Results 81 to 90 of about 1,862,769 (263)
Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma
Advanced NanoBiomed Research, EarlyView.Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira +7 more
wiley +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
Oncolytic viruses: finally delivering [PDF]
British Journal of Cancer, 2016 Oncolytic viruses can be found at the confluence of virology, genetic engineering and pharmacology where versatile platforms for molecularly targeted anticancer agents can be designed and optimised. Oncolytic viruses offer several important advantages over traditional approaches, including the following.
Seymour, Leonard W, Fisher, Kerry D
openaire +2 more sources
Cell Death and Disease, 2020 Glioblastoma (GBM) is an immunosuppressive, lethal brain tumor. Despite advances in molecular understanding and therapies, the clinical benefits have remained limited, and the life expectancy of patients with GBM has only been extended to ~15 months ...
Qing Zhang, Fusheng Liu
semanticscholar +1 more source
High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor
Biotechnology and Bioengineering, EarlyView.ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe +5 more
wiley +1 more source
Assessment and development of adenovirus type 11 for cancer therapy [PDF]
, 2010 PhDThe efficacy of oncolytic virotherapy is influenced by the interactions between the tumour, virus and host immunity. The first generation of oncolytic adenoviruses, based on serotype 5 (Ad5), has achieved limited success in clinical trials.
Wong, Han Hsi
core
Harnessing the Power of Onco-Immunotherapy with Checkpoint Inhibitors
Viruses, 2015 Oncolytic viruses represent a diverse class of replication competent viruses that curtail tumor growth. These viruses, through their natural ability or through genetic modifications, can selectively replicate within tumor cells and induce cell death ...
Karishma R. Rajani, Richard G. Vile
doaj +1 more source
Status and future of recombinant adeno‐associated virus vector manufacturing
Biotechnology Progress, EarlyView.Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley +1 more source
Oncolytic adenovirus dl922-947 targets the DNA damage signaling pathway and enhances the effects of radiation therapy [PDF]
, 2011 Replication selective oncolytic viruses (OVs) are a rapidly expanding therapeutic platform for cancer treatment. OVs are characterized by genetic alterations that ablate critical viral protein functions essential for viral replication in normal cells ...
Abagnale, Antonella
core
Fighting cancer with oncolytic viruses [PDF]
BMJ, 2006 Although gene therapy has huge potential for modern medicine, our enthusiasm for its powerful potential must not cloud our judgment about the dangers of using increasingly diverse, yet relatively untested, replicating ...
Yuti, Chernajovsky +2 more
openaire +2 more sources