Results 221 to 230 of about 29,312,700 (253)

Metformin potentiates arsenic disulfide in diffuse large B-cell lymphoma: modulation of BAX/BCL-2 apoptotic pathway and hedgehog pathway. [PDF]

Front Oncol
Zhang J, Li H, Zhao M, Chen C, Du S, Wang L.   +5 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Neoadjuvant chemoimmunotherapy with afatinib for locally advanced head and neck squamous cell carcinoma (neoCHANCE-2): an open-label, single-arm, phase 2 study. [PDF]

J Immunother Cancer
Wei Z, Chen H, Wang D, Li L, Pei Y, Yang H, Wang F, Jin J, Luo Y, Chen F, Liu J, Peng X.   +11 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Total blood volume and red blood cell volume are not associated with orthostatic intolerance in adults with myalgic encephalomyelitis/chronic fatigue syndrome. [PDF]

Physiol Rep
Yamazaki T, Mancini DM, Blate M, Quan P, Norweg A, Cook DB, Natelson BH.   +6 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Preclinical evaluation of JQ1 in esophageal squamous cell carcinoma: growth and migration suppression with BRD4-associated DNA damage and apoptotic signaling. [PDF]

Front Pharmacol
Pu C, Liu J, Fan H, Hu H, Chen T, Tang J.   +5 more
europepmc   +1 more source

Loss of CD44 re-educates pancreatic cancer-associated fibroblasts modulating their fibrotic and immunosuppressive functions. [PDF]

Cell Death Dis
Treffert SM, Heneka YM, Martin J, Gargano A, Launhardt L, Akilli Ö, Stanganello E, Andrieux G, Hoch D, Sonnentag SJ, Mehner LM, Munoz-Sagredo L, Christ M, Orian-Rousseau V.   +13 more
europepmc   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O-GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis. [PDF]

Adv Sci (Weinh)
Liu X, Luo X, Zhao J, Jiang Z, Zhai J, Zhu T, Jia X, Ma X, Jiang H, Li H, Feng Y, Ke J, Long X.   +12 more
europepmc   +1 more source

Immune niche composed of C1Q⁺ macrophages/SFRP2⁺ CAFs/CD8⁺ T cells drives immunotherapy response in HER2-positive gastric cancer. [PDF]

Nat Commun
Liao Y, Chen X, Chen H, Xie L, Zhi Y, Xu H, Zhuo X, Hu S, Zhao L, Lin C, Li Y, Zhao L.   +11 more
europepmc   +1 more source