated carcinoma that is genetically defined by rearrangement of NUT gene. The histomorphological appearance ranges from entirely undifferentiated carcinoma to carcinoma with prominent squamous differentiation.
Grosse, Claudia, Grosse, Alexandra
openaire   +3 more sources

Nuclear protein in testis carcinoma of the lung

Translational Oncology, 2023
Nuclear protein in testis (NUT) carcinoma is a kind of highly aggressive and fatal solid tumor characterized by a rearrangement of the NUT carcinoma family member 1 (NUTM1) gene located on chromosome 15 q l4, where the most common form of fusion is BRD4 ...
Jing Chen, Meihui Li, Hongyang Lu
doaj   +1 more source

A Case Report of Primary Pulmonary NUT Carcinoma and Literature Review

Chinese Journal of Lung Cancer, 2021
NUT carcinoma is a rare, high lethal cancer which feature as the rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14, and its pathogenesis and treatment is not yet clear, the prognosis is poor.
Xiaoqin LIU, Yanying LI, Min YU, Lin ZHOU   +3 more
doaj   +1 more source