Results 11 to 20 of about 9,223 (166)

Novel BRD2::NUTM1 Fusion in NUT Carcinoma With Exceptional Response to Chemotherapy: A Case Report [PDF]

JTO Clinical and Research Reports
We present the first known case of a patient with BRD2::NUTM1-driven NUT carcinoma. A 59-year-old woman presented with poorly differentiated squamous cell lung cancer metastatic to the pleura.
Sarah J. Wu, MD, PhD, Justin J. Kim, Yeying Huang, BS, R. Taylor Durall, BS, Simone Becker, RN, Stephanie Canty, CNP, MSN, Stefania Molinaro, BS, Evan Pisick, MD, Geoffrey I. Shapiro, MD, PhD, Christopher A. French, MD, Jia Luo, MD   +10 more
doaj   +2 more sources

Etoposide and cisplatin in combination with anlotinib for lung NUT carcinoma: a case report [PDF]

Frontiers in Oncology
Lung NUT carcinoma is a rare malignant tumor, which is highly aggressive, poorly differentiated, and difficult to recognize at an early stage, and is associated with very rare reports and extremely poor prognosis, with some reports showing a mOS of only ...
Yuxing Sun, Jiangyu Bian, Linfeng Wang, Tong Zhang   +3 more
doaj   +2 more sources

Research Progress on Pathogenesis and Treatment of NUT Carcinoma [PDF]

Chinese Journal of Lung Cancer
NUT carcinoma (nuclear protein in testis carcinoma) is a rare and highly invasive malignant tumor, which is most common in midline organs and lungs. The characteristic genetic change of NUT carcinoma is the rearrangement of NUT middle carcinoma family ...
Jiaxin DU, Xinwei ZHANG
doaj   +2 more sources

Complete Response to BET Inhibitor in Primary Pulmonary NUT Carcinoma With Single-Cell Sequencing-Based Analysis: A Case Report [PDF]

JTO Clinical and Research Reports
NUT carcinoma is a rare and highly aggressive malignancy characterized by rapid progression, resistance to conventional therapies, and an extremely poor prognosis. This report presents a 36-year-old patient with stage IIIB primary pulmonary NUT carcinoma
Zhuomiao Ye, MD, Xin Li, PhD, Minghui Zhang, PhD, Fei Xie, MD, Xiangwen Luo, MSc, Chao Deng, MD, Dan Yang, MSc, Mingzhu Yin, PhD   +7 more
doaj   +2 more sources

Brd4::Nutm1 fusion gene initiates NUT carcinoma in vivo [PDF]

Life Science Alliance
This study developed the first GEMM for NUT carcinoma to syntenically recapitulate the t(15;19) chromosome translocation in humans, serving as a critical preclinical model for the disease.
Dejin Zheng, Ahmed A Elnegiry, Chenxiang Luo, Mohammed Amine Bendahou, Liangqi Xie, Diana Bell, Yoko Takahashi, Ehab Hanna, George I Mias, Mayra F Tsoi, Bin Gu   +10 more
doaj   +2 more sources

Pulmonary Nuclear protein in Testis (NUT) carcinoma: clinical, molecular characteristics, and treatment strategies [PDF]

BMC Cancer
Background Pulmonary nuclear protein in testis (NUT) carcinoma is a rare and aggressive malignancy that often exhibits clinical and pathological features overlapping with other thoracic malignancies, posing significant challenges for accurate diagnosis ...
Jingjing Qu, Zhen Chen, Yanping Zhu, JinYan Huang, Qian Shen   +4 more
doaj   +2 more sources

Pulmonary NUT carcinoma, an elusive and refractory entity, shows transient response to chemotherapeutics and PD-1 inhibitor: a case report and literature review [PDF]

Frontiers in Immunology
Nuclear protein of the testis (NUT) carcinoma (NC) is a rare but highly aggressive disease, characterized by drug resistance and poor prognosis. This report describes the case of a 32-year-old male patient diagnosed to have pulmonary NC; the tumor ...
Guangjian Yang, Runze Liu, Linke Yang, Xue Yang, Xiaoyong Tang, Huiqing Mao   +5 more
doaj   +2 more sources

Maxillary Sinus NUT Carcinoma: A Case Report. [PDF]

Cancer Diagn Progn
Background/Aim: Nuclear protein in testis (NUT) carcinoma is extremely rare, occurs in the midline of the body, progresses rapidly and is refractory to treatment; most patients die within a year. Here, we describe a case of maxillary sinus NUT carcinoma presenting with epistaxis and nasal obstruction that was treated as a standard head and neck ...
Arai S, Tomioka R, Ueda Y, Shimizu A, Okamoto I, Tsukahara K.   +5 more
europepmc   +3 more sources

Challenging Diagnosis in NUT Carcinoma [PDF]

International Journal of Surgical Pathology, 2021
Nuclear protein in testis (NUT) carcinoma represents a highly aggressive, poorly differentiated carcinoma that is genetically defined by rearrangement of NUT gene. The histomorphological appearance ranges from entirely undifferentiated carcinoma to carcinoma with prominent squamous differentiation.
Grosse, Claudia, Grosse, Alexandra
openaire   +3 more sources

Nuclear protein in testis carcinoma of the lung

Translational Oncology, 2023
Nuclear protein in testis (NUT) carcinoma is a kind of highly aggressive and fatal solid tumor characterized by a rearrangement of the NUT carcinoma family member 1 (NUTM1) gene located on chromosome 15 q l4, where the most common form of fusion is BRD4 ...
Jing Chen, Meihui Li, Hongyang Lu
doaj   +1 more source