The Comparison Effect of Preoperative Ondansetron and Metoclopramide in Reducing Nausea and Vomitting after Loparoscopic Cholecystectomy [PDF]
Background & Objectives: Postoperative nausea and vomiting (PONV) is one of the most common complications of anesthesia and without prophylactic intervention occurs in about one-third of patients under general anesthesia.
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Bioavailability of Oral Ondansetron in Dogs: A Crossover Study
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT The purpose of this study was to evaluate the pharmacokinetics of oral (PO) ondansetron compared to intravenous (IV) ondansetron in eight healthy client‐owned dogs. Dogs were randomized to one of two protocols in a crossover design, receiving PO or IV ondansetron at a dose of 1 mg/kg on Day 0 and the opposite formulation at an equal dose on ...
Amanda Garrick +5 more
wiley +1 more source
Neurogastroenterology &Motility, EarlyView.Anesthesia can alter measurements during digestive endoscopies, yet no standardized protocol currently exists. Two expert groups—the French Neuro‐Gastroenterology Group (GFNG) and anesthesiologists—used the Delphi method to reach a consensus on which drugs have an influence (91 amendments), ultimately resulting in a proposed anesthesia protocol (28 ...
Domitille Renard +29 more
wiley +1 more source
The comparison effect of ondansetron and Metoclopramide in thereducing of nausea and vomitting after loparoscopic cholescistectomy [PDF]
Background: Postoperative nausea and vomiting (PONV) is a side effect of anesthesia. Without prophylactic intervention, PONV by about one-third of patients (10 to 60%) under general anesthesia occurs. PONV consequences include delayed discharge from PACU
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Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer. [PDF]
, 2019 In preclinical studies, selenite had single agent activity and radiosensitized tumors in vivo. Here we report results from a Phase 1 trial in 15 patients with metastatic cancer treated with selenite (5.5 to 49.5 mg) orally as a single dose 2 hours before
Buyyounouski, Mark K +9 more
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Evaluation of person-level heterogeneity of treatment effects in published multiperson N-of-1 studies: systematic review and reanalysis. [PDF]
, 2018 OBJECTIVE:Individual patients with the same condition may respond differently to similar treatments. Our aim is to summarise the reporting of person-level heterogeneity of treatment effects (HTE) in multiperson N-of-1 studies and to examine the evidence ...
Balk, Ethan M +8 more
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Phase 1 Dose Escalation of Single‐Agent Mechlorethamine in Dogs With Lymphoma
Veterinary and Comparative Oncology, EarlyView.ABSTRACT Mechlorethamine is commonly prescribed to dogs at 3 mg/m2. The minimal toxicity observed indicates that higher doses of mechlorethamine are likely tolerable. The primary objective of this study was to determine the maximally tolerated dose (MTD) of mechlorethamine in dogs with lymphoma.
Laura E. Chadsey +2 more
wiley +1 more source
Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP) [PDF]
, 2013 BACKGROUND: Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued effectively unchanged.
A Markham +29 more
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Acta Anaesthesiologica Scandinavica, Volume 70, Issue 1, January 2026.ABSTRACT Introduction This study investigates the impact of active external warming on afterdrop in simulated accidental hypothermia, compared to the effect of passive warming measures. Methods This study used data from a randomized crossover field study of experimental hypothermia.
Sigurd Mydske +8 more
wiley +1 more source