Results 51 to 60 of about 30,790,443 (235)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

One-dimensional symmetry for semilinear equations with unbounded drift [PDF]

open access: yes, 2013
We consider semilinear equations with unbounded drift in the whole of Rn and we show that monotone solutions with nite energy are one ...
NOVAGA, MATTEO   +4 more
core   +1 more source

A DETR-based intelligent defect identification method for ultra-high-definition MFL detection of pipelines

open access: yesYou-qi chuyun
ObjectiveLong-distance oil and gas pipelines are critical components of global energy infrastructure. However, complex operating environments frequently induce surface defects that jeopardize structural integrity.
Shuyi WANG   +5 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Numerical Solution of linear drift-diffusion and pure drift equations on one-dimensional graphs [PDF]

open access: yes
We propose numerical schemes for the approximate solution of problems defined on the edges of a one-dimensional graph. In particular, we consider linear transport and a drift-diffusion equations, and discretize them by extending Finite Volume schemes ...
Villa, Andrea   +2 more
core   +1 more source

A 1D coupled Schrödinger drift-diffusion model including collisions [PDF]

open access: yes, 2004
We consider a one-dimensional coupled stationary Schroedinger drift-diffusion model for quantum semiconductor device simulations. The device domain is decomposed into a part with large quantum effects (quantum zone) and a part where quantum effects are ...
El Ayyadi, Asma   +3 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

Application of the Drift Flux Model to Multi-dimentional Multi-Phase Flow Analyses

open access: yes, 1997
The drift-flux model adopted in the present study basically treats the two phases as a homogeneous mixture while at the same time takes account of the relative movement between the phases with the concept of a multi-dimensional drift velocity.
福田, 研二   +11 more
core  

Online Learning of Entrainment Closures in a Hybrid Machine Learning Parameterization

open access: yesJournal of Advances in Modeling Earth Systems
This work integrates machine learning into an atmospheric parameterization to target uncertain mixing processes while maintaining interpretable, predictive, and well‐established physical equations.
Costa Christopoulos   +6 more
doaj   +1 more source

Assessment of flow with phase transition of geothermal fluids containing multi-component non-condensable gases and flash depth in medium-high temperature geothermal production wells

open access: yesMeitan xuebao
The flow with phase transition of geothermal fluids containing multi-component non-condensable gases in the wellbore is an important basis for evaluating the productivity, flash depth, and scale inhibition/removal of medium-to-high temperature geothermal
Hongwu Lei, Bing Bai
doaj   +1 more source

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