Results 81 to 90 of about 16,677,913 (308)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Tek Sağlık yaklaşımının kökeni: Dünyada ve Türkiye'deki mevcut durumu: Tek Sağlık yaklaşımının kökeni

, 2023
: The One Health approach has a history of hundreds of years of thought and social development. In essence, it is a holistic understanding of health that deals with the problems that arise at the intersection of humans, animals and the environment.
Serpen, Adnan
core   +1 more source

Laparoscopic one-stage (intraoperative-cholangiopancreatography / laparoscopic cholecystectomy or laparoscopic common bile duct exploration / laparoscopic cholecystectomy) vs. two-stage (pre-op cholangiopancreatography → laparoscopic cholecystectomy) for choledocholithiasis: a systematic review and meta-analysis

BMC Surgery
Background Given the limitations of previous meta-analyses and the rapid global expansion of advanced laparoscopic technology, there is a clear need for an updated systematic review focusing on recent evidence.
Behnam Reza Makhsosi, Pourya Ghobadi, Hadi Shariati, Omid Mehrazin, Amir Tarighinia   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

New one-stage multiple comparison procedures with the average for exponential location parameters under heteroscedasticity

, 2017
In this paper, we present new one-stage multiple comparison procedures with the average for location parameters of two-parameter exponential distributions under heteroscedasticity by modifying the existing one proposed by Wu [One stage multiple ...
Wu, Shu-Fei
core   +1 more source

Occurrence and surgical repair of third degree perineal lacerations in adult female camels (Camelus dromedarius) by one-stage (Goetz) technique [PDF]

Open Veterinary Journal, 2013
Retrospective analysis of third degree perineal lacerations in 7 female camels (6-17 yrs of age) that were surgically corrected by one stage repair (Goetz technique) is presented.
S. Anwar, G.N. Purohit
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

One-stage vs. two-stage brachio-basilic arteriovenous fistula for dialysis access: a systematic review and a meta-analysis.

, 2015
IntroductionA brachiobasilic arteriovenous fistula (BB-AVF) can provide access for haemodialysis in patients who are not eligible for a more superficial fistula.
Walsh Stewart R., Donagh A. Healy (12579400), Elsheikh, Sawsan, Stewart R Walsh, Eamon G. Kavanagh (12579352), Sawsan Elsheikh (699520), Walsh, Michael T., Burke, Paul E., Walsh Michael T., Walsh, Stewart R., Browne Leonard D., Khalid Bashar, Clarke-Moloney, Mary, Paul E. Burke (12579406), Mary Clarke-Moloney (645953), Mary Clarke-Moloney, Eamon G. Kavanagh (613992), Kavanagh Eamon G., Burke Paul E., LEONARD BROWNE (12350299), Bashar Khalid, Donagh A Healy, Eamon G Kavanagh, MICHAEL WALSH (12351295), Browne, Leonard D., Khalid Bashar (613985), Michael T Walsh, Michael T. Walsh (613989), Paul E Burke, Bashar, Khalid, Leonard D. Browne (613987), Healy Donagh A., Stewart R. Walsh (10101987), Stewart R. Walsh (699521), Healy, Donagh A., Donagh A. Healy (699519), Kavanagh, Eamon G., Sawsan Elsheikh, Elsheikh Sawsan, Clarke-Moloney Mary, Leonard D Browne, Paul E. Burke (613991)   +41 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source