Results 11 to 20 of about 13,638 (219)
Annals of Hepatology, 2008 Current oncolytic virotherapy strategies are based in the accumulated understanding of the common molecular mechanisms displayed during cell transformation and viral infection, like cell cycle and apoptosis deregulations.
Daniel Cervantes-García; +3 more
doaj +4 more sources
The oncolytic virus dl922-947 reduces IL-8/CXCL8 and MCP-1/CCL2 expression and impairs angiogenesis and macrophage infiltration in anaplastic thyroid carcinoma [PDF]
Aging, 2015 Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human solid tumor and current treatments are ineffective in increasing patients' survival. Thus, the development of new therapeutic approaches for ATC is needed.
Ayyoub +71 more
core +9 more sources
Advances in oncolytic virotherapy
Communications Medicine, 2022 Recent years have seen rapid advances in the preclinical development and clinical evaluation of oncolytic (cancer-lysing) virus-based therapies, and these are emerging as treatment modality for some cancers.
Stephen J. Russell +3 more
doaj +3 more sources
Personalizing Oncolytic Virotherapy
Human Gene Therapy, 2023 The use of oncolytic viruses has become an attractive tool in the clinics for the treatment of various tumor types. Such viruses are genetically modified to conditionally replicate in malignant cells while unharming healthy cells. This platform offers a highly specific tumor killing with exceptional safety profiles.
Firas Hamdan +2 more
openaire +4 more sources
npj Biofilms and Microbiomes, 2021 While sequencing technologies have revolutionized our knowledge of microbial diversity, little is known about the dynamic emergent phenotypes that arise within the context of mixed-species populations, which are not fully predicted using sequencing ...
Jiseon Yang +6 more
doaj +1 more source
Oncolytic Virotherapy for Melanoma Brain Metastases, a Potential New Treatment Paradigm?
Brain Sciences, 2021 Introduction: Melanoma brain metastases remain a devastating disease process with poor prognosis. Recently, there has been a surge in studies demonstrating the efficacy of oncolytic virotherapy for brain tumor treatment.
Sauson Soldozy +12 more
doaj +1 more source
EMBO Molecular Medicine, 2023 SARS‐CoV‐2 acute respiratory distress syndrome (ARDS) induces uncontrolled lung inflammation and coagulopathy with high mortality. Anti‐viral drugs and monoclonal antibodies reduce early COVID‐19 severity, but treatments for late‐stage immuno‐thrombotic ...
Liqiang Zhang +31 more
doaj +1 more source
Case report: Immunovirotherapy as a novel add-on treatment in a patient with thoracic NUT carcinoma
Frontiers in Oncology, 2022 NUT carcinoma (NC) is a rare and extremely aggressive form of cancer, usually presenting with intrathoracic or neck manifestations in adolescents and young adults.
Linus D. Kloker +25 more
doaj +1 more source
Oncolytic Virotherapy Trials—Letter [PDF]
Clinical Cancer Research, 2013 We would like to thank Prof. Harrington for his insightful commentary ([1][1]) regarding our article by Kanerva and colleagues ([2][2]). During 2007–2011, the Advanced Therapy Access Program (ATAP) provided a unique opportunity for patients to access a technology they would not otherwise have ...
Hemminki Akseli +3 more
openaire +2 more sources
mAbs, 2021 Cancer therapeutics approved for clinical application include oncolytic viruses and antibodies, which evolved by nature, but were improved by molecular engineering.
Roland E. Kontermann +2 more
doaj +1 more source