Results 11 to 20 of about 11,703 (213)
Annals of Hepatology, 2008 Current oncolytic virotherapy strategies are based in the accumulated understanding of the common molecular mechanisms displayed during cell transformation and viral infection, like cell cycle and apoptosis deregulations.
Rocio Ortiz-López +1 more
exaly +6 more sources
Delivery and Biosafety of Oncolytic Virotherapy
Frontiers in Oncology, 2020 In recent years, oncolytic virotherapy has emerged as a promising anticancer therapy. Oncolytic viruses destroy cancer cells, without damaging normal tissues, through virus self-replication and antitumor immunity responses, showing great potential for ...
Duoduo Han, Bin Tang
exaly +4 more sources
Comparative safety and efficacy of oncolytic virotherapy for the treatment of individuals with malignancies: a systematic review, meta-analysis, and Bayesian network meta-analysisResearch in context [PDF]
EClinicalMedicineSummary: Background: Oncolytic virotherapy (OV) is an innovative immunotherapy strategy. A comprehensive understanding of oncolytic viruses is essential for advancing research and clinical practice.
Poyee Lau +4 more
doaj +3 more sources
Oncolytic Virotherapy for Melanoma Brain Metastases, a Potential New Treatment Paradigm?
Brain Sciences, 2021 Introduction: Melanoma brain metastases remain a devastating disease process with poor prognosis. Recently, there has been a surge in studies demonstrating the efficacy of oncolytic virotherapy for brain tumor treatment.
Sauson Soldozy +2 more
exaly +3 more sources
Oncolytic virotherapy-mediated anti-tumor response: a single-cell perspective
Cancer Cell, 2021 Talimogene laherparepvec (T-VEC) is a genetically modified herpes simplex 1 virus (HSV-1) approved for cancer therapy. We investigate its effect on the clinical, histological, single-cell transcriptomic, and immune repertoire level using repeated fine ...
Egle Ramelyte +2 more
exaly +2 more sources
Advances in oncolytic virotherapy
Communications Medicine, 2022 Recent years have seen rapid advances in the preclinical development and clinical evaluation of oncolytic (cancer-lysing) virus-based therapies, and these are emerging as treatment modality for some cancers.
Stephen J. Russell +3 more
doaj +3 more sources
Oncolytic virotherapy as immunotherapy
Science, 2021 Description Recognizing immune responses to oncolytic virotherapy opens the way for new combinations Oncolytic virus (OV) therapy is now something of a misnomer.
A. Melcher, K. Harrington, R. Vile
semanticscholar +3 more sources
Oncolytic Virotherapy: A New Paradigm in Cancer Immunotherapy
International Journal of Molecular SciencesOncolytic viruses (OVs) are emerging as potential treatment options for cancer. Natural and genetically engineered viruses exhibit various antitumor mechanisms.
Dragos-Viorel Scripcariu +2 more
exaly +2 more sources
Combination of oncolytic viruses and immune checkpoint inhibitors for treatment of high-grade gliomas [PDF]
Frontiers in NeurologyHigh-grade gliomas (HGG) such as glioblastoma are the most aggressive primary malignancies of the central nervous system. The median overall survival of glioblastoma is <15 months despite treatment with surgery, radiotherapy, and chemotherapy ...
Zhihong Qian +4 more
doaj +2 more sources
Frontiers in Immunology, 2023 IntroductionPancreatic ductal adenocarcinoma (PDAC) is largely refractory to cancer immunotherapy with PD-1 immune checkpoint blockade (ICB). Oncolytic virotherapy has been shown to synergize with ICB.
Rūta Veinalde +22 more
doaj +2 more sources