Results 191 to 200 of about 29,312,700 (253)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

MLHNet-Lung: an attention-guided multi-level CNN-transformer fusion framework with CBAM and GeM pooling for explainable multiclass lung CT image classification. [PDF]

Front Med (Lausanne)
Hanif F, Ahmed AET, Raza A.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Crosstalk Between CTSB⁺ Glioblastoma Cells and S100A10⁺ Macrophages: A Self-Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy. [PDF]

Adv Sci (Weinh)
Zhang H, Zhang N, Liang X, Wen J, Dai Z, Wu W, Li S, Feng S, Liu Z, Xia Z, Luo P, Cheng Q.   +11 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Lactate-associated H3K18la upregulates RNF166 to promote immune evasion in hepatocellular carcinoma by remodeling c-Jun ubiquitination. [PDF]

Apoptosis
Ren B, Yang Y, Sheng K, Mu Q, Bai Z, Tian M, Ren Y, Lv Y, Liu K.   +8 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

International Forum on the Prevention of ABO Incompatible Red Blood Cell Transfusion: Responses. [PDF]

Vox Sang
Mirrione-Savin A, Murphy MF, Schäfer R, Tiberghien P, Arora S, Dua S, Mueller MM, Tonn T, Diop S, Seck M, Alarimi ZAF, Badawi MA, Sato T, Miyajima A, Wendel S, Fachini R, Petraszko T, Mack J, Cuppari I, Prati D, Nuñez MA, Saa E, Cohn CS, Engel BS, Wood E, Daly J, Ji Y, Zhao Y, Delettre FA, Bourcier V, Pons V, Espasa A, van der Merwe W, Wessels PL, Owusu-Ofori S, John-Teye D, Narayan S, Swarbrick N, Al-Riyami AZ, Dunbar N.   +39 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Spatially guided in vivo single-cell functional genomics of postnatal heart. [PDF]

Nat Cardiovasc Res
Wang H, Dong Y, Song Y, Colon M, Grosso C, Yapundich N, Ricketts S, Liu X, Farber G, Liu SL, Qian Y, Qian L, Liu J.   +12 more
europepmc   +1 more source