Results 121 to 130 of about 5,819,085 (300)
Journal of Advanced ResearchIntroduction: As one of the common psychiatric diseases, depression poses serious threats to human health. Although many genes have been nominated for depression, few of them were investigated in details at the molecular level. Objectives: To demonstrate
Haijun Han +4 more
doaj +1 more source
Deep reconditioning of batteries during DSCS 3 flight operations [PDF]
Deep reconditioning of batteries is defined as discharge below the 1.0 volt/cell level to a value of about 1.0 volt/battery. This type of reconditioning was investigated for use on the Defense Satellite Communications System (DSCS) spacecraft, and has ...
Jones, P. W. +2 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Accelerated degradation of silicon metallization systems [PDF]
Clemson University has been engaged for the past five years in a program to determine the reliability attributes of solar cells by means of accelerated test procedures.
Lathrop, J. W.
core +1 more source
Multipartite viruses: A decentralized mode of functioning. [O.24] [PDF]
, 2015 Multipartite viruses are characterized by a genome composed of two or more nucleic acid segments, each encapsidated indivually. A classical view in virology assumes that the viral replication cycle occurs within individual cells, where the whole viral ...
Blanc, Stéphane +4 more
core
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Export of miRNAs from activated macrophages is cooperative and HuR‐dependent
FEBS Letters, EarlyView.This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh +2 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Statistical Tests Based on Empty Cells
, 2012 In professional literature on statistics, a constantly growing interest is observed in non-parametric methods. Commonly these methods are based on counting, rank or position statistics and on a number or length of series. In this paper, the least popular tests, namely tests based on a number of empty cells, are presented.
openaire +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source