Results 81 to 90 of about 29,325 (273)

Opportunities and Challenges of Population Pharmacogenomics

Annals of Human Genetics, EarlyView.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou, Yoomi Park, Mahamadou D. Camara, Volker M. Lauschke   +3 more
wiley   +1 more source

Evaluating the impact of general practice pharmacist‐led person‐centred medicines reviews on medicines appropriateness and patient‐reported outcome measures

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this study was to investigate the impact of pharmacist‐led person‐centred medicines reviews in general practices on medicines appropriateness, polypharmacy indicators (high‐risk prescribing markers), and patient‐reported outcome measures (PROMs).
Clare Kinahan, Ciara Kirke, Leon O'Hagan, Frank Moriarty, Kevin D. Murphy, Laura J. Sahm, Cian O'Mahony, Emma J. Coyle, Stephen Byrne, Kieran Dalton   +9 more
wiley   +1 more source

When, which and how to switch: Navigating JAK inhibitors in myelofibrosis

British Journal of Haematology, EarlyView.
Navigating choice of JAK inhibitor (JAKi) therapy for patients with myelofibrosis who are JAKi‐naïve and for those who have previously been treated with a JAKi.
Jennifer O'Sullivan, Imran Omerdeen, Bethan Psaila   +2 more
wiley   +1 more source

Comparison of ramosetron and ondansetron for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a meta-analysis of randomized controlled trials

Journal of International Medical Research, 2019
Objective We conducted a systematic literature search and meta-analysis to identify randomized controlled trials (RCTs) comparing the efficacy and safety of ramosetron versus ondansetron for the prevention of postoperative nausea and vomiting (PONV; PON ...
Yiping Li, Ruiming Deng, Juan Zhou, Yuan Chen, Aiping Ouyang   +4 more
doaj   +1 more source

Oral Ondansetron versus Domperidone for Acute Gastroenteritis in Pediatric Emergency Departments: Multicenter Double Blind Randomized Controlled Trial

PLoS ONE, 2016
The use of antiemetics for vomiting in acute gastroenteritis in children is still a matter of debate. We conducted a double-blind randomized trial to evaluate whether a single oral dose of ondansetron vs domperidone or placebo improves outcomes in ...
F. Marchetti, M. Bonati, A. Maestro, D. Zanon, F. Rovere, A. Arrighini, E. Barbi, P. Bertolani, P. Biban, L. Da Dalt, A. Guala, E. Mazzoni, A. Pazzaglia, Paolo Francesco Perri, A. Reale, S. Renna, A. Urbino, E. Valletta, A. Vitale, T. Zangardi, A. Clavenna, L. Ronfani   +21 more
semanticscholar   +1 more source

Approach to the Management of Gastrointestinal Manifestations in Patients With Phaeochromocytoma and Paraganglioma

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Managing gastrointestinal symptoms in patients with phaeochromocytoma and paraganglioma (PPGL) is challenging due to the risk of catecholaminergic crisis with many commonly prescribed medications, especially in functional tumours.
Monica Majumder, Cherie Chiang, Grace Kong, Michael Michael, Nirupa Sachithanandan, Emma Boehm   +5 more
wiley   +1 more source

Comparative study between nalbuphine and ondansetron in prevention of intrathecal morphine-induced pruritus in women undergoing cesarean section

Anesthesia Essays and Researches, 2016
Background: Intrathecal morphine provides effective postoperative analgesia, but their use is associated with numerous side effects, including pruritus, nausea, vomiting, urinary retention, and respiratory depression.
Ahmed A. Moustafa, Amr Samir Baaror, Ibrahim Anwar Abdelazim   +2 more
semanticscholar   +1 more source

Outcomes of Melflufen Treatment in Patients With Relapsed/Refractory Multiple Myeloma

European Journal of Haematology, EarlyView.
ABSTRACT Objective Melphalan flufenamide (melflufen) plus dexamethasone is fully approved in Europe for patients with relapsed/refractory multiple myeloma (RRMM) with ≥ 3 prior lines of therapy. We analyzed the efficacy and safety of melflufen in the real‐world setting.
Shahrier Hossain, Clifton Mo, Sarah Patches, Houry Leblebjian, Kathryn Goodrich, Eileen Regan, Kathleen O'Neill, Kim Noonan, Paul G. Richardson, Jacob Laubach   +9 more
wiley   +1 more source

Effect of Ondansetron on Metformin Pharmacokinetics and Response in Healthy Subjects

Drug Metabolism And Disposition, 2016
The 5-hydroxytryptamine-3 (5-HT3) receptor antagonists such as ondansetron have been used to prevent and treat nausea and vomiting for over 2 decades. This study was to determine whether ondansetron could serve as a perpetrator drug causing transporter ...
Qing Li, Hong Yang, Dong Guo, Taolan Zhang, J. Polli, Honghao Zhou, Yan Shu   +6 more
semanticscholar   +1 more source

Ratifying the efficacy and safety of intensive induction chemotherapy for acute myeloid leukaemia by the Australasian Leukaemia & Lymphoma Group consensus approach

Internal Medicine Journal, EarlyView.
Abstract Background After pharmaceutical benefits scheme approval of midostaurin for fms‐like tyrosine kinase 3 (FLT3)‐mutated acute myeloid leukaemia (AML) in 2018, the Australasian Leukaemia & Lymphoma Group (ALLG) proposed a consensus approach to AML induction with 7+3 chemotherapy (7 days of infusional cytarabine with three doses of anthracycline ...
Aditya Tedjaseputra, Amanda Tey, Anastasios Nalpantidis, George Grigoriadis, Shaun Fleming, Shahla Vilcassim, Pasquale L. Fedele, Michael Sze Yuan Low, Paul Yeh, Michael Gilbertson, Ashwini Bennett, Gareth P. Gregory, Danielle Oh, Donna Gairns, Zane Kaplan, Sanjeev D. Chunilal, Susan Brown, Stephen Opat, Chong C. Chua, Jake Shortt   +19 more
wiley   +1 more source