Results 31 to 40 of about 10,988 (206)

PEGylated Serp-1 Markedly Reduces Pristane-Induced Experimental Diffuse Alveolar Hemorrhage, Altering uPAR Distribution, and Macrophage Invasion

Frontiers in Cardiovascular Medicine, 2021
Diffuse alveolar hemorrhage (DAH) is one of the most serious clinical complications of systemic lupus erythematosus (SLE). The prevalence of DAH is reported to range from 1 to 5%, but while DAH is considered a rare complication there is a reported 50–80%
Qiuyun Guo, Qiuyun Guo, Jordan R. Yaron, John W. Wallen, Kyle F. Browder, Ryan Boyd, Tien L. Olson, Michelle Burgin, Peaches Ulrich, Emily Aliskevich, Lauren N. Schutz, Petra Fromme, Liqiang Zhang, Alexandra R. Lucas   +13 more
doaj   +1 more source

Mathematical model of optimal chemotherapy and oncolytic virotherapy

, 2020
In this paper, a mathematical model of fighting against cancer tumor growth by a combination of oncolytic virotherapy and chemotherapy is introduced. In this model, we considered two time delays τ1 and τ2.
Bahrampour, A, Shamsara, E, Esmaily, H
core   +1 more source

Recombinant Myxoma Virus-Derived Immune Modulator M-T7 Accelerates Cutaneous Wound Healing and Improves Tissue Remodeling

Pharmaceutics, 2020
Complex dermal wounds represent major medical and financial burdens, especially in the context of comorbidities such as diabetes, infection and advanced age.
Jordan R. Yaron, Liqiang Zhang, Qiuyun Guo, Enkidia A. Awo, Michelle Burgin, Lauren N. Schutz, Nathan Zhang, Jacquelyn Kilbourne, Juliane Daggett-Vondras, Kenneth M. Lowe, Alexandra R. Lucas   +10 more
doaj   +1 more source

Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1

Frontiers in Immunology, 2021
Immune checkpoint inhibitors such as anti-PD-1 have revolutionized the field of oncology over the past decade. Nevertheless, the majority of patients do not benefit from them.
Victor Cervera-Carrascon, Victor Cervera-Carrascon, Dafne C. A. Quixabeira, Joao M. Santos, Joao M. Santos, Riikka Havunen, Riikka Havunen, Ioanna Milenova, Ioanna Milenova, Jan Verhoeff, Camilla Heiniö, Sadia Zafar, Juan J. Garcia-Vallejo, Victor W. van Beusechem, Tanja D. de Gruijl, Aino Kalervo, Suvi Sorsa, Anna Kanerva, Anna Kanerva, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki   +21 more
doaj   +1 more source

Cancer immunotherapy via combining oncolytic virotherapy with chemotherapy: recent advances [PDF]

, 2016
Oncolytic viruses are multifunctional anticancer agents with huge clinical potential, and have recently passed the randomized Phase III clinical trial hurdle.
Relph, KL, Harrington, K, Pandha, H, Simpson, GR, Melcher, A   +4 more
core   +1 more source

Melanoma Unknown Primary Brain Metastasis Treatment with ECHO-7 Oncolytic Virus Rigvir: A Case Report

Frontiers in Oncology, 2018
Melanoma is considered an aggressive malignancy with a tendency of forming metastasis in the brain. Less than 10% of all melanoma cases present with unknown primary tumor location.
Guna Proboka, Andra Tilgase, Sergejs Isajevs, Sergejs Isajevs, Agnija Rasa, Pēteris Alberts   +5 more
doaj   +1 more source

A Highly Expressing, Soluble, and Stable Plant-Made IgG Fusion Vaccine Strategy Enhances Antigen Immunogenicity in Mice Without Adjuvant

Frontiers in Immunology, 2020
Therapeutics based on fusing a protein of interest to the IgG Fc domain have been enormously successful, though fewer studies have investigated the vaccine potential of IgG fusions.
Andrew G. Diamos, Andrew G. Diamos, Mary D. Pardhe, Mary D. Pardhe, Haiyan Sun, Haiyan Sun, Joseph G. L. Hunter, Joseph G. L. Hunter, Jacquelyn Kilbourne, Jacquelyn Kilbourne, Qiang Chen, Qiang Chen, Hugh S. Mason, Hugh S. Mason   +13 more
doaj   +1 more source

Lung cancer and oncolytic virotherapy——enemy's enemy

Translational Oncology, 2023
Lung cancer is one of the malignant tumors that seriously threaten human health worldwide, while the covid-19 virus has become people's nightmare after the coronavirus pandemic. There are too many similarities between cancer cells and viruses, one of the
Zhang Li, Zhang Feiyue, Li Gaofeng, Liang Haifeng   +3 more
doaj   +1 more source

Mathematical Models in Oncolytic Virotherapy and Immunology [PDF]

, 2021
In this thesis we build mathematical models to address fundamental questions in immunology and virotherapy. We begin with a study of T cell response to pathogens.
Pooladvand, Pantea
core  

Current strategies in engaging oncolytic viruses with antitumor immunity

Molecular Therapy: Oncolytics, 2021
Oncolytic virotherapy has produced promising yet limited results in preclinical and clinical studies. Besides direct oncolytic activity, a significant therapeutic mechanism of oncolytic virotherapy is the induction of tumor-specific immunity ...
Drew Ashton Boagni, Divya Ravirala, Shaun Xiaoliu Zhang   +2 more
doaj   +1 more source