Results 71 to 80 of about 22,402,763 (286)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Meta-analysis using individual participant data: one-stage and two-stage approaches, and why they may differ. [PDF]

, 2016
Meta-analysis using individual participant data (IPD) obtains and synthesises the raw, participant-level data from a set of relevant studies. The IPD approach is becoming an increasingly popular tool as an alternative to traditional aggregate data meta ...

core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Human Rights and One Parents Families: An Introduction to Human Rights and how they can used to Advance the Rights of One Parent Families in Ireland

, 2006
This booklet is an introduction to key international human rights conventions that have been ratified by the Irish Government. It aims to provide easy to understand information on how such conventions can best be used to advance the rights of one-parent ...
One Family
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The one-stage design for nationwide studies on temperature and health

Environmental Research: Health
Nationwide studies investigating the short-term health effects of ambient temperature commonly use a two-stage design that estimates location-specific associations before combining them through a meta-analysis.
Aurelio Tobias, Carmen Iñiguez
doaj   +1 more source

What Is the Role of Local Antimicrobial Protection for One-Stage Revision for Peri-Prosthetic Hip Infection?

Antibiotics
The aim of this review is to investigate the effective role of local antimicrobial protection for one-stage cemented and cementless hip revision surgery.
Carlo Luca Romanò, Luigi Bonomo, Giulio Bonomo, German Viale, Hernán Del Sel, Mohammad Tezval   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Laparoscopic one-stage (intraoperative-cholangiopancreatography / laparoscopic cholecystectomy or laparoscopic common bile duct exploration / laparoscopic cholecystectomy) vs. two-stage (pre-op cholangiopancreatography → laparoscopic cholecystectomy) for choledocholithiasis: a systematic review and meta-analysis

BMC Surgery
Background Given the limitations of previous meta-analyses and the rapid global expansion of advanced laparoscopic technology, there is a clear need for an updated systematic review focusing on recent evidence.
Behnam Reza Makhsosi, Pourya Ghobadi, Hadi Shariati, Omid Mehrazin, Amir Tarighinia   +4 more
doaj   +1 more source