Results 51 to 60 of about 11,703 (213)
Frontiers in Oncology, 2018 Melanoma is considered an aggressive malignancy with a tendency of forming metastasis in the brain. Less than 10% of all melanoma cases present with unknown primary tumor location.
Guna Proboka +5 more
doaj +1 more source
Current Status and Challenges of Oncolytic Virotherapy for the Treatment of Glioblastoma
Pharmaceuticals, 2023 Despite decades of research and numerous clinical trials, the prognosis of patients diagnosed with glioblastoma (GBM) remains dire with median observed survival at 8 months.
M. Webb, U. Sener, R. Vile
semanticscholar +1 more source
Alexandria Engineering Journal, 2023 Mitogen-activated protein kinase (MEK) inhibitors and oncolytic virotherapy are identified as promising cancer therapies that can enhance the efficacy of other cancer treatments.
M. Moksud Alam +5 more
doaj +1 more source
Opportunities and challenges of combining adoptive cellular therapy with oncolytic virotherapy
Molecular Therapy: Oncolytics, 2023 The use of oncolytic viruses (OVs) and adoptive cell therapies (ACT) have independently emerged as promising approaches for cancer immunotherapy. More recently, the combination of such agents to obtain a synergistic anticancer effect has gained attention,
Joseph. Mamola +5 more
semanticscholar +1 more source
VirusesNUT carcinoma (NC) is a rare exceptionally aggressive malignancy, defined by NUTM1 gene translocations, most commonly generating a BRD4::NUTM1 fusion that results in a poor prognosis and limited therapeutic options. Oncolytic virotherapy has emerged as a
Fiona D. Nitschke +6 more
doaj +1 more source
Modeling dynamics of cancer virotherapy with immune response
Advances in Difference Equations, 2020 Virotherapy is a therapeutic treatment for cancer. It uses genetically engineered viruses to selectively infect, replicate in, and destroy cancer cells without damaging normal cells.
Salma M. Al-Tuwairqi +2 more
doaj +1 more source
Immunosuppressive cells in oncolytic virotherapy for glioma: challenges and solutions
Frontiers in Cellular and Infection Microbiology, 2023 Glioblastoma is a highly aggressive form of brain cancer characterized by the abundance of myeloid lineage cells in the tumor microenvironment. Tumor-associated macrophages and microglia (TAM) and myeloid-derived suppressor cells (MDSCs), play a pivotal ...
Junfeng Liu +5 more
semanticscholar +1 more source
Personalizing Oncolytic Virotherapy?
Molecular Therapy, 2007 raditionally, cancer therapies have been based on the empiric discovery of drugs and/or biological agents that act selectively against tumor cells. Recently, however, a generation of rationally discov-ered drugs and agents has been developed that shows encouraging benefi t in treating cancers.
Kaur, Balveen, Chiocca, E Antonio
openaire +2 more sources
Gene and virotherapy for hematological malignancies [PDF]
International Journal of Hematology, 2016 Recent years have seen a transformation in the treatment of hematological malignancies. Advances in gene therapy and molecular techniques and significant gains in computational abilities have supported the rapid development of safer and better tolerated therapies for many patients with hematologic cancers.
Evidio, Domingo-Musibay +1 more
openaire +2 more sources
VirusesNUT (nuclear-protein-in-testis) carcinoma (NC) is a highly aggressive tumor disease. Given that current treatment regimens offer a median survival of six months only, it is likely that this type of tumor requires an extended multimodal treatment approach
Stavros Sotiriadis +5 more
doaj +1 more source