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Lymphomas and Oncolytic Virus Therapy
Clinical Lymphoma, 2003There are several well-documented cases in medical literature of the remission of leukemias and malignant lymphomas following natural human viral infections. In the hope of being able to reproduce these spontaneous tumor regressions, investigators have studied various viruses with distinct oncolytic properties. The first attempts to treat patients with
Tommy, Alain +6 more
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Virus, Oncolytic Virus and Human Prostate Cancer
Current Cancer Drug Targets, 2017Prostate cancer (PCa), a disease, is characterized by abnormal cell growth in the prostate - a gland in the male reproductive system. Although older age and a family history of the disease have been recognized as the risk factors of PCa, the cause of this cancer remains unclear.
Liu, Guang Bin +3 more
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Oscillations in a Spatial Oncolytic Virus Model
Bulletin of Mathematical Biology, 2023AbstractVirotherapy treatment is a new and promising target therapy that selectively attacks cancer cells without harming normal cells. Mathematical models of oncolytic viruses have shown predator-prey like oscillatory patterns as result of an underlying Hopf bifurcation.
Arwa Abdulla Baabdulla, Thomas Hillen
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Regulatory Aspects of Oncolytic Virus Products
Current Cancer Drug Targets, 2007Many types of oncolytic viruses, wild-type virus, attenuated viruses and genetically-modified viruses, have been developed as an innovative cancer therapy. The strategies, nature, and technologies of oncolytic virus products are different from the conventional gene therapy products or cancer therapy products.
Teruhide, Yamaguchi, Eriko, Uchida
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Oncolytic Herpes Virus Shrinks Pediatric Gliomas
Cancer Discovery, 2021Abstract In a small trial involving children with progressive high-grade gliomas, direct infusions of a genetically engineered strain of herpes simplex virus elicited responses in 11 of 12 recipients. The therapy also led to more than a doubling in average patient survival compared with historical expectations.
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Journal of Biomedical Nanotechnology
Oncolytic viruses have made tremendous advances in fundamental research and clinical trials in recent years as potential anti-cancer medications. Oncolytic viruses, which are either genetically modified or naturally occurring, can kill cancer cells without harming healthy cells.
Chen Wu +3 more
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Oncolytic viruses have made tremendous advances in fundamental research and clinical trials in recent years as potential anti-cancer medications. Oncolytic viruses, which are either genetically modified or naturally occurring, can kill cancer cells without harming healthy cells.
Chen Wu +3 more
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Oncolytic virus therapy for prostate cancer
International Journal of Urology, 2009AbstractThe use of replication‐competent viruses that can selectively replicate in and destroy neoplastic cells is an attractive strategy for treating cancer. Various oncolytic viruses have been taken to clinical trials since a recombinant virus was first applied to cancer patients a decade ago.
Hiroshi, Fukuhara +2 more
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Spatial Oncolytic Virus Dynamics
2013Tumors are often characterized by intricate spatial structures. Therefore, understanding the principles of virus spread in spatially structured tumor cell populations is of fundamental importance. This chapter describes a two-dimensional spatial model where cells and viruses can place their offspring only into the direct vicinity. This describes a cell
Natalia L. Komarova, Dominik Wodarz
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Measles as a potential oncolytic virus
Reviews in Medical Virology, 2005The use of replicating viruses for cancer therapy is attracting increasing interest. Numerous viruses are now being considered as potential cancer therapeutics, including the vaccine strain of measles virus (MV). The attenuated strain of measles readily lyses transformed cells, whilst replication and lysis are limited in normal human cells.
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Cancer gene and oncolytic virus therapy
Seminars in Oncology, 2001By far, cancer accounts for the majority of gene therapy trials that are being carried out worldwide. Seventy percent of the gene therapy protocols that have been reviewed by the National Institutes of Health Recombinant DNA Advisory Committee (NIH RAC) are for the treatment of cancer.
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