Results 41 to 50 of about 11,703 (213)

Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy

Cell, 2017
SUMMARY Here we report a phase 1b clinical trial testing the impact of oncolytic virotherapy with talimogene laherparepvec on cytotoxic T cell infiltration and therapeutic efficacy of the anti-PD-1 antibody pembrolizumab.
A. Ribas, R. Dummer, I. Puzanov, A. VanderWalde, R. Andtbacka, O. Michielin, A. Olszanski, J. Malvehy, J. Cebon, Eugenio Fernandez, J. Kirkwood, T. Gajewski, Lisa Chen, K. Gorski, A. Anderson, Scott J. Diede, Michael E. Lassman, J. Gansert, F. Hodi, G. Long   +19 more
semanticscholar   +1 more source

Blockade of innate inflammatory cytokines TNFα, IL-1β, or IL-6 overcomes virotherapy-induced cancer equilibrium to promote tumor regression

Immunotherapy Advances, 2023
Summary Cancer therapeutics can lead to immune equilibrium in which the immune response controls tumor cell expansion without fully eliminating the cancer.
Michael J. Walsh, Lestat R. Ali, P. Lenehan, Courtney T S Kureshi, R. Kureshi, M. Dougan, D. Knipe, S. Dougan   +7 more
semanticscholar   +1 more source

Oncolytic virotherapy for ovarian cancer [PDF]

Oncolytic Virotherapy, 2012
In the past two decades, more than 20 viruses with selective tropism for tumor cells have been developed as oncolytic viruses (OVs) for treatments of a variety of malignancies. Of these viruses, eleven have been tested in human ovarian cancer models in preclinical studies.
Li, Shoudong, Tong, Jessica, Rahman, Masmudur M., Shepherd, Trevor G., McFadden, Grant   +4 more
openaire   +4 more sources

Recombinant Myxoma Virus-Derived Immune Modulator M-T7 Accelerates Cutaneous Wound Healing and Improves Tissue Remodeling

Pharmaceutics, 2020
Complex dermal wounds represent major medical and financial burdens, especially in the context of comorbidities such as diabetes, infection and advanced age.
Jordan R. Yaron, Liqiang Zhang, Qiuyun Guo, Enkidia A. Awo, Michelle Burgin, Lauren N. Schutz, Nathan Zhang, Jacquelyn Kilbourne, Juliane Daggett-Vondras, Kenneth M. Lowe, Alexandra R. Lucas   +10 more
doaj   +1 more source

Oncolytic virotherapy evolved into the fourth generation as tumor immunotherapy

Journal of Translational Medicine, 2023
Background Oncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues.
Xianwang Wang, Yihua Shen, X. Wan, Xiaoqing Hu, Wen-Qi Cai, Zijun Wu, Qiang Xin, Xiaoqi Liu, Jingang Gui, Hong-Yi Xin, Hong-Wu Xin   +10 more
semanticscholar   +1 more source

Lung cancer and oncolytic virotherapy——enemy's enemy

Translational Oncology, 2023
Lung cancer is one of the malignant tumors that seriously threaten human health worldwide, while the covid-19 virus has become people's nightmare after the coronavirus pandemic. There are too many similarities between cancer cells and viruses, one of the
Zhang Li, Zhang Feiyue, Li Gaofeng, Liang Haifeng   +3 more
doaj   +1 more source

Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer

Cancers, 2023
Simple Summary Head and neck cancer (HNC) is a significant global health issue, and traditional treatments such as surgery, chemotherapy, and radiation therapy often have limited success, especially in advanced cases. Oncolytic virotherapy (OVT) offers a
Zhan Wang, Peng Sun, Zhiyong Li, Shaowen Xiao   +3 more
semanticscholar   +1 more source

A Highly Expressing, Soluble, and Stable Plant-Made IgG Fusion Vaccine Strategy Enhances Antigen Immunogenicity in Mice Without Adjuvant

Frontiers in Immunology, 2020
Therapeutics based on fusing a protein of interest to the IgG Fc domain have been enormously successful, though fewer studies have investigated the vaccine potential of IgG fusions.
Andrew G. Diamos, Andrew G. Diamos, Mary D. Pardhe, Mary D. Pardhe, Haiyan Sun, Haiyan Sun, Joseph G. L. Hunter, Joseph G. L. Hunter, Jacquelyn Kilbourne, Jacquelyn Kilbourne, Qiang Chen, Qiang Chen, Hugh S. Mason, Hugh S. Mason   +13 more
doaj   +1 more source

Current strategies in engaging oncolytic viruses with antitumor immunity

Molecular Therapy: Oncolytics, 2021
Oncolytic virotherapy has produced promising yet limited results in preclinical and clinical studies. Besides direct oncolytic activity, a significant therapeutic mechanism of oncolytic virotherapy is the induction of tumor-specific immunity ...
Drew Ashton Boagni, Divya Ravirala, Shaun Xiaoliu Zhang   +2 more
doaj   +1 more source

PEGylated Serp-1 Markedly Reduces Pristane-Induced Experimental Diffuse Alveolar Hemorrhage, Altering uPAR Distribution, and Macrophage Invasion

Frontiers in Cardiovascular Medicine, 2021
Diffuse alveolar hemorrhage (DAH) is one of the most serious clinical complications of systemic lupus erythematosus (SLE). The prevalence of DAH is reported to range from 1 to 5%, but while DAH is considered a rare complication there is a reported 50–80%
Qiuyun Guo, Qiuyun Guo, Jordan R. Yaron, John W. Wallen, Kyle F. Browder, Ryan Boyd, Tien L. Olson, Michelle Burgin, Peaches Ulrich, Emily Aliskevich, Lauren N. Schutz, Petra Fromme, Liqiang Zhang, Alexandra R. Lucas   +13 more
doaj   +1 more source