Results 21 to 30 of about 43,993 (273)

A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea [PDF]

, 2013
Background: Irritable bowel syndrome with diarrhoea (IBS-D) is particularly debilitating due to urgency and episodic incontinence. Some 5-hydroxytryptamine 3 (5-HT3) receptor antagonists (5-HT3RAs) have proven effective but have serious side effects ...
Amanda Henry, Andresen, Brown, Camilleri, Chang, Chang, Ching Lam, Clayton, Cremonini, Cremonini, Dunlop, Dunlop, Faure, Foley, Francis, Gershon, Gulzar Singh, Hahn, Heaton, Hirata, Ian Hall, Julia Chernova, Keating, Klara Garsed, Kozlowski, Krause, Kroenke, Levenstein, Longstreth, Luca Marciani, Marciani, Margaret Hastings, Matsueda, Matsueda, Maxton, Metcalf, Olden, Peter Whorwell, Robin Spiller, Spiegel, Spiegel, Spiller, Spiller, Talley, Tillisch, von der Ohe, Wiklund, Wolf, Zhu   +48 more
core   +2 more sources

Magnesium sulphate in the treatment of acute asthma: evaluation of current practice in adult emergency departments [PDF]

, 2009
Background: A recent meta-analysis showed that intravenous and nebulised magnesium sulphate have similar levels of evidence to support their use in the treatment of acute asthma in adults. This consisted of weak evidence of effect on respiratory function
Goodacre, S., Jones, L.A.
core   +1 more source

Minimal effective weight-based dosing of ondansetron to reduce hypotension in cesarean section under spinal anesthesia: a randomized controlled superiority trial

BMC Anesthesiology, 2018
BackgroundThe weight-based dosing of ondansetron to reduce hypotension has never been investigated. The aim of this study is to determine the optimal dose of ondansetron required based on the patient’s weight to reduce hypotension following spinal ...
M. Oofuvong, Thitikan Kunapaisal, Orarat Karnjanawanichkul, Nussara Dilokrattanaphijit, Jaranya Leeratiwong   +4 more
semanticscholar   +1 more source

Ondansetron Exposure Changes in a Pregnant Woman [PDF]

, 2016
Pregnancy results in many physiologic changes that can alter the pharmacokinetic profiles of medications used during pregnancy. One of the primary factors leading to these pharmacokinetic changes is altered activity of drug-metabolizing enzymes ...
Caritis, Steve N., Haas, David M., Hankins, Gary D., Hebert, Mary F., Lemon, Lara S., Venkataramanan, Raman, Zhang, Hongfei   +6 more
core   +1 more source

The role of ondansetron in the management of cholestatic or uremic pruritis - a systematic review [PDF]

, 2012
Pruritus associated with hepatic or renal failure can be a troublesome symptom, refractory to treatment, associated with significant physical and emotional distress, and reduction in quality of life for patients already burdened with chronic disease ...
Clark, Katherine, Currow, David Christopher, Lam, Lawrence, Shelby-James, Tania Maree, To, Timothy H M   +4 more
core   +1 more source

Comparison of ondansetron with ondansetron and dexamethasone in prevention of PONV in diagnostic laparoscopy [PDF]

Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 1999
To compare the efficacy of ondansetron-dexamethasone combination with ondansetron alone for prevention of postoperative nausea and vomiting (PONV).This double blind, randomized study was carried out in 51 female patients, aged 20-40 yr, ASA-1 physical status undergoing gynecological diagnostic laparoscopy. Group 1 (n = 26) received 4 mg ondansetron i.v.
Yatindra Kumar Batra, V. Rajeeva, L. K. Dhaliwal, Neerja Bhardwaj   +3 more
openaire   +2 more sources

Efficacy of Ondansetron in the Prevention or Treatment of Post-operative Delirium—a Systematic Review

Canadian Geriatrics Journal, 2019
Background Post-operative delirium (POD) is associated with higher rates of functional decline and death. Ondansetron is a serotonin antagonist which could represent a therapeutic or preventive option in POD.
Nihal Haque, R. Naqvi, M. Dasgupta
semanticscholar   +1 more source

Postoperative pain management in children: Guidance from the pain committee of the European Society for Paediatric Anaesthesiology (ESPA Pain Management Ladder Initiative) [PDF]

, 2018
The main remit of the European Society for Paediatric Anaesthesiology (ESPA) Pain Committee is to improve the quality of pain management in children. The ESPA Pain Management Ladder is a clinical practice advisory based upon expert consensus to help to ...
Adamek, Akin, Al-Zaben, Alm, Amminnikutty, Amoli, Anderson, Anderson, Antila, Arcioni, Association of Paediatric Anaesthetists of Great Britain and Ireland, Aubrun, Aveline, Aysenur, Bailey, Bailie, Bakan, Baley, Becke, Beers, Bell, Ben-Meir, Bertini, Bhalla, Birmingham, Bouwmeester, Bozkurt, Breitfeld, Breschan, Breschan, Brown, Brown, Büttner, Carstensen, Cha, Chan, Chou, Conti, Cousins, Crellin, Cyna, Dadure, Dadure, Dahi-Taleghani, Dahmani, Dalens, Das, Derry, Derry, Duedahl, Ecoffey, El-Fattah, Elshammaa, Fendrich, Fieler, Finkel, Flack, Fösel, Ganidagli, Gear, Gemma, Ginsberg, Glover, Habre, He, Hicks, Hinz, Holmer Pettersson, Hong, Howard, Hudcova, Huenseler, Huynh, Höhne, Ingelmo, Ivani, Ivani, Ivani, Ivani, Jahr, Jaksch, José María, Ju, Jöhr, Kamata, Kart, Kimiaei Asadi, Kokki, Kokki, Kokki, Kokki, Koppert, Kost-Byerly, Kost-Byerly, Kubica-Cielińska, Kumar, Kurihara, Kwak, Lam, Laskowski, Lavonas, Leclair, Lee, Leksowski, Leoni, Litalien, Liu, Liu, Lorenzo, Lundeberg, Lönnqvist, Lönnqvist, Lönnqvist, Manworren, Marel, Marhofer, Mazoit, McNicol, Merry, Messerer, Messerer, Miller, Miró, Mobley, Mohammed, Momeni, Moriceau, Morton, Morton, Mukherjee, Müller, Mędrzycka-Dąbrowska, O'Sullivan, Olkkola, Orange, Ousley, Pace, Park, Park, Pasero, Petrat, Pierce, Polaner, Qian, Rabbitts, Redmann, Richer, Rugyte, Sahin, Sammartino, Sandeman, Schnabel, Schnabel, Schug, Schug, Schug, Schultz-Machata, Sekhavat, She, Shirazi, Sng, Soh, Sola, Soulard, Southworth, Sowder, Spacek, Splinter, Stamer, Staschen, Steans, Steffen, Subramanyam, Suresh, Taheri, Tobias, Tsuchiya, Valizadeh, Voepel-Lewis, Walker, Walther-Larsen, Walther-Larsen, Wang, Weintraud, Willschke, Willschke, Willschke, Wilson, Wilson-Smith, Wininger, Wong, Wong, Xue, Xue, Yaster, Yildiz, Yung   +196 more
core   +1 more source

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

Ondansetron in Multiple Sclerosis [PDF]

Journal of Pain and Symptom Management, 2000
Two young women with chronic nausea and vertigo caused by multiple sclerosis responded to the introduction and maintenance of the 5HT3 receptor antagonist, ondansetron. Palliative care is a neglected aspect of management of degenerative neurological diseases and these cases highlight the approaches that may be used to manage difficult symptoms in the ...
openaire   +3 more sources