Results 121 to 130 of about 1,862,769 (263)
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Cancer Science, EarlyView.Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe +5 more
wiley +1 more source
Integrated Engineering of CAR‐T Cells for Solid Tumours
Cell Proliferation, EarlyView.Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source
The impact of innate immune response on the efficacy of oncolytic viruses
Вопросы вирусологииOncolytic viruses represent a promising class of immunotherapeutic agents for the treatment of malignant tumors. The proposed mechanism of action of various oncolytic viruses has initially been explained by the ability of such viruses to selectively lyse
Kirill N. Trachuk +3 more
doaj +1 more source
Targeting Nucleotide Biosynthesis: A Strategy for Improving the Oncolytic Potential of DNA Viruses
Frontiers in Oncology, 2017 The rapid growth of tumors depends upon elevated levels of dNTPs, and while dNTP concentrations are tightly regulated in normal cells, this control is often lost in transformed cells.
Chad R. Irwin +5 more
doaj +1 more source
Translation of oncolytic viruses in sarcoma. [PDF]
Mol Ther OncolSarcomas are a rare and highly diverse group of malignancies of mesenchymal origin. While sarcomas are generally considered resistant to immunotherapy, recent studies indicate subtype-specific differences in clinical response to checkpoint inhibitors (CPIs) that are associated with distinct immune phenotypes present in sarcoma subtypes.
Robinson SI +3 more
europepmc +4 more sources
Oncolytic viruses: overcoming translational challenges
Journal of Clinical Investigation, 2019 Oncolytic virotherapy (OVT) is a promising approach in which WT or engineered viruses selectively replicate and destroy tumor cells while sparing normal ones.
Jordi Martínez-Quintanilla +3 more
semanticscholar +1 more source
Mechanisms of Therapeutic Resistance and Recent Advances in Glioblastoma Treatment
Immunology &Cell Biology, EarlyView.Three interconnected processes in glioblastoma (GBM) biology: initiation, stratification, and immunosuppression. 1) Initiation: GBM initiation is proposed to occur through migration of TERT mutation‐bearing neural stem cells from the subventricular zone to the frontal and temporal cortices, where a subsequent oncogenic transformation drives their ...
Emerson Achari +6 more
wiley +1 more source
Nanoparticle‐Mediated Therapy for Glioma: Advances and Prospects
MedComm – Oncology, Volume 5, Issue 3, September 2026.Various nanocarriers, including liposomes, dendrimers, exosomes and gold nanoparticles, are designed to penetrate the blood‐brain barrier and deliver chemotherapy, radiotherapy, immunotherapy, gene therapy, phototherapy, magnetic hyperthermia and sonodynamic therapy for glioma.
Wenqian Jiang +5 more
wiley +1 more source
The Effect of Oncolytic Viruses in Aiding Cancer Immunotherapy [PDF]
, 2021 Oncolytic viruses are known as genetically engineered viruses or ones that can be found in nature, that are used to selectively reproduce in cancer cells and kill them without harming the normal and healthy cells.
Singh, Anushka
core +1 more source