Results 111 to 120 of about 16,677,913 (308)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Diagnosis and surgical treatment of chronic destructive septic hip arthritis

Arthroplasty
Septic hip arthritis (SHA) is a relatively rare but hazardous disease. Much controversy exists regarding the definition, diagnosis and treatment of chronic destructive SHAs.
Zhishuo Zhang, Zida Huang, Xinyu Fang, Guochang Bai, Wenbo Li, Wenming Zhang, Chaofan Zhang   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

On the sample sizes of one-stage and two-stage sampling procedures under heteroscedasticity

, 2011
碩士在檢定母體平均數是否相等的變異數分析方法中，其基本假設是模型誤差項為獨立的常態分布、和有相等變異數。當變異數未知且不相等時，Bishop and Dudewicz (1978) 導出二階段抽樣程序方法，而 Chen (2001) 提出一階段抽樣程序方法，分別用來檢定是否有相同的母體平均數。本文首先討論一階段與二階段抽樣程序在同樣的總樣本數下，比較不同的起始樣本n0 的表現。此外在模型誤差項為不同分布時，討論兩種抽樣程序的型一誤差與檢定力表現。One of the assumptions of ...
蔡泳思; Tsai, Yung-Szu
core  

One-stage vs. two-stage bilateral total hip arthroplasty: no difference in clinical outcomes, complications and revision rates in at 5-year follow up

Frontiers in Surgery
Background/objectivesTotal hip arthroplasty (THA) is an effective treatment for end-stage hip disorders, improving pain, function, and quality of life. For bilateral hip disease, choosing between one-stage (simultaneous) and two-stage (staged) bilateral ...
Alessandra Monzio Compagnoni, Alice Montagna, Giada Accatino, Francesco Benazzo, Mario Mosconi, Mario Mosconi, Michela Saracco, Federico Alberto Grassi, Federico Alberto Grassi, Eugenio Jannelli, Eugenio Jannelli   +10 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

One-Stage-TFS: Thai One-Stage Fingerspelling Dataset for Fingerspelling Recognition Frameworks

CoRR
The Thai One-Stage Fingerspelling (One-Stage-TFS) dataset is a comprehensive resource designed to advance research in hand gesture recognition, explicitly focusing on the recognition of Thai sign language. This dataset comprises 7,200 images capturing 15 one-stage consonant gestures performed by undergraduate students from Rajabhat Maha Sarakham ...
Siriwiwat Lata, Sirawan Phiphiphatphaisit, Emmanuel Okafor, Olarik Surinta   +3 more
openaire   +2 more sources