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Personalizing Oncolytic Virotherapy
Human Gene Therapy, 2023The use of oncolytic viruses has become an attractive tool in the clinics for the treatment of various tumor types. Such viruses are genetically modified to conditionally replicate in malignant cells while unharming healthy cells. This platform offers a highly specific tumor killing with exceptional safety profiles.
Firas Hamdan +2 more
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What is oncolytic virotherapy? [PDF]
Archives of disease in childhood - Education & practice edition, 2017 It has long been hypothesised that viruses may have a role in treating cancer. From the mid-1800s, there has been documentation of patients undergoing spontaneous cancer remission following severe infection, and by the start of the 20th century, a temporary complete remission of acute leukaemia was observed in a patient suffering from influenza.1 Over ...
Julia V. Cockle, Karen Scott
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Oncolytic virotherapy as immunotherapy
Science, 2021Recognizing immune responses to oncolytic virotherapy opens the way for new ...
Alan, Melcher +2 more
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Journal of Vascular and Interventional Radiology, 2013
Oncolytic virotherapy is an emerging technology that uses engineered viruses to treat malignancies. Viruses can be designed with biological specificity to infect cancerous cells preferentially, and to replicate in these cells exclusively. Malignant cells may be killed directly by overwhelming viral infection and lysis, which releases additional viral ...
Steven C. Rose +2 more
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Oncolytic virotherapy is an emerging technology that uses engineered viruses to treat malignancies. Viruses can be designed with biological specificity to infect cancerous cells preferentially, and to replicate in these cells exclusively. Malignant cells may be killed directly by overwhelming viral infection and lysis, which releases additional viral ...
Steven C. Rose +2 more
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Poxvirus oncolytic virotherapy
Expert Opinion on Biological Therapy, 2019Over the last decade, advances in biological therapies have resulted in remarkable clinical responses for the treatment of some previously incurable cancers. Oncolytic virotherapy is one of these promising novel strategies for cancer therapy. A successful oncolytic virus promotes tumor cell oncolysis and elicits a robust long-term anti-tumor immunity ...
Lino E. Torres-Dominguez, Grant McFadden
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Oncolytic virotherapy: Challenges and solutions
Current Problems in Cancer, 2021Viruses as cancer therapies have attracted attention since the 19th century. Scientists observation that viruses can preferentially lyse cancer cells rather than healthy cells, created the field of oncolytic virology. Like other therapeutic strategies, oncolytic virotherapy has challenges, such as penetration into tumor bulk, anti-viral immune ...
Nasser Hashemi Goradel +5 more
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2018
Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type and non-engineered in vitro-passaged virus strains and vaccine strains (first generation oncolytic viruses ...
Fumi Goshima, Daisuke Watanabe
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Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type and non-engineered in vitro-passaged virus strains and vaccine strains (first generation oncolytic viruses ...
Fumi Goshima, Daisuke Watanabe
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Oncolytic virotherapies for pediatric tumors
Expert Opinion on Biological Therapy, 2023Many pediatric patients with malignant tumors continue to suffer poor outcomes. The current standard of care includes maximum safe surgical resection followed by chemotherapy and radiation which may be associated with considerable long-term morbidity.
Evan G Gross +6 more
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Introduction to Oncolytic Virotherapy
2019Oncolytic viruses exploit key hallmarks of cancer for replication in malignant cells, leading to tumor cell lysis, modulation of the tumor microenvironment and in situ vaccination effects. Diverse virus platforms have been developed as oncolytic vectors and designed for improved tumor specificity, intratumoral spread, therapeutic gene delivery and ...
John C. Bell +2 more
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Oncolytic virotherapy for multiple myeloma
Expert Opinion on Biological Therapy, 2008Current therapies for multiple myeloma (MM) are not curative, thus novel targeted therapeutics are being developed. One such targeted therapy is oncolytic virotherapy, wherein viruses specifically infect and kill the malignant plasma cells, leaving normal cells intact.This review provides an overview of the mechanisms and results of the oncolytic ...
Amaalia E Stief, J. Andrea McCart
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