Results 81 to 90 of about 35,039,938 (235)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Impact of tumor-associated macrophages (TAM) in tumor hypoxia and aerobic glycolysis

, 2019
1
AHN, G ONE
core  

Comparison of isoelectronic 8-HO-G and 8-NH2-G derivatives in redox processes

, 2009
8-Oxo-7,8-dihydroguanine (8-oxo-G) is the major lesion of oxidatively generated DNA damage. Despite two decades of intense study, several fundamental properties remain to be defined.
Spadafora M, Chatgilialoglu C, Gimisis T, Guerra M, Mulazzani Q G, Kaloudis P, Cismas C, D'Angelantonio M   +7 more
core   +1 more source

Study of rotavirus genotypes G and P in one Egyptian center-cross-sectional study

Italian Journal of Pediatrics
Background Rotavirus-associated gastroenteritis is a common health problem in children, different variations of rotavirus genotypes differ according to geographic locations and the practice of wide-scale vaccination. Therefore, the present study aimed to
AbelRahman Eid Mahmoud, Maysaa El Sayed Zaki, Eman Hamdy Mohamed, Ehab M. Fahmy, Sanaa Samir Mohamed Hamam, Mona Abdellatif Alsayed   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A novel role of tumor-associated macrophages (TAM) in modulating tumor metabolism

, 2018
2
AHN, G ONE
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Role of tumor-associated macrophages (TAM) in modulating the tumor metabolism

, 2018
2
AHN, G ONE
core  

Evolution of the Limpopo River Basin in Botswana based on morphometric and morphotectonic features from selected rivers using GIS techniques

Geology, Ecology, and Landscapes
This study used morphometric techniques to generate new information describing the evolution and hydrogeological behaviour of the Limpopo River Basin in Botswana, based on the analysis of drainage surface features, form, and size. Drainage basins provide
One Moses, Read B Mapeo, Joyce G Maphanyane   +2 more
doaj   +1 more source