Results 161 to 170 of about 29,312,700 (253)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Artery tertiary lymphoid organs encode a pathogenic high-affinity autoantibody-autoantigen pair in atherosclerosis. [PDF]

Nat Cardiovasc Res
Zhang C, Zhang X, Ran Y, Wang Z, Li L, Wang S, Zheng J, Zhang Y, Sun T, Li Y, Lu S, Hong M, Ma Z, Steffens S, Hristov M, Blanchet X, Zhu J, Dou X, Deng X, Dornmair K, Hu D, Lahiri S, Imhof A, Sachs N, Maegdefessel L, Xiao J, Zhang J, Wang Y, Hong H, Habenicht L, Weng X, Ge J, Weber C, Santovito D, Bashford-Rogers R, Mohanta SK, Ley K, Habenicht AJR, Yin C.   +38 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

4-Hydroxytamoxifen induces a noncanonical ferroptosis in lung adenocarcinoma by targeting AKR1B10. [PDF]

Clin Transl Med
Yang H, Wang Y, Jin J, Xu H, Miao Y, Wu X, Chen S, Han T, Zhan Q.   +8 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mast cell-derived IL-13 as a driver of Crohn disease-associated intestinal fibrosis. [PDF]

Inflamm Bowel Dis
Safari K, Ma WJ, Sekhon P, Rai P, Menzies SC, Hoshino T, Fratzscher AS, Roth A, Madsen K, Sly LM.   +9 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Performance of PRAME Immunohistochemistry in Distinguishing Classic Hodgkin Lymphoma from Anaplastic Large Cell Lymphoma and T-Cell Lymphoma. [PDF]

Cancers (Basel)
Duan X, Williams KN, Chen AL.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Breast cancer prevention by prophylactic Lalba mRNA-LNP vaccination. [PDF]

Proc Natl Acad Sci U S A
Nishida J, Seehawer M, Rojas Jimenez E, Yan P, Bui TM, Foidart P, Muramatsu H, Goyette MA, Cai X, Li Z, Beattie MB, Pardi N, Polyak K.   +12 more
europepmc   +1 more source