Results 121 to 130 of about 16,654 (161)

Oncolytic Viruses

Investigational New Drugs, 1999
Viruses capable of inducing lysis of malignant cells through their replication process are known as "oncolytic" viruses. Clinical trials in oncology have been performed with oncolytic viruses for nearly fifty years. Both systemic and intratumoral routes of administration have been explored.
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Progress of oncolytic viruses in sarcomas

Expert Review of Anticancer Therapy, 2012
Oncolytic virotherapy has shown exciting promise for the treatment of many types of solid tumors. Pediatric sarcomas are an aggressive type of pediatric malignancy known to show limited responsiveness to current therapies, leading to unacceptably high morbidity and mortality.
Christina K, Lettieri, Pooja, Hingorani, E Anders, Kolb   +2 more
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Oncolytic viruses in radiation oncology

Radiotherapy and Oncology, 2011
Oncolytic viruses are investigational cancer treatments. They are currently being assessed as single agents or in combination with standard therapies such as external beam radiotherapy - a DNA damaging agent that is a standard of care for many tumour types.
Yann, Touchefeu, Georges, Vassaux, Kevin J, Harrington   +2 more
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Oncolytic viruses and cancer therapy

Cytokine & Growth Factor Reviews, 2001
In the hopes that a better understanding of cancer biology would allow for the development of novel, more effective therapeutics, a concerted effort over the past 20 years has focussed on the molecular mechanisms of cell growth control and tumorigenesis.
K L, Norman, F, Farassati, P W, Lee
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Oncolytic viruses in the therapy of gliomas

Molecular Biology, 2012
Despite the advances of modern medicine, malignant glioblastoma cure remains an elusive goal. Both the invasive nature and location in vital areas of the brain make this type of tumors difficult for surgical treatment, while the current adjuvant therapy is not as successful as expected.
N V, Gubanova, A S, Gaĭtan, I A, Razumov, V A, Mordvinov, A L, Krivoshapkin, S V, Netesov, P M, Chumakov   +6 more
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Oncolytic viruses—immunotherapeutics on the rise

Journal of Molecular Medicine, 2016
The oncolytic virus (OV) field has entered an exciting period in its evolution in which our basic understanding of viral biology and anti-cancer potential are being actively translated into viable therapeutic options for aggressive malignancies. OVs are naturally occurring or engineered viruses that are able to exploit cancer-specific changes in ...
Brian A, Keller, John C, Bell
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Future Directions: Oncolytic Viruses

Clinical Lung Cancer, 2004
Oncolytic viruses offer a promising new modality for cancer treatment. The strategy of this therapy is to develop viruses capable of selectively infecting and replicating in malignant tumor cells. Oncolytic viruses can spread and destroy malignant tumors without deleterious effects in normal tissues.
Liang, You, Biao, He, Zhidong, Xu, Frank, McCormick, David M, Jablons   +4 more
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Macrophages and their interactions with oncolytic viruses

Current Opinion in Pharmacology, 2015
Macrophages are a highly plastic cell type and exhibit a range of defensive and regulatory functions in normal physiology. Phagocytic macrophages play an important role in defending against virus infection and they provide an important barrier that can limit the delivery of therapeutic viruses from the injection to the tumour.
Philip G, Jakeman, Thomas E, Hills, Kerry D, Fisher, Leonard W, Seymour   +3 more
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Recent Clinical Experience with Oncolytic Viruses

Current Pharmaceutical Biotechnology, 2012
There has been interest in using viruses to treat cancer for over a century. Recent clinical efforts, driven on by significant preclinical advances, have focussed on the safety of using replication-competent viruses. Recently published clinical trials of six oncolytic viruses (adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus and ...
Donnelly, OG, Errington-Mais, F, Prestwich, R, Harrington, K, Pandha, H, Vile, R, Melcher, AA   +6 more
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Oncolytic Viruses: Whats Next?

Current Cancer Drug Targets, 2007
Cancer is a complex disease that often eludes successful treatment due to its propensity to evolve or adapt in the face of current therapeutic regimes. It is reasonable to suggest that sophisticated therapeutics that can attack cancers in multiple, but targeted ways, will be necessary in order to improve current success rates.
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