Results 11 to 20 of about 7,822 (173)

Advances in oncolytic virotherapy

Communications Medicine, 2022
Recent years have seen rapid advances in the preclinical development and clinical evaluation of oncolytic (cancer-lysing) virus-based therapies, and these are emerging as treatment modality for some cancers.
Stephen J. Russell, John C. Bell, Christine E. Engeland, Grant McFadden   +3 more
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Oncolytic virotherapy [PDF]

Nature Biotechnology, 2012
Oncolytic virotherapy is an emerging treatment modality that uses replication-competent viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a single-shot virotherapy cure, identification of drugs that accelerate intratumoral virus propagation, strategies to maximize the immunotherapeutic action of oncolytic viruses ...
Russell, Stephen J, Peng, Kah-Whye, Bell, John C   +2 more
openaire   +3 more sources

Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS2-N501Y_MA30 Strain of SARS-CoV-2

Vaccines, 2022
The Omicron SARS-CoV-2 variant has been designated as a variant of concern because its spike protein is heavily mutated. In particular, the Omicron spike is mutated at five positions (K417, N440, E484, Q493, and N501) that have been associated with ...
Karen V. Kibler, Mateusz Szczerba, Douglas Lake, Alexa J. Roeder, Masmudur Rahman, Brenda G. Hogue, Lok-Yin Roy Wong, Stanley Perlman, Yize Li, Bertram L. Jacobs   +9 more
doaj   +1 more source

Autologous Transplantation Using Donor Leukocytes Loaded Ex Vivo with Oncolytic Myxoma Virus Can Eliminate Residual Multiple Myeloma

Molecular Therapy: Oncolytics, 2020
Multiple myeloma (MM) is a hematological malignancy of monoclonal plasma cells that remains incurable. Standard treatments for MM include myeloablative regimens and autologous cell transplantation for eligible patients.
Nancy.Y. Villa, Masmudur M. Rahman, Joseph. Mamola, Julia D’Isabella, Elizabeth Goras, Jacquelyn Kilbourne, Kenneth Lowe, Juliane Daggett-Vondras, Lino Torres, John Christie, Nicole Appel, Anna L. Cox, Jae B. Kim, Grant McFadden   +13 more
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Longitudinal characterization of multispecies microbial populations recovered from spaceflight potable water

npj Biofilms and Microbiomes, 2021
While sequencing technologies have revolutionized our knowledge of microbial diversity, little is known about the dynamic emergent phenotypes that arise within the context of mixed-species populations, which are not fully predicted using sequencing ...
Jiseon Yang, Jennifer Barrila, C. Mark Ott, Olivia King, Rebekah Bruce, Robert J. C. McLean, Cheryl A. Nickerson   +6 more
doaj   +1 more source

Systemic delivery of TNF-armed myxoma virus plus immune checkpoint inhibitor eliminates lung metastatic mouse osteosarcoma

Molecular Therapy: Oncolytics, 2021
Solid cancers that metastasize to the lungs represent a major therapeutic challenge. Current treatment paradigms for lung metastases consist of radiation therapy, chemotherapies, and surgical resection, but there is no single treatment or combination ...
John D. Christie, Nicole Appel, Hannah Canter, Jazmin Galvan Achi, Natalie M. Elliott, Ana Lemos de Matos, Lina Franco, Jacquelyn Kilbourne, Kenneth Lowe, Masmudur M. Rahman, Nancy Y. Villa, Joshua Carmen, Evelyn Luna, Joseph Blattman, Grant McFadden   +14 more
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Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection

EMBO Molecular Medicine, 2023
SARS‐CoV‐2 acute respiratory distress syndrome (ARDS) induces uncontrolled lung inflammation and coagulopathy with high mortality. Anti‐viral drugs and monoclonal antibodies reduce early COVID‐19 severity, but treatments for late‐stage immuno‐thrombotic ...
Liqiang Zhang, Yize Henry Li, Karen Kibler, Simona Kraberger, Arvind Varsani, Julie Turk, Nora Elmadbouly, Emily Aliskevich, Laurel Spaccarelli, Bereket Estifanos, Junior Enow, Isabela Rivabem Zanetti, Nicholas Saldevar, Efrem Lim, Jessika Schlievert, Kyle Browder, Anjali Wilson, Fernando Arcos Juan, Aubrey Pinteric, Aman Garg, Henna Monder, Rohan Saju, Savanah Gisriel, Bertram Jacobs, Timothy L Karr, Esther Borges Florsheim, Vivek Kumar, John Wallen, Masmudur Rahman, Grant McFadden, Brenda G Hogue, Alexandra R Lucas   +31 more
doaj   +1 more source

Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics

mAbs, 2021
Cancer therapeutics approved for clinical application include oncolytic viruses and antibodies, which evolved by nature, but were improved by molecular engineering.
Roland E. Kontermann, Guy Ungerechts, Dirk M. Nettelbeck   +2 more
doaj   +1 more source

Case report: Immunovirotherapy as a novel add-on treatment in a patient with thoracic NUT carcinoma

Frontiers in Oncology, 2022
NUT carcinoma (NC) is a rare and extremely aggressive form of cancer, usually presenting with intrathoracic or neck manifestations in adolescents and young adults.
Linus D. Kloker, Branko Calukovic, Katrin Benzler, Alexander Golf, Sebastian Böhm, Sven Günther, Marius Horger, Simone Haas, Simone Haas, Susanne Berchtold, Julia Beil, Julia Beil, Mary E. Carter, Tina Ganzenmueller, Stephan Singer, Abbas Agaimy, Robert Stöhr, Arndt Hartmann, Thomas Duell, Sandra Mairhofer, Fabian Fohrer, Niels Reinmuth, Lars Zender, Lars Zender, Ulrich M. Lauer, Ulrich M. Lauer   +25 more
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Establishing a New Platform to Investigate the Efficacy of Oncolytic Virotherapy in a Human Ex Vivo Peritoneal Carcinomatosis Model

Viruses, 2023
Oncolytic virotherapy constitutes a promising treatment option for many solid cancers, including peritoneal carcinomatosis (PC), which still represents a terminal stage of many types of tumors.
Jana Koch, Julia Beil, Susanne Berchtold, Dina Mönch, Annika Maaß, Irina Smirnow, Andrea Schenk, Mary E. Carter, Linus D. Kloker, Tobias Leibold, Philipp Renner, Marc-H. Dahlke, Ulrich M. Lauer   +12 more
doaj   +1 more source