Results 201 to 210 of about 5,883,816 (326)

RNA helicase SKIV2L impedes tumor immunity by reprogramming arginine metabolism of hepatocellular carcinomas. [PDF]

J Immunother Cancer
Zhu L, Wu M, Feng B, Zhang Y, Xu Y, Yu L.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The MAFG-AS1/G6PD axis reduces platinum sensitivity in colorectal cancer through pentose phosphate pathway activation. [PDF]

J Transl Med
Kou JH, Yao Y, Li WJ, Zou J, Kong L, Zheng J, Yue YM, Han MM, Guo ST.   +8 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Molecular Engineering of the Helminth TGF-β Mimetics, TGM1 and TGM4, Reveals a Novel Antagonist of TGF-β Signaling in Fibroblasts. [PDF]

FASEB J
Cunningham KT, Ciancia C, Campion T, van Dinther M, Davis N, Duffy A, Heawood ALL, Power L, Sanders A, Singh SP, Smyth DJ, Thompson E, White R, Hinck AP, Ten Dijke P, Maizels RM.   +15 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A next-generation probiotic strain for gut health: Bacteroides cellulosilyticus LYH2 variant with anti-inflammatory and metabolic advantages. [PDF]

EBioMedicine
Lan C, Deng X, Jin S, Li H, Liu Y, Wu A, Liu Y, Zhang Y, He J, Dai Z, Chen D, Yu B, Huang Z, Mao X, Zheng P, Yu J, Luo J, Yan H, Luo Y.   +18 more
europepmc   +1 more source

Incorporating the 40-Gene Expression Profile (40-GEP) Test within Each Clinicopathologic Staging System Improves Metastatic Risk-Stratification in Patients Diagnosed with Cutaneous Squamous Cell Carcinoma (cSCC) and One or More High Risk Factors

Ashley Wysong, Ally‐Khan Somani, Sherrif F. Ibrahim, Javier Cañueto, Alison L. Fitzgerald, Jennifer J. Siegel, Anesh Prasai, Matthew S. Goldberg, Aaron S. Farberg, Julia Kasprzak, David G. Brodland, Shlomo A. Koyfman, Sarah T. Arron   +12 more
openalex   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

mRNA vaccines engage unconventional pathways in CD8⁺ T cell priming. [PDF]

Nature
Jo S, Li L, Thakur C, Telfer KA, Sultan H, Ohara RA, He M, Nam G, Chen J, Ou F, Draghi M, Valiante NM, Schreiber RD, Randolph GJ, Saligrama N, Murphy TL, Gillanders WE, Murphy KM.   +17 more
europepmc   +1 more source