Results 61 to 70 of about 10,988 (206)

Chaotic behavior in virotherapy for cancer treatment

, 2017
This paper studies chaotic behavior in cancer dynamics when a treatment procedure is introduced. Recently introduced virotherapy is considered for the cancer treatment.
Metin U. Salamci, Soufiani, Babak Naseri, Babak Naseri Soufiani, SALAMCİ, METİN UYMAZ   +3 more
core   +1 more source

High Level Production of Monoclonal Antibodies Using an Optimized Plant Expression System

Frontiers in Bioengineering and Biotechnology, 2020
Biopharmaceuticals are a large and fast-growing sector of the total pharmaceutical market with antibody-based therapeutics accounting for over 100 billion USD in sales yearly.
Andrew G. Diamos, Andrew G. Diamos, Joseph G. L. Hunter, Joseph G. L. Hunter, Mary D. Pardhe, Mary D. Pardhe, Sun H. Rosenthal, Sun H. Rosenthal, Haiyan Sun, Haiyan Sun, Bonnie C. Foster, Michelle P. DiPalma, Michelle P. DiPalma, Qiang Chen, Qiang Chen, Hugh S. Mason, Hugh S. Mason   +16 more
doaj   +1 more source

High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe, Yasemin van Heuvel, Kathrina Scheiermann, Patrick Bongartz, Yvonne Genzel, Udo Reichl   +5 more
wiley   +1 more source

Targeting Gene-Virotherapy for Cancer [PDF]

Acta Biochimica et Biophysica Sinica, 2005
Gene therapy and viral therapy for cancer have therapeutic effects, but there has been no significant breakthrough in these two forms of therapy. Therefore, a new strategy called "targeting gene-virotherapy", which combines the advantages of gene therapy and viral therapy, has been formulated. This new therapy has stronger antitumor effects than either
Xin-Yuan, Liu, Jing-Fa, Gu, Wen-Fang, Shi   +2 more
openaire   +2 more sources

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Virotherapy – cancer targeted pharmacology

Drug Discovery Today, 2012
Building on their success in vaccination, many groups are now exploring the use of viruses as anticancer agents. In general, viral therapeutics provide the possibility to express anticancer proteins directly at the tumour site, decreasing exposure to normal tissue during delivery and maximising therapeutic index.
Tedcastle, A, Cawood, R, Di, Y, Fisher, K, Seymour, L   +4 more
openaire   +3 more sources

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Oncolytic polio virotherapy of cancer [PDF]

Cancer, 2014
Recently, the century‐old idea of targeting cancer with viruses (oncolytic viruses) has come of age, and promise has been documented in early stage and several late‐stage clinical trials in a variety of cancers. Although originally prized for their direct tumor cytotoxicity (oncolytic virotherapy), recently, the proinflammatory and immunogenic effects ...
Michael C, Brown, Elena Y, Dobrikova, Mikhail I, Dobrikov, Ross W, Walton, Sarah L, Gemberling, Smita K, Nair, Annick, Desjardins, John H, Sampson, Henry S, Friedman, Allan H, Friedman, Douglas S, Tyler, Darell D, Bigner, Matthias, Gromeier   +12 more
openaire   +2 more sources

Intratumoral Administration of Recombinant Murine Interleukin‐12 Prevents Tumor Progression and Bone Invasion

Oral Diseases, EarlyView.
ABSTRACT Objective Oral squamous cell carcinoma (OSCC) frequently invades the mandibular bone, leading to metastasis and poor prognosis. This study aimed to evaluate the therapeutic effects of locally administered interleukin‐12 (IL‐12) using an immunocompetent mouse model mimicking the clinical features of mandibular bone invasion. Methods The effects
Shun Kasahara, Miki Kashiwagi, Toshihiro Inubushi, Akinari Sugauchi, Wu Deyong, Kyoko Kurioka, Kazuaki Miyagawa, Takuma Matsuda, Soju Seki, Mikihiko Kogo, Susumu Tanaka, Toshihiro Uchihashi   +11 more
wiley   +1 more source

Implications of MicroRNAs in Oncolytic Virotherapy [PDF]

Frontiers in Oncology, 2017
MicroRNAs (miRNAs) are an abundant class of small non-coding RNA molecules (~22 nt) that can repress gene expression. Deregulation of certain miRNAs is widely recognized as a robust biomarker for many neoplasms, as well as an important player in tumorigenesis and the establishment of tumoral microenvironments.
Xavier Bofill-De Ros, Xavier Bofill-De Ros, Maria Rovira-Rigau, Maria Rovira-Rigau, Cristina Fillat, Cristina Fillat   +5 more
openaire   +3 more sources