Results 61 to 70 of about 9,390 (183)

NUT carcinoma: A rare presentation of a chest mass with hypercalcemia in a pediatric patient

Human Pathology Reports, 2023
The most common etiologies for chest masses in children include neurogenic tumors, germ cell tumors, leukemia/lymphoma and cysts [1]. Hypercalcemia of malignancy can complicate the clinical course, but is rare in children and most likely to occur in ...
Amanda K. Johnson, Travis Johnson, Katrina Winsnes, Jessica L. Davis   +3 more
doaj   +1 more source

A sample size analysis of a mathematical model of longitudinal tumor volume and progression‐free survival for Bayesian individual dynamic predictions in recurrent high‐grade glioma

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 495-509, March 2025.
Abstract Patients with recurrent high‐grade glioma (rHGG) have a poor prognosis with median progression‐free survival (PFS) of <7 months. Responses to treatment are heterogenous, suggesting a clinical need for prognostic models. Bayesian data analysis can exploit individual patient follow‐up imaging studies to adaptively predict the risk of progression.
Daniel J. Glazar, Solmaz Sahebjam, Hsiang‐Husan M. Yu, Dung‐Tsa Chen, Menal Bhandari, Heiko Enderling   +5 more
wiley   +1 more source

Novel BRD2::NUTM1 Fusion in NUT Carcinoma With Exceptional Response to Chemotherapy: A Case Report

JTO Clinical and Research Reports
We present the first known case of a patient with BRD2::NUTM1-driven NUT carcinoma. A 59-year-old woman presented with poorly differentiated squamous cell lung cancer metastatic to the pleura.
Sarah J. Wu, MD, PhD, Justin J. Kim, Yeying Huang, BS, R. Taylor Durall, BS, Simone Becker, RN, Stephanie Canty, CNP, MSN, Stefania Molinaro, BS, Evan Pisick, MD, Geoffrey I. Shapiro, MD, PhD, Christopher A. French, MD, Jia Luo, MD   +10 more
doaj   +1 more source

Genomic profiling of solid tumors harboring BRD4-NUT and response to immune checkpoint inhibitors

Translational Oncology, 2021
Background: The translocation t(15:19) produces the oncogenic BRD4-NUT fusion which is pathognomonic for NUT carcinoma (NC), which is a rare, but extremely aggressive solid tumor.
Jonathan W. Riess, Shaila Rahman, Waleed Kian, Claire Edgerly, Andreas M. Heilmann, Russell Madison, Shakti H. Ramkissoon, Shai Shlomi Klaitman, Jon H. Chung, Sally E. Trabucco, Dexter X. Jin, Brian M. Alexander, Samuel J. Klempner, Lee A. Albacker, Garrett M. Frampton, Laila C. Roisman, Vincent A. Miller, Jeffrey S. Ross, Alexa B. Schrock, Jeffrey P. Gregg, Nir Peled, Ethan S. Sokol, Siraj M. Ali   +22 more
doaj   +1 more source

NUT Midline Carcinomas of the Sinonasal Tract [PDF]

American Journal of Surgical Pathology, 2012
NUT midline carcinoma (NMC) is a highly lethal tumor defined by translocations involving the NUT gene on chromosome 15q14. NMC involves midline structures including the sinonasal tract, but its overall incidence at this midline site and its full morphologic profile are largely unknown because sinonasal tumors are not routinely tested for the NUT gene ...
Justin A, Bishop, William H, Westra
openaire   +2 more sources

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

NUT carcinoma

Indian Journal of Pathology and Microbiology, 2023
Mohammed, Shahin, Krushna Kumari, Sahoo, Ephraim, Rebba, Mahesh, Sultania, Madhabananda, Kar, Mukund, Sable   +5 more
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Neuroendocrine and squamous cell phenotypes of NUT carcinoma are potential diagnostic pitfalls that discriminating it from mimickers, such as small cell and squamous cell carcinoma

Diagnostic Pathology
Introduction NUT carcinoma is a rare cancer associated with a poor prognosis. Because of its rarity, its diagnosis is challenging and is usually made by excluding other diagnoses. Immunohistochemical analysis is a reliable technique that contributes to a
Hironori Ninomiya, Yukiko Sato, Kentaro Inamura, Akito Dobashi, Kengo Takeuchi, Hiroki Mitani, Mingyon Mun, Makoto Nishio, Yuichi Ishikawa   +8 more
doaj   +1 more source

Diagnosis of NUT Midline Carcinoma Using a NUT-specific Monoclonal Antibody [PDF]

American Journal of Surgical Pathology, 2009
NUT midline carcinoma (NMC) is a uniformly lethal malignancy that is defined by rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14. NMCs are morphologically indistinguishable from other poorly differentiated carcinomas, and the diagnosis is usually made currently by fluorescence in situ hybridization (FISH).
Herbert, Haack, Laura A, Johnson, Christopher J, Fry, Katherine, Crosby, Roberto D, Polakiewicz, Edward B, Stelow, Seung-Mo, Hong, Brian E, Schwartz, Michael J, Cameron, Mark A, Rubin, Martin C, Chang, Jon C, Aster, Christopher A, French   +12 more
openaire   +2 more sources

A Retrospective Study of Two Mandibulectomy Approaches for T3‐Stage Lower Gingival Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study retrospectively analyzes two mandibular resection techniques for T3‐stage lower gingival carcinoma, aiming to compare their impact on patient prognosis. Methods Retrospective cohort study. Data from 78 cases of T3‐stage lower gingival carcinoma involving the mandible were reviewed in our Department of Head and Neck Surgery.
Hang Ling, Wen‐Xiao Huang, Wai‐Sheng Zhong, Hai‐Lin Zhang, Hong Peng, Jie Chen, Ping‐Qing Tan   +6 more
wiley   +1 more source