Results 91 to 100 of about 1,198,194 (286)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2003 DIFFERENTIATION AND INTEGRATION OF FUNCTIONS OF ONE VARIABLE, WITH APPLICATIONS. CONCEPTS OF FUNCTION, LIMITS, AND CONTINUITY. DIFFERENTIATION RULES, APPLICATION TO GRAPHING, RATES, APPROXIMATIONS, AND EXTREMUM PROBLEMS.
Starr, Jason M.
core
Algebraic semantics for one-variable lattice-valued logics
, 2022 The one-variable fragment of any first-order logic may be considered as a modal logic, where the universal and existential quantifiers are replaced by a box and diamond modality, respectively.
Metcalfe, George +2 more
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
The variable order fractional calculus of variations
, 2018 This book intends to deepen the study of the fractional calculus, giving special emphasis to variable-order ...
Tavares, Dina +3 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
"Applications of the Asymptotic Expansion Approach based on Malliavin-Watanabe Calculus in Financial Problems" [PDF]
This paper reviews the asymptotic expansion approach based on Malliavin-Watanabe Calculus in Mathematical Finance. We give the basic formulation of the asymptotic expansion approach and discuss its power and usefulness to solve important problems arised ...
Naoto Kunitomo, Akihiko Takahashi
core
, 2010 The paper discusses the problem of classical and fractional diffusion models. It is known that the classical model fails in heterogeneous structures with locations where particles move at a large speed over a long distance.
Tomas Kisela
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source