Results 41 to 50 of about 10,988 (206)

Personalizing Oncolytic Virotherapy?

Molecular Therapy, 2007
raditionally, cancer therapies have been based on the empiric discovery of drugs and/or biological agents that act selectively against tumor cells. Recently, however, a generation of rationally discov-ered drugs and agents has been developed that shows encouraging benefi t in treating cancers.
Kaur, Balveen, Chiocca, E Antonio
openaire   +2 more sources

The Role of the Innate Immune System in Oncolytic Virotherapy [PDF]

, 2017
The complexity of the immune responses is a major challenge in current virotherapy. This study incorporates the innate immune response into our basic model for virotherapy and investigates how the innate immunity affects the outcome of virotherapy.
Tuan Anh Phan, Jianjun Paul Tian
core   +1 more source

Remote Control of Light-Triggered Virotherapy

, 2017
Clinical virotherapy has been successfully approved for use in cancer treatment by the U.S. Food and Drug Administration; however, a number of improvements are still sought to more broadly develop virotherapy.
楊泮池, Tseng, S-Ja;Huang, Kuo-Yen;Kempson, Ivan M.;Kao, Shih-Han;Liu, Meng-Chia;Yang, Shuenn-Chen;Liao, Zi-Xian;Yang, Pan-Chyr   +1 more
core   +1 more source

Implications of immune cells in oncolytic herpes simplex virotherapy for glioma [PDF]

, 2022
Despite current progress in treatment, glioblastoma (GBM) remains a lethal primary malignant tumor of the central nervous system. Although immunotherapy has recently achieved remarkable survival effectiveness in multiple malignancies, none of the immune ...
Yoo, Ji Young, Kaur, Balveen, Yoshihiro Otani, Toshihiko Shimizu, Date, Isao, Kazuhiko Kurozumi, Isao Date, Shimizu, Toshihiko, Kurozumi, Kazuhiko, Otani, Yoshihiro, Ji Young Yoo, Balveen Kaur   +11 more
core   +2 more sources

Oncolytic virotherapy: a potential therapeutic approach for cholesteatoma.

, 2020
PURPOSE OF REVIEW: To review the principles of oncolytic virotherapy and summarize the recent preliminary evidence on the efficacy of oncolytic virotherapy for cholesteatoma (CHST) treatment in vitro in human CHST cells and in a gerbil CHST model. RECENT
Lipschitz, Noga, Samy, Ravi N, MD, Earl, Brian R, Cripe, Timothy P   +3 more
core   +2 more sources

Enhanced Antitumor Activity and Induction of Immunogenic Cell Death in NUT Carcinoma Cells by Combining Oncolytic Viruses with the Dual Inhibitor NEO2734

Viruses
NUT carcinoma (NC) is a rare exceptionally aggressive malignancy, defined by NUTM1 gene translocations, most commonly generating a BRD4::NUTM1 fusion that results in a poor prognosis and limited therapeutic options. Oncolytic virotherapy has emerged as a
Fiona D. Nitschke, Julia Beil, Irina Smirnow, Andrea Schenk, Mary E. Carter, Ulrich M. Lauer, Linus D. Kloker   +6 more
doaj   +1 more source

Multimodal Therapy Approaches for NUT Carcinoma by Dual Combination of Oncolytic Virus Talimogene Laherparepvec with Small Molecule Inhibitors

Viruses
NUT (nuclear-protein-in-testis) carcinoma (NC) is a highly aggressive tumor disease. Given that current treatment regimens offer a median survival of six months only, it is likely that this type of tumor requires an extended multimodal treatment approach
Stavros Sotiriadis, Julia Beil, Susanne Berchtold, Irina Smirnow, Andrea Schenk, Ulrich M. Lauer   +5 more
doaj   +1 more source

Modeling dynamics of cancer virotherapy with immune response

Advances in Difference Equations, 2020
Virotherapy is a therapeutic treatment for cancer. It uses genetically engineered viruses to selectively infect, replicate in, and destroy cancer cells without damaging normal cells.
Salma M. Al-Tuwairqi, Najwa O. Al-Johani, Eman A. Simbawa   +2 more
doaj   +1 more source

Tumor treatment with chemo-virotherapy and MEK inhibitor: A mathematical model of Caputo fractional differential operator

Alexandria Engineering Journal, 2023
Mitogen-activated protein kinase (MEK) inhibitors and oncolytic virotherapy are identified as promising cancer therapies that can enhance the efficacy of other cancer treatments.
M. Moksud Alam, S.M.E.K. Chowdhury, J.T. Chowdhury, Mohammad Mahmud Hasan, M.A. Ullah, Shams Forruque Ahmed   +5 more
doaj   +1 more source

Targeting tumor vasculature through oncolytic virotherapy: recent advances

, 2015
The oncolytic virotherapy field has made significant advances in the last decade, with a rapidly increasing number of early- and late-stage clinical trials, some of them showing safety and promising therapeutic efficacy.
Merchan, Jaime R, Toro Bejarano, Marcela   +1 more
core   +1 more source