Results 181 to 190 of about 3,404,096 (265)

LPAR4 mediates resistance to interferon-induced stress in soft tissue sarcoma. [PDF]

Sci Adv
Xiao JF, Ko EY, Smith A, Piras R, Fowler A, Ishaya K, Wang L, Wang B, Paulucci-Holthauzen A, Landers SM, Bhalla AD, Torres KE, Shamsutdinova D, Wani KM, Lazar AJ, Keung EZ, Somaiah N, Nassif Haddad EF, Guarnerio J.   +18 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Extracellular flux analyses indicate low ATP yield and require refinement for accurate determination of maximal oxygen consumption rate. [PDF]

Sci Rep
Ransy C, Boissan M, Hammad N, Bouaboud A, Issad T, De Dieuleveult M, Miotto B, Ye M, Pasmant E, Bouillaud F.   +9 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

RBM15/IGF2BP2-PTPRH m6A regulatory axis in non-small cell lung cancer. [PDF]

Cell Oncol (Dordr)
Qiu K, Zheng X, Li H, Zhang J, Xie Z, Chen H, Hu Z, Sun Y, Chen Z, Tong J, Mu Y, Yao Y, Chen W, Xu G.   +13 more
europepmc   +1 more source

P706: Challenges in molecular test interpretation in patients with prior gene therapy for beta-thalassemia and sickle cell disease: One laboratory's experience

Genetics in Medicine Open
Sara Brown, Benjamin Clyde, Kelsey Cone, Patti Krautscheid, Hunter Best, Makenzie Fulmer, Archana Agarwal   +6 more
openaire   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source