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Oncolytic virotherapy reaches adolescence
Pediatric Blood & Cancer, 2010AbstractLytic viruses kill cells as a consequence of their normal replication life cycle. The idea of harnessing viruses to kill cancer cells arose over a century ago, before viruses were even discovered, from medical case reports of infections associated with cancer remissions.
Adrienne M. Hammill +2 more
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Oncolytic virotherapy in lung cancer
2023Lung tumors are one of the most aggressive threats affecting humans. Current therapeutic approaches have improved patients' survival; however, further efforts are required to increase effectiveness and protection against tumor relapse and metastasis. Immunotherapy presents an alternative to previous treatments that focuses on stimulating of the patient'
Estanislao, Nistal-Villan +2 more
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Oncolytic virotherapy of gynecologic malignancies
Gynecologic Oncology, 2011Gynecologic cancer is still the third leading cause of cancer death among women in the US. Therapeutics employing novel mechanisms of action are therefore urgently needed. Oncolytic viruses (OVs) selectively infecting and replicating in cancer cells have recently attracted considerable interest as promising anti-cancer agents.
Tanja Fehm +3 more
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Oncolytic virotherapy for urological cancers
Nature Reviews Urology, 2016Oncolytic virotherapy is a cancer treatment in which replication-competent viruses are used that specifically infect, replicate in and lyse malignant tumour cells, while minimizing harm to normal cells. Anecdotal evidence of the effectiveness of this strategy has existed since the late nineteenth century, but advances and innovations in ...
Kaixin Zhang +3 more
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Recent Patents in Oncolytic Virotherapy
Recent Patents on Biotechnology, 2016Recent innovative and advanced developments in the diagnosis and treatment of human diseases as well as enhanced in-depth understanding of virus molecular biology have opened novel avenues with respect to the patent landscape. Included are viruses utilized in the development of anticancer agents, agents that are employed against the spread of ...
Kathleen Hefferon +3 more
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Mathematical Modeling of Oncolytic Virotherapy
2019Mathematical modeling in biology has a long history as it allows the analysis and simulation of complex dynamic biological systems at little cost. A mathematical model trained on experimental or clinical data can be used to generate and evaluate hypotheses, to ask "what if" questions, and to perform in silico experiments to guide future experimentation
Johannes P W Heidbuechel +4 more
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Oncolytic Virotherapy of Cancer
2010It has been almost two decades since the first genetically engineered oncolytic virus was reported in 1991. Since then, many novel strategies have been developed to further improve oncolytic virus tumor selectivity and antitumoral potency, which are the two most important factors that would eventually determine the clinical safety and efficacy of any ...
Aladar A. Szalay +3 more
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Oncolytic virotherapy of breast cancer
Gynecologic Oncology, 2011The use of replication competent viruses that selectively target and destroy cancer cells has rapidly evolved over the past decade and numerous innovative oncolytic viruses have been created. Many of these promising anti-cancer agents have recently entered into clinical trials (including those on breast cancer) and demonstrated encouraging safety and ...
Tanja Fehm +3 more
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Oncolytic Virotherapy and the Tumor Microenvironment
2017Oncolytic viral therapy is a promising approach to treat many malignancies, including breast, colorectal, hepatocellular, and melanoma. The best results are seen when using "targeted and armed" viruses. These are viruses that have been genetically modified to selectively replicate within cancer cells and express specific transgenes that alter the tumor
Steve H. Thorne +2 more
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Immunomodulation in Oncolytic Measles Virotherapy
2019With the recognition of oncolytic virotherapy as an immunotherapy, the distinct interactions between oncolytic agents and the immune system have come into focus. The role of the immune system in oncolytic virotherapy is somewhat ambiguous: While preexisting or arising immunity directed against viral antigens may preclude efficient viral replication and
Christine E. Engeland, Laura Dietz
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