Results 161 to 170 of about 181,190 (235)

Kaempferol Attenuates Myocardial Ischemia–Reperfusion Injury by Suppressing Ferroptosis via the KEAP1–Nrf2–GPX4 Axis

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao   +6 more
wiley   +1 more source

Olaparib Blocks Oxidative Stress‐Dependent NLRP3 Inflammasome in Pediatric Acute Lung Injury by Metabolic Reprogramming via AMPK‐Driven Autophagic Flux

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pediatric acute lung injury (ALI) is a life‐threatening syndrome defined by dysregulated pulmonary inflammation and impaired alveolar gas exchange, with limited therapeutic interventions. This study aims to evaluate the therapeutic efficacy and mechanistic basis of Olaparib, a clinically approved PARP inhibitor, using in vitro and in vivo ...
Fen Gong   +5 more
wiley   +1 more source

Trends in the Asthma Burden Attributable to High Body Mass Index in Children Across 204 Countries and Territories, 1990–2021: An Analysis of the 2021 Global Burden of Disease Study

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT High body mass index (BMI) has been identified as a significant risk factor for childhood asthma. Given the rising prevalence of childhood obesity, assessing the impact of high BMI on asthma burden trends is imperative. Utilizing Global Burden of Disease (GBD) data, we estimated age‐, sex‐, geography‐, and sociodemographic index (SDI ...
Hua Li   +4 more
wiley   +1 more source

Characterizing Post Tonsillectomy Respiratory Complications in Patients Under Three

open access: yesThe Laryngoscope, EarlyView.
ABSTRACT Objective To characterize the postoperative respiratory complications in children < 3 years old who underwent tonsillectomy. Methods Retrospective chart review of patients < 3 years old at time of tonsillectomy. Demographics, comorbidities, polysomnography results, intraoperative factors, and postoperative respiratory complications ...
Nathan E. Lu   +4 more
wiley   +1 more source

Differences in the Evaluation and Diagnosis of Obstructive Sleep Apnea by Sex: A Systematic Review

open access: yesThe Laryngoscope, EarlyView.
This systematic review of 33 studies found that females with obstructive sleep apnea generally presented at an older age and with higher BMI, whereas males generally had greater neck circumference and apnea‐hypopnea index. These findings highlight clinically relevant sex‐based differences in OSA evaluation and support more individualized approaches to ...
Alexandra Vacaru   +6 more
wiley   +1 more source

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