Results 11 to 20 of about 9,390 (183)

The BRD4-NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma. [PDF]

Cancer Res, 2023
Abstract NUT carcinoma (NC) is an aggressive squamous carcinoma defined by the BRD4–NUT fusion oncoprotein. Routinely effective systemic treatments are unavailable for most NC patients.
Durall RT, Huang J, Wojenski L, Huang Y, Gokhale PC, Leeper BA, Nash JO, Ballester PL, Davidson S, Shlien A, Sotirakis E, Bertaux F, Dubus V, Luo J, Wu CJ, Keskin DB, Eagen KP, Shapiro GI, French CA.   +18 more
europepmc   +4 more sources

NUT carcinoma of the upper respiratory tract: Two case reports and literature review. [PDF]

Sci Prog
NUT carcinoma is a rare and highly aggressive malignancy characterized by the rearrangement of the NUTM1 gene. It typically arises in midline structures, including the respiratory tract. Due to its rarity and poor prognosis, early diagnosis and effective
Jiang Y, Xie X, Gao Z, Zhang C, Feng Q, Wang Y, Xu W.   +6 more
europepmc   +2 more sources

NUT carcinoma of the head and neck: A case report and literature review. [PDF]

Precis Radiat Oncol
Nuclear protein in testis (NUT) carcinoma is a rare and highly aggressive cancer, characterized by rearrangements involving the NUT gene located on chromosome 15q14.
Zhao Y, Zhang J, Liao W, Li J, Zhang S.
europepmc   +2 more sources

Etoposide and cisplatin in combination with anlotinib for lung NUT carcinoma: a case report. [PDF]

Front Oncol
Lung NUT carcinoma is a rare malignant tumor, which is highly aggressive, poorly differentiated, and difficult to recognize at an early stage, and is associated with very rare reports and extremely poor prognosis, with some reports showing a mOS of only ...
Sun Y, Bian J, Wang L, Zhang T.
europepmc   +2 more sources

A Rare Case of NUT Carcinoma of the Thyroid. [PDF]

JCEM Case Rep
Abstract NUT carcinoma is an aggressive, poorly differentiated squamous cell carcinoma, defined by rearrangement of the NUTM1 (Nuclear Protein in Testis) gene. Diagnosis is challenging due to histologic similarities with other poorly differentiated tumors requiring advanced diagnostic techniques.
Cadesky A, Schulman-Rosenbaum R, Carter A, Paul E, Jaggi S.   +4 more
europepmc   +3 more sources

Complete Response to BET Inhibitor in Primary Pulmonary NUT Carcinoma With Single-Cell Sequencing-Based Analysis: A Case Report. [PDF]

JTO Clin Res Rep
NUT carcinoma is a rare and highly aggressive malignancy characterized by rapid progression, resistance to conventional therapies, and an extremely poor prognosis. This report presents a 36-year-old patient with stage IIIB primary pulmonary NUT carcinoma
Ye Z, Li X, Zhang M, Xie F, Luo X, Deng C, Yang D, Yin M.   +7 more
europepmc   +2 more sources

<i>Brd4::Nutm1</i> fusion gene initiates NUT carcinoma in vivo. [PDF]

Life Sci Alliance
This study developed the first GEMM for NUT carcinoma to syntenically recapitulate the t(15;19) chromosome translocation in humans, serving as a critical preclinical model for the disease.
Zheng D, Elnegiry AA, Luo C, Bendahou MA, Xie L, Bell D, Takahashi Y, Hanna E, Mias GI, Tsoi MF, Gu B.   +10 more
europepmc   +2 more sources

[Research Progress on Pathogenesis and Treatment of NUT Carcinoma]. [PDF]

Zhongguo Fei Ai Za Zhi
NUT carcinoma (nuclear protein in testis carcinoma) is a rare and highly invasive malignant tumor, which is most common in midline organs and lungs. The characteristic genetic change of NUT carcinoma is the rearrangement of NUT middle carcinoma family ...
Du J, Zhang X.
europepmc   +2 more sources

Pulmonary Nuclear protein in Testis (NUT) carcinoma: clinical, molecular characteristics, and treatment strategies. [PDF]

BMC Cancer
Background Pulmonary nuclear protein in testis (NUT) carcinoma is a rare and aggressive malignancy that often exhibits clinical and pathological features overlapping with other thoracic malignancies, posing significant challenges for accurate diagnosis ...
Qu J, Chen Z, Zhu Y, Huang J, Shen Q.
europepmc   +2 more sources

Challenging Diagnosis in NUT Carcinoma [PDF]

International Journal of Surgical Pathology, 2021
Nuclear protein in testis (NUT) carcinoma represents a highly aggressive, poorly differentiated carcinoma that is genetically defined by rearrangement of NUT gene. The histomorphological appearance ranges from entirely undifferentiated carcinoma to carcinoma with prominent squamous differentiation.
Grosse, Claudia, Grosse, Alexandra
openaire   +3 more sources