Results 111 to 120 of about 3,404,096 (265)

One cell test para el estudio in vitro de citotoxicidad del extracto de una planta de la flora colombiana

Revista Colombiana de Biotecnología, 2004
Este estudio se realizó con el fin de evaluar la toxicidad del extracto de Abuta grandifolia mediante la técnica de One cell test. El extracto etanólico se preparó mediante secado y pulverización del tallo de la A. grandifolia; la extracción se realizó con etanol al 96% y posterior­mente se hizo una extracción ácido-base hasta obtener la fracción ...
Saúl, Daniel, Mrad de Osorio, Afife, Martínez, Constanza, Cardozo de Martínez, Carmen Alicia   +3 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

ICAM1high Neutrophils Sculpt Tumor Evolution and Metastasis Through Symbiotic Adhesion and Reverse Migration. [PDF]

Cancer Res
Wu L, Xu Z, Wang J, Liu F, Ding Y, Gao Y, Wang S, Liu J, Chan HL, Wu W, Wu YH, Yu L, Hao X, Li X, Edwards DG, Sha C, Lee TD, Guan N, Aguirre S, Becerra-Dominguez L, Hoffman D, Chen X, Rivas CH, Yan XG, Bado IL, Zhang W, Zhu Q, Sreekumar A, Satcher RL, Zhang XH.   +29 more
europepmc   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Fibroblast depletion reveals mammalian epithelial resilience across neonatal and adult stages. [PDF]

J Cell Biol
Gaeta IM, Du S, Villeneuve C, Gonzalez DG, Matte-Martone C, Ganesan S, Simpson D, Tibebu H, Moore JL, Kam CY, Gallini S, Wei H, Bertillot F, Zeuschner D, Gonzalez LE, Rana U, Sumigray KD, Wickström SA, Greco V.   +18 more
europepmc   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Targeting NFATc1-regulated MTHFD2 one-carbon metabolism to suppress sustained T-cell-mediated inflammation in rheumatoid arthritis. [PDF]

Signal Transduct Target Ther
Manolakou T, Shen J, Boddul S, Samiotaki M, Panagias MA, Sentis G, Silva TA, Argyriou A, Nikolopoulos D, Sanjiv K, Chemin K, Wermeling F, Henriksson M, Slipicevic A, Jakobsson PJ, Chatzidionysiou K, Helleday T.   +16 more
europepmc   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An immunogenomic classification of solid tumours reveals subtype-specific therapeutic vulnerabilities for immunotherapy. [PDF]

EBioMedicine
Zhao Y, Wang P, Han Z, Qiu Z, Du X, Wen Q, Zhou Z, Lin X, Zhong J, Han B, Fu W, Sun K, Yao H, Na Z, Wang C, Luo T, Su D, Zeng J, Hu H, Luo ML.   +19 more
europepmc   +1 more source

Early‐Phase Research in Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley   +1 more source