Results 51 to 60 of about 3,404,096 (265)

Phenotypic Antibiotic Susceptibility Testing at the limit of one bacterial cell

open access: yes
The blood of a patient with bacteremia contains only a few bacteria per milliliter. Recently, techniques have been developed for extracting these few bacteria from whole blood. Here, we evaluate if a phenotypic Antibiotic Susceptibility Test (AST) can be performed on a single bacterial cell by monitoring changes in its phenotypic distributions sampled ...
Lisa Johansson   +6 more
openaire   +1 more source

Synthesis of Substituted Thieno[2,3‐d]pyrimidin‐4‐ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models

open access: yesJournal of Chemistry, 2012
From 2‐amino‐3‐ethoxycarbonyl‐4,5‐dimethyl‐, ‐polymethylenethiophenes (1-4) were synthesized 2,3‐disubstituted thieno[2,3‐d]dihydropyrrolo‐, tetrahydropyrido‐, and tetrahydroazepino[1,2‐a]pyrimidin‐4‐ones (5-16) for pharmacological investigations. The 12 compounds (5-16) were individually evaluated for their antiproliferative activities on mammalian ...
Kh. A. Bozorov   +7 more
openaire   +3 more sources

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge   +6 more
wiley   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte   +5 more
wiley   +1 more source

Effect of ozone oil and non-surgical periodontal treatment in patients with type 2 diabetes. In-vivo and in-vitro studies with fibroblasts and Candida albicans [PDF]

open access: yesJournal of Applied Oral Science
Aim To evaluate the clinical effectiveness of ozonated sunflower oil (Oz) as an adjunctive of non-surgical periodontal therapy in patients with type 2 diabetes mellitus (DM2), on fibroblast cell viability and migration and the effectiveness of Oz on a ...
Raquel Alves do CARMO   +9 more
doaj   +1 more source

Serological profiling of rabies antibodies by enzyme-linked immunosorbent assay and its comparative analysis with rapid fluorescent focus inhibition test in mouse model [PDF]

open access: yesVeterinary World, 2019
Aim: In this study, we have used enzyme-linked immunosorbent assay (ELISA) as an alternative test to replace the cumbersome rapid fluorescent focus inhibition test (RFFIT) to ascertain the immune status of immunized mice against rabies virus ...
Ashis Debnath   +9 more
doaj   +1 more source

Ironic Medications: A Narrative‐Based Psycho‐Educational Intervention to Explore Patient–Provider Communication in Adolescents With Haematological Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with haematological malignancies face significant emotional and relational challenges, often accompanied by difficulties in communicating their needs within the healthcare context. To address these issues, a narrative‐based psycho‐educational intervention based on the creation and prescription of Ironic Medications was ...
Marta Stoppa   +7 more
wiley   +1 more source

Escherichia coli cell bank: development, characterization, and transfer for biopharmaceutical medicines production (review)

open access: yesРазработка и регистрация лекарственных средств
Introduction. Biological medicines produced using recombinant DNA technology play an important role in the international pharmaceutical market. Currently, bacterial and mammalian expression systems are widely used to produce recombinant proteins ...
E. A. Buslaeva   +5 more
doaj   +1 more source

Incidence and Severity of Carboplatin‐Associated Hearing Loss in Children With Cancer Assessed by the SIOP Boston 2012 Ototoxicity Criteria

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Platinum‐based chemotherapy is known to cause severe and debilitating hearing loss, but unlike cisplatin, the true incidence of carboplatin‐induced hearing loss remains unclear. We evaluated functional hearing outcomes in children receiving carboplatin to determine the incidence and severity of ototoxicity. Procedure We identified a
Aniket Chawla   +6 more
wiley   +1 more source

Comparison between immunohistochemical expression of Ki-67 and MCM-3 in major salivary gland epithelial tumors in children and adolescents. Preliminary study

open access: yesPolish Journal of Pathology, 2017
While Ki-67 expression is frequently used as an indicator of tumor cell proliferation, alternative markers have also been proposed. Possible alternative indicators of proliferation are the minichromosome maintenance (MCM) proteins, whose levels are ...
Rafał Zieliński   +2 more
doaj   +1 more source

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